Patents by Inventor Rene Beerli

Rene Beerli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CARBOXAMIDE INHIBITORS
    Publication number: 20170088546
    Abstract: The present invention provides a compound of formula I The compounds of formula I demonstrate properties as Smurf-1 inhibitors and are thus useful in the treatment of a range of disorders, particularly pulmonary arterial hypertension.
    Type: Application
    Filed: May 14, 2015
    Publication date: March 30, 2017
    Applicant: NOVARTIS AG
    Inventors: Luca ARISTA, Rene BEERLI, Simona COTESTA, Pier Luca D'ALESSANDRO, Rene LATTMANN, Robert Alexander PULZ, Thomas J. TROXLER
  • Aryl-quinazoline/aryl-2amino-phenyl methanone derivatives
    Patent number: 8569317
    Abstract: A compound of formula (1): wherein R1, R2, R3 and Y are as defined herein, or a pharmaceutically-acceptable and -cleavable ester, or acid addition salt thereof, useful for promoting the release of parathyroid hormone, e.g. for preventing or treating bone conditions which are associated with increased calcium depletion or resorption or in which stimulation of bone formation and calcium fixation in the bone is desirable.
    Type: Grant
    Filed: October 15, 2009
    Date of Patent: October 29, 2013
    Assignee: Novartis AG
    Inventors: Eva Altmann, Rene Beerli, Marc Gerspacher, Johanne Renaud, Sven Weiler, Leo Widler
  • Quinazoline derivatives which promote the release of parathyroid hormone
    Patent number: 8476286
    Abstract: Use of compound of formula (I), wherein, is, or, and wherein the symbols are as defined, or a pharmaceutically-acceptable and -cleavable ester, or acid addition salt thereof, for the preparation of a medicament for promoting the release of parathyroid hormone, e.g. for preventing or treating bone conditions which are associated with increased calcium depletion or resorption or in which stimulation of bone formation and calcium fixation in the bone is desirable.
    Type: Grant
    Filed: June 14, 2002
    Date of Patent: July 2, 2013
    Assignee: Novartis AG
    Inventors: René Beerli, Ruben A Tommasi, Sven Weiler, Leo Widler
  • BENZOQUINAZOLINE DERIVATIVES
    Publication number: 20100166765
    Abstract: A compound of formula (I) or a pharmaceutically acceptable salt or prodrug ester thereof, wherein the groups R2, R3, R4, Q, X and Y are as defined in the specification, is useful in the treatment of bone conditions related to increased calcium depletion or resorption.
    Type: Application
    Filed: August 14, 2006
    Publication date: July 1, 2010
    Inventors: Sandra Ammon, Rene Beerli, Leo Widler
  • Aryl-quinazoline/aryl-2-amino-phenyl methanone derivatives
    Patent number: 7696216
    Abstract: A compound of formula (I): wherein R1, R2, R3 and Y are as defined herein, or a pharmaceutically-acceptable and -cleavable ester, or acid addition salt thereof, useful for promoting the release of parathyroid hormone, e.g. for preventing or treating bone conditions which are associated with increased calcium depletion or resorption or in which stimulation of bone formation and calcium fixation in the bone is desirable.
    Type: Grant
    Filed: December 22, 2003
    Date of Patent: April 13, 2010
    Assignee: Novartis AG
    Inventors: Eva Altmann, Rene Beerli, Marc Gerspacher, Johanne Renaud, Sven Weiler, Leo Widler
  • Aryl-quinazoline/aryl-2amino-phenyl methanone derivatives
    Publication number: 20100063075
    Abstract: A compound of formula (1): wherein R1, R2, R3 and Y are as defined herein, or a pharmaceutically-acceptable and -cleavable ester, or acid addition salt thereof, useful for promoting the release of parathyroid hormone, e.g. for preventing or treating bone conditions which are associated with increased calcium depletion or resorption or in which stimulation of bone formation and calcium fixation in the bone is desirable.
    Type: Application
    Filed: October 15, 2009
    Publication date: March 11, 2010
    Inventors: Eva Altmann, Rene Beerli, Marc Gerspacher, Johanne Renaud, Sven Weiler, Leo Widler
  • Phenylisoquinoline and Phenylquinazoline Derivatives
    Publication number: 20090074791
    Abstract: The present invention relates to substituted phenylisoquinoline and phenylquinazoline derivatives and to their pharmaceutical uses in preventing or treating bone conditions which are associated with increased calcium depletion or resorption or in which stimulation of bone formation and calcium fixation in the bone is desirable.
