Patents by Inventor Rene P. Traber

Rene P. Traber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cyclosporins
    Patent number: 5981479
    Abstract: It has been found that nonimmunosuppressive, cyclophilin-binding cyclosporins are useful in the treatment and prevention of AIDS and AIDS-related disorders. Such cyclosporins include novel Ciclosporin derivatives modified at the 4- and/or 5-positions.
    Type: Grant
    Filed: May 26, 1998
    Date of Patent: November 9, 1999
    Assignee: Novartis AG
    Inventors: Soo Young Ko, Hans Kobel, Brigitte Besemer-Rosenwirth, Dieter Seebach, Rene P. Traber, Roland Wenger, Pietro Bollinger
  • Cyclosporins
    Patent number: 5767069
    Abstract: Nonimmunosuppressant cyclosporin derivatives having cyclophilin-binding activity, for example, the compound, ?MeIle!.sup.4 -ciclosporin, are useful in inhibiting HIV-1 replication in treating AIDS and AIDS related disorders.
    Type: Grant
    Filed: April 24, 1995
    Date of Patent: June 16, 1998
    Assignee: Novartis AG
    Inventors: Soo Young Ko, Hans Kobel, Brigitte Besemer-Rosenwirth, Dieter Seebach, Rene P. Traber, Roland Wenger, Pietro Bollinger
  • Novel cyclosporins
    Patent number: 4639434
    Abstract: Cyclosporins wherein the amino acid residue at the 8-position is a (D)-acyloxy-.alpha.-amino acid residue, typically of formula ##STR1## wherein X=-MeBmt- or -dihydro-MeBmt-, Y=-.alpha.Abu-, -Ala-, -Thr-, -Val- or -Nva-, Z=-Val- or -Nva- and Q=R.sub.1 --CO--O--CH(R.sub.2)--CH(CO--)--NH--wherein R.sub.1 =H, C.sub.1-4 alkyl or phenyl and R.sub.2 =H or CH.sub.3, possess immunosuppressive, anti-inflammatory and anti-parasitic activity.
    Type: Grant
    Filed: March 19, 1985
    Date of Patent: January 27, 1987
    Assignee: Sandoz Ltd.
    Inventors: Roland Wenger, Rene P. Traber, Hans Kobel, Hans Hofmann
  • Process for producing cyclosporin derivatives
    Patent number: 4289851
    Abstract: The present invention relates to cyclosporin derivatives, especially compounds of formula I ##STR1## wherein A is ##STR2## useful as anti-arthritic agents.
    Type: Grant
    Filed: March 3, 1980
    Date of Patent: September 15, 1981
    Assignee: Sandoz Ltd.
    Inventors: Rene P. Traber, Max Kuhn, Hans Hofmann, Eugen Harri
  • Cyclosporin derivatives, their production and pharmaceutical compositions containing them
    Patent number: 4288431
    Abstract: Compounds of formula I ##STR1## selected from the group consisting of cyclosporin G, wherein A is ##STR2## dihydrocyclosporin G, wherein A is ##STR3## and isocyclosporin G, wherein A is ##STR4## are useful in treating inflammations and arthritis and as immuno-suppressant agents.
    Type: Grant
    Filed: October 12, 1979
    Date of Patent: September 8, 1981
    Assignee: Sandoz Ltd.
    Inventors: Rene P. Traber, Hans Hofmann, Eugen Harri, Kuhn Max
  • Organic compounds
    Patent number: 4220641
    Abstract: The present invention relates to cyclosporin derivatives, especially compounds of formula I ##STR1## wherein A is ##STR2## useful as anti-arthritic agents.
    Type: Grant
    Filed: May 4, 1978
    Date of Patent: September 2, 1980
    Assignee: Sandoz Ltd.
    Inventors: Rene P. Traber, Max Kuhn, Hans Hofmann, Eugen Harri