Patents by Inventor Rene Gantier

Rene Gantier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protease resistant modified erythropoietin polypeptides
    Patent number: 8114839
    Abstract: Modified erythropoietin polypeptides that include the mutation R131Q, and uses thereof are provided. Also provided are pharmaceutical compositions, including compositions formulated for oral administration, that contain the modified erythropoietin polypeptides and uses of the compositions to treat diseases and conditions treated by erythropoietin.
    Type: Grant
    Filed: June 6, 2008
    Date of Patent: February 14, 2012
    Assignee: HanAll BioPharma Co., Ltd.
    Inventors: Rene Gantier, Manuel Vega, Lila Drittanti, Thierry Guyon
  • Protease resistant modified IFN beta polypeptides and their use in treating diseases
    Patent number: 8105573
    Abstract: Protease resistant modified interferon-beta polypeptides, and pharmaceutical compositions containing such modified interferon-beta polypeptides are provided. The modified interferon-beta polypeptides contain amino acid substitutions that confer increased resistance to proteolysis over unmodified IFN beta cytokine molecules. The present invention provides for pharmaceutical formulations suitable for oral, nasal and pulmonary administration, and the use of such formulations in the treatment of disease.
    Type: Grant
    Filed: January 26, 2011
    Date of Patent: January 31, 2012
    Assignee: Hanall Biopharma Co., Ltd.
    Inventors: Rene Gantier, Manuel Vega, Lila Drittanti, Thierry Guyon
  • Protease resistant modified interferon-beta polypeptides
    Patent number: 8057787
    Abstract: Protease resistant modified interferon-beta polypeptides, pharmaceutical compositions and methods of treatment administering the compositions are provided. The modified interferon-beta polypeptides are orally available; hence pharmaceutical compositions formulated for oral administration also are provided.
    Type: Grant
    Filed: April 9, 2008
    Date of Patent: November 15, 2011
    Assignee: Hanall Biopharma Co., Ltd.
    Inventors: Rene Gantier, Manuel Vega, Lila Drittanti, Thierry Guyon
  • Interferon-? mutants with increased anti-proliferative activity
    Patent number: 8052964
    Abstract: Protease resistant modified interferon-beta polypeptides, pharmaceutical compositions and methods of treatment by administering the compositions are provided. The modified interferon-beta polypeptides are orally available; hence pharmaceutical compositions formulated for oral administration also are provided.
    Type: Grant
    Filed: April 9, 2008
    Date of Patent: November 8, 2011
    Assignee: Hanall Biopharma Co., Ltd.
    Inventors: Rene Gantier, Manuel Vega, Lila Drittanti, Thierry Guyon
  • Protease resistant interferon beta mutants
    Patent number: 7998469
    Abstract: Compositions of modified cytokines and uses thereof generated using processes and systems for the high throughput directed evolution of peptides and proteins, particularly cytokines that act in complex biological settings, are provided. Also provided are modified cytokines formulated for oral delivery and uses thereof to treat diseases and conditions mediated by cytokines.
    Type: Grant
    Filed: February 13, 2007
    Date of Patent: August 16, 2011
    Assignee: Hanall Biopharma Co., Ltd.
    Inventors: Rene Gantier, Manuel Vega, Lila Drittanti, Thierry Guyon
  • PROTEASE RESISTANT MODIFIED INTERFERON-BETA POLYPEPTIDES AND THEIR USE IN TREATING DISEASES
    Publication number: 20110142801
    Abstract: Protease resistant modified interferon-beta polypeptides, pharmaceutical compositions and methods of treatment by administering the compositions are provided. The modified interferon-beta polypeptides are orally available; hence pharmaceutical compositions formulated for oral administration also are provided.
    Type: Application
    Filed: January 26, 2011
    Publication date: June 16, 2011
    Applicant: HANALL BIOPHARMA CO., LTD.
    Inventors: Rene GANTIER, Manuel VEGA, Lila DRITTANTI, Thierry GUYON
  • Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
    Patent number: 7650243
    Abstract: Compositions of modified cytokines and uses thereof generated using processes and systems for the high throughput directed evolution of peptides and proteins, particularly cytokines that act in complex biological settings, are provided. Also provided are modified cytokines formulated for oral delivery and uses thereof to treat diseases and conditions mediated by cytokines.
    Type: Grant
    Filed: February 14, 2007
    Date of Patent: January 19, 2010
    Assignee: Hanall Pharmaceutical Co., Ltd.
    Inventors: Rene Gantier, Manuel Vega, Lila Drittanti, Thierry Guyon
  • Protease resistant modified interferon alpha polypeptides
    Patent number: 7611700
    Abstract: Processes and systems for the high throughput directed evolution of peptides and proteins, particularly cytokines that act in complex biological settings, are provided. Also provided is a rational method for generating protein variants and the resulting variants.
    Type: Grant
    Filed: September 8, 2003
    Date of Patent: November 3, 2009
    Assignee: Hanall Pharmaceuticals, Co., Ltd.
    Inventors: Rene Gantier, Manuel Vega, Lila Drittanti, Thierry Guyon
  • Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
    Publication number: 20090131318
    Abstract: Compositions of modified cytokines and uses thereof generated using processes and systems for the high throughput directed evolution of peptides and proteins, particularly cytokines that act in complex biological settings, are provided. Also provided are modified cytokines formulated for oral delivery and uses thereof to treat diseases and conditions mediated by cytokines.