    Type: Application
    Filed: September 2, 2008
    Publication date: March 19, 2009
    Inventor: Rene Beerli
  • Organic Compounds
    Publication number: 20090069360
    Abstract: The present invention relates to the discovery that certain compounds inhibit, regulate and/or modulate tyrosine and serine/threonine kinase and kinase-like proteins, such as RAF kinase, a serine/threonine kinase that functions in the MAP kinase signaling pathway, and is concerned with compositions which contain these compounds, and methods of using them to treat tyrosine and serine/threonine kinase and kinase-like dependent diseases, such as angiogenesis, cancer and cardiac hypertrophy.
    Type: Application
    Filed: March 14, 2007
    Publication date: March 12, 2009
    Inventors: David Bryant Batt, Rene Beerli, Guido Bold, Giorgio Caravatti, Timothy Michael Ramsey
  • Aryl-quinazoline/aryl-2amino-phenyl methanone derivatives
    Publication number: 20060079685
    Abstract: A compound of formula (I): wherein R1, R2, R3 and Y are as defined herein, or a pharmaceutically-acceptable and -cleavable ester, or acid addition salt thereof, useful for promoting the release of parathyroid hormone, e.g. for preventing or treating bone conditions which are associated with increased calcium depletion or resorption or in which stimulation of bone formation and calcium fixation in the bone is desirable.
    Type: Application
    Filed: December 22, 2003
    Publication date: April 13, 2006
    Inventors: Eva Altmann, Rene Beerli, Marc Gerspacher, Johanne Renaud, Sven Weiler, Leo Widler
  • Crystal structure of the ligand binding domain of the retinoic acid-related orphan receptor alpha (ror-alpha)
    Publication number: 20050165218
    Abstract: The present invention relates RORa in crystallized form and methods for the preparation thereof. The invention also provides a three-dimensional model of RORa and means for the design of RORa modulators. Ligands binding to RORa are also provided.
    Type: Application
    Filed: April 28, 2003
    Publication date: July 28, 2005
    Inventors: Rene Beerli, Brigitte Fournier, Jorg Kallen, Jean-Marc Schlaeppi
  • Quinazoline derivatives
    Publication number: 20040180912
    Abstract: Use of compound of formula (I), wherein, is, or, and wherein the symbols are as defined, or a pharmaceutically-acceptable and-cleavable ester, or acid addition salt thereof, for the preparation of a medicament for promoting the release of parathyroid hormone, e.g. for preventing or treating bone conditions which are associated with increased calcium depletion or resorption or in which stimulation of bone formation and calcium fixation in the bone is desirable.
    Type: Application
    Filed: December 12, 2003
    Publication date: September 16, 2004
    Inventors: Rene Beerli, Ruben Alberto Tommasi, Sven Weiler, Leo Widler
  • Covalently immobilized fluoroionophores for optical ion sensors
    Patent number: 6294390
    Abstract: Compounds, constructed in modular manner, of formula (I), wherein I is the monovalent residue of an ionophore, F is the monovalent residue of a fluorophore, G is a functional group, T is a trivalent organic radical and R01, R02 and R03 are each independently of the others a direct bond or a bridging group. The compounds may be used in immobilized form as active components in polymer membranes of optical sensors for the detection of ions. The sensors are distinguished by a long usable life and a high degree of sensitivity.
    Type: Grant
    Filed: January 21, 1999
    Date of Patent: September 25, 2001
    Assignee: Novartis Ag
    Inventors: Steven Mark Barnard, René Beerli, Joseph Berger, David Reinhoudt, Adrian Waldner
  • Sensors
    Patent number: 6245574
    Abstract: Sensors for the qualitative and quantitative determination of K+ ions in aqueous systems are described, which consist essentially of a carrier and an active layer applied to this carrier, whereby the active layer contains a polymer in which is dispersed at least one modified valinomycin, in which a radical of a fluorescence dye which emits in long waves, preferably an acridine or fluorescein, with an emission wave length of >550, is covalently bound.
    Type: Grant
    Filed: June 30, 1998
    Date of Patent: June 12, 2001
    Assignee: Novartis AG
    Inventors: Adrian Waldner, René Beerli, Steven Mark Barnard