Patents by Inventor Rene Labatut

Rene Labatut has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hyperbaric device and methods for producing inactivated vaccines and for refolding/solubilizing recombinant proteins
    Patent number: 10080791
    Abstract: The invention relates to hyperbaric devices for inactivating microorganisms and viruses while retaining their immunogenicity and for making and producing the soluble, disaggregated, refolded or active immunogenic or therapeutic proteins from inclusion bodies produced from prokaryotes or eukaryotes. The invention encompasses hyperbaric methods for inactivating pathogenic organisms, and methods for producing vaccine compositions using the inactivated pathogens. The hyperbarically inactivated microorganisms are safer and more immunogenic than chemically inactivated microorganisms. Similarly, the solubilized proteins have superior properties compared to more heavily aggregated proteins, including reduced non-specific immune reactions.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: September 25, 2018
    Assignee: MERIAL INC.
    Inventors: Nicolas Pierre Yves Carboulec, Rene Labatut, Lionel Gerentes
  • Hyperbaric Device and Methods for Producing Inactivated Vaccines and for Refolding/Solubilizing Recombinant Proteins
    Publication number: 20160000896
    Abstract: The invention relates to hyperbaric devices for inactivating microorganisms and viruses while retaining their immunogenicity and for making and producing the soluble, disaggregated, refolded or active immunogenic or therapeutic proteins from inclusion bodies produced from prokaryotes or eukaryotes. The invention encompasses hyperbaric methods for inactivating pathogenic organisms, and methods for producing vaccine compositions using the inactivated pathogens. The hyperbarically inactivated microorganisms are safer and more immunogenic than chemically inactivated microorganisms. Similarly, the solubilized proteins have superior properties compared to more heavily aggregated proteins, including reduced non-specific immune reactions.
    Type: Application
    Filed: September 11, 2015
    Publication date: January 7, 2016
    Applicant: MERIAL INC.
    Inventors: Nicolas Pierre Yves Carboulec, Rene Labatut, Lionel Gerentes
  • Hyperbaric device and methods for producing inactivated vaccines and for refolding/solubilizing recombinant proteins
    Patent number: 9169302
    Abstract: The invention relates to hyperbaric devices for inactivating microorganisms and viruses while retaining their immunogenicity and for making and producing the soluble, disaggregated, refolded or active immunogenic or therapeutic proteins from inclusion bodies produced from prokaryotes or eukaryotes. The invention encompasses hyperbaric methods for inactivating pathogenic organisms, and methods for producing vaccine compositions using the inactivated pathogens. The hyperbarically inactivated microorganisms are safer and more immunogenic than chemically inactivated microorganisms. Similarly, the solubilized proteins have superior properties compared to more heavily aggregated proteins, including reduced non-specific immune reactions.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: October 27, 2015
    Assignees: MERIAL, INC., Top Industrie S.A.S.
    Inventors: Nicolas Pierre Yves Carboulec, Gildas Merian, Rene Labatut, Lionel Gerentes
  • Hyperbaric Device and Methods for Producing Inactivated Vaccines and for Refolding/Solubilizing Recombinant Proteins
    Publication number: 20140065187
    Abstract: The invention relates to hyperbaric devices for inactivating microorganisms and viruses while retaining their immunogenicity and for making and producing the soluble, disaggregated, refolded or active immunogenic or therapeutic proteins from inclusion bodies produced from prokaryotes or eukaryotes. The invention encompasses hyperbaric methods for inactivating pathogenic organisms, and methods for producing vaccine compositions using the inactivated pathogens. The hyperbarically inactivated microorganisms are safer and more immunogenic than chemically inactivated microorganisms. Similarly, the solubilized proteins have superior properties compared to more heavily aggregated proteins, including reduced non-specific immune reactions.
    Type: Application
    Filed: August 30, 2013
    Publication date: March 6, 2014
    Applicants: TOP INDUSTRIE S.A.S., MERIAL LIMITED
    Inventors: Nicolas Pierre Yves Carboulec, Gildas Merian, Rene Labatut, Lionel Gerentes
  • Method for removing unconventional transmissible agents from a protein solution
    Patent number: 6372510
    Abstract: The present invention is drawn to method for removing unconventional transmissible agents (UCTA) from aqueous protein solution. This method involves treating the aqueous protein solution with simultaneous electrostatic adsorption and hydrophobic chromatography. The method of the present invention is particularly suitable for treating calf serum or an albumin solution.
    Type: Grant
    Filed: November 10, 1998
    Date of Patent: April 16, 2002
    Assignee: Pasteur Merieux Serum et Vaccins
    Inventors: Michel Grandgeorge, René Labatut, Jean-Marc Rouzioux, Jean-Louis Tayot, Jean-Luc Veron