    Type: Application
    Filed: June 6, 2008
    Publication date: May 21, 2009
    Inventors: Rene Gantier, Manuel Vega, Lila Drittanti, Thierry Guyon
  • Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
    Publication number: 20090123974
    Abstract: Compositions of modified cytokines and uses thereof generated using processes and systems for the high throughput directed evolution of peptides and proteins, particularly cytokines that act in complex biological settings, are provided. Also provided are modified cytokines formulated for oral delivery and uses thereof to treat diseases and conditions mediated by cytokines.
    Type: Application
    Filed: April 9, 2008
    Publication date: May 14, 2009
    Inventors: Rene Gantier, Manuel Vega, Lila Drittanti, Thierry Guyon
  • Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
    Publication number: 20090053147
    Abstract: Compositions of modified cytokines and uses thereof generated using processes and systems for the high throughput directed evolution of peptides and proteins, particularly cytokines that act in complex biological settings, are provided. Also provided are modified cytokines formulated for oral delivery and uses thereof to treat diseases and conditions mediated by cytokines.
    Type: Application
    Filed: April 9, 2008
    Publication date: February 26, 2009
    Inventors: Rene Gantier, Manuel Vega, Lila Drittanti, Thierry Guyon
  • Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
    Publication number: 20080274081
    Abstract: Compositions of modified cytokines and uses thereof generated using processes and systems for the high throughput directed evolution of peptides and proteins, particularly cytokines that act in complex biological settings, are provided. Also provided are modified cytokines formulated for oral delivery and uses thereof to treat diseases and conditions mediated by cytokines.
    Type: Application
    Filed: February 13, 2007
    Publication date: November 6, 2008
    Inventors: Rene Gantier, Manuel Vega, Lila Drittanti, Thierry Guyon
  • Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
    Publication number: 20080194477
    Abstract: Compositions of modified cytokines and uses thereof generated using processes and systems for the high throughput directed evolution of peptides and proteins, particularly cytokines that act in complex biological settings, are provided. Also provided are modified cytokines formulated for oral delivery and uses thereof to treat diseases and conditions mediated by cytokines.
    Type: Application
    Filed: February 7, 2007
    Publication date: August 14, 2008
    Inventors: Rene Gantier, Manuel Vega, Lila Drittanti, Thierry Guyon
  • Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
    Publication number: 20080159977
    Abstract: Compositions of modified cytokines and uses thereof generated using processes and systems for the high throughput directed evolution of peptides and proteins, particularly cytokines that act in complex biological settings, are provided. Also provided are modified cytokines formulated for oral delivery and uses thereof to treat diseases and conditions mediated by cytokines.
    Type: Application
    Filed: July 5, 2007
    Publication date: July 3, 2008
    Inventors: Rene Gantier, Manuel Vega, Lila Drittanti, Thierry Guyon
  • Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
    Publication number: 20080075672
    Abstract: Compositions of modified cytokines and uses thereof generated using processes and systems for the high throughput directed evolution of peptides and proteins, particularly cytokines that act in complex biological settings, are provided. Also provided are modified cytokines formulated for oral delivery and uses thereof to treat diseases and conditions mediated by cytokines.
    Type: Application
    Filed: February 6, 2007
    Publication date: March 27, 2008
    Inventors: Rene Gantier, Manuel Vega, Lila Drittanti, Thierry Guyon
  • Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
    Publication number: 20070254838
    Abstract: Compositions of modified cytokines and uses thereof generated using processes and systems for the high throughput directed evolution of peptides and proteins, particularly cytokines that act in complex biological settings, are provided. Also provided are modified cytokines formulated for oral delivery and uses thereof to treat diseases and conditions mediated by cytokines.
    Type: Application
    Filed: January 22, 2007
    Publication date: November 1, 2007
    Inventors: Rene Gantier, Manuel Vega, Lila Drittanti, Thierry Guyon
  • Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
    Publication number: 20070224665
    Abstract: Compositions of modified cytokines and uses thereof generated using processes and systems for the high throughput directed evolution of peptides and proteins, particularly cytokines that act in complex biological settings, are provided. Also provided are modified cytokines formulated for oral delivery and uses thereof to treat diseases and conditions mediated by cytokines.
    Type: Application
    Filed: February 14, 2007
    Publication date: September 27, 2007
    Inventors: Rene Gantier, Manuel Vega, Lila Drittanti, Thierry Guyon
  • Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
    Publication number: 20070172459
    Abstract: Compositions of modified cytokines and uses thereof generated using processes and systems for the high throughput directed evolution of peptides and proteins, particularly cytokines that act in complex biological settings, are provided. Also provided are modified cytokines formulated for oral delivery and uses thereof to treat diseases and conditions mediated by cytokines.
    Type: Application
    Filed: February 13, 2007
    Publication date: July 26, 2007
    Inventors: Rene Gantier, Manuel Vega, Lila Drittanti, Thierry Guyon
  • Rational directed protein evolution using two-dimensional rational mutagenesis scanning
    Publication number: 20060020396
    Abstract: Rational methods for generating protein variants are provided. Processes and systems for the high throughput directed evolution of peptides and proteins employing the method are provided.
    Type: Application
    Filed: August 2, 2005
    Publication date: January 26, 2006
    Inventors: Rene Gantier, Thierry Guyon, Hugo Ramos, Manuel Vega, Lila Drittanti
  • Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
    Publication number: 20060020116
    Abstract: Compositions of modified cytokines and uses thereof generated using processes and systems for the high throughput directed evolution of peptides and proteins, particularly cytokines that act in complex biological settings, are provided. Also provided are modified cytokines formulated for oral delivery and uses thereof to treat diseases and conditions mediated by cytokines.
    Type: Application
    Filed: July 6, 2005
    Publication date: January 26, 2006
    Inventors: Rene Gantier, Thierry Guyon, Manuel Vega, Lila Drittanti