Abstract: The present invention relates to an aqueous solution for organ preservation, in particular for the myocardium, the solution comprising: 100 mM to 130 mM of Na+; 12 mM to 15 mM of K+; 0.25 mM to 1.3 mM of Ca++; 0.5 ?M to 1.5 ?M of cyclosporin A; and 0.5 ?M to 1.5 ?M of taxol, and it also relates to the joint use of cyclosporin A and taxol in a solution for in vitro preservation of an organ, in particular the myocardium.

Abstract: The present invention relates to an aqueous solution for organ preservation, in particular for the myocardium, the solution comprising: 100 mM to 130 mM of Na+; 12 mM to 15 mM of K+; 0.25 mM to 1.3 mM of Ca++; 0.5 ?M to 1.5 ?M of cyclosporin A; and 0.5 ?M to 1.5 ?M of taxol, and it also relates to the joint use of cyclosporin A and taxol in a solution for in vitro preservation of an organ, in particular the myocardium.

Abstract: A device for hypothermic perfusion of a cardiac organ comprising a first sealed tank able to contain a physiological liquid, a second sealed tank communicating, in a sealed manner, with an internal volume of the first tank via a nozzle, a device for refrigerating the first tank and keeping the first tank at a substantially constant temperature and a device for intermittently pressurizing the internal volume of the first tank. The first tank communicates with the pressurizing device by way of a conduit connecting an interior of the first tank to the pressurizing device to permit pressurization of the internal volume of the first tank, and of the physiological liquid inside the first tank, in order to perform perfusion of the organ. The second tank comprises a safety element formed by an overflow outlet duct which communicates with the first tank and includes a non-return valve.

Abstract: The present invention relates to a method and device for the hypothermic perfusion of a cardiac organ. According to the invention, the infusion device comprises: a. a first sealed tank (2) that is capable of containing a physiological liquid (LP); b. a second sealed tank (3) that is in communication, in a sealed manner, with the inner space of the first tank by means of a nozzle (6); c. a means for refrigerating the first tank (2) and keeping it at a substantially constant temperature; and d. a means (4) for intermittently pressurizing the inner space of the first tank.