Patents by Inventor Rene Rahimoff
Rene Rahimoff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250236631Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D, G12V, G12A, G12S, G13D, Q61H, Q61L or G12C. The compounds have a general Formula I?: wherein the variables of Formula I? are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.Type: ApplicationFiled: April 11, 2025Publication date: July 24, 2025Applicant: AMGEN INC.Inventors: Ryan Paul Wurz, Yunxiao LI, Primali Vasundera NAVARATNE, Jose M. MEDINA, Ning CHEN, Liping PETTUS, Xiaofen LI, John STELLWAGEN, Kexue LI, Brian Alan LANMAN, Michael M. YAMANO, Wei ZHAO, Benjamin WIGMAN, Fabien EMMETIERE, Albert K. AMEGADZIE, Christopher P. MOHR, Aaron C. SIEGMUND, Rene RAHIMOFF, Zhichen WU, Adriano BAUER, Andrew SMALIGO, Quentin Tercenio, Qingyian Liu, Shon K. Booker, Jeffrey Jackson
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Publication number: 20250179077Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D, G12V, G12A, G12S or G12C. The compounds have a general Formula (I): (Formula (I)) wherein the variables of Formula (I) are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.Type: ApplicationFiled: February 15, 2023Publication date: June 5, 2025Applicant: AMGEN INC.Inventors: Brian Alan Lanman, Ryan Paul Wurz, Wei Zhao, Xiaofen LI, Imelda HOT, Rene RAHIMOFF, Liping Pettus, Ning Chen, Fabien EMMETIERE, Jeffery Jackson, Yunxiao LI, Francesco Manoni, Primali Navaratne, Andrew Smaligo, John Charles Stellwagen, John Allen
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Publication number: 20250163064Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D, G12V, G12A, G12S or G12C. The compounds have a general Formula I: (I) wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.Type: ApplicationFiled: February 15, 2023Publication date: May 22, 2025Applicant: AMGEN INC.Inventors: Brian Alan Lanman, Ryan Paul Wurz, Wei Zhao, Xiaofen LI, Michael YAMANO, Imelda HOT, Rene RAHIMOFF, Liping Pettus, Jose Medina
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Publication number: 20250122222Abstract: The present disclosure provides compounds useful for the inhibition of KRAS. The compounds have a general Formula I: wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.Type: ApplicationFiled: August 10, 2022Publication date: April 17, 2025Applicant: AMGEN INC.Inventors: Michael M. YAMANO, Yunxiao LI, Primali Vasundera NAVARATNE, Jose M. MEDINA, Ning CHEN, Liping PETTUS, Rene RAHIMOFF, Xiaofen LI, John STELLWAGEN, Francesco MANONI, Kexue LI, Brian Alan LANMAN, Ryan Paul Wurz, Wei ZHAO, Huan RUI, Josephine ESHON
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Publication number: 20250059205Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D. The compounds have a general Formula I: (I) wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.Type: ApplicationFiled: April 28, 2022Publication date: February 20, 2025Applicant: AMGEN INC.Inventors: Brian Alan Lanman, Ryan Paul Wurz, Wei Zhao, Xiaofen Li, Michael M. Yamano, Yunxiao Li, Ning Chen, Birgitte Weinreich Husemoen, Sebastian Leth-Petersen, Jose M. Medina, Kexue Li, Liping Pettus, Rene Rahimoff, Primali Vasundera Navaratne, Huan Rui, Christopher P. Mohr
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Publication number: 20250059179Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D. The compounds have a general Formula I: (I) wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.Type: ApplicationFiled: April 28, 2022Publication date: February 20, 2025Applicant: AMGEN INC.Inventors: Brian Alan Lanman, Ryan Paul Wurz, Wei Zhao, Xiaofen Li, Michael M. Yamano, Yunxiao Li, Ning Chen, Sebastian Leth-Petersen, Kexue Li, Liping Pettus, Rene Rahimoff, Primali Vasundera Navaratne, Huan Rui
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Publication number: 20250034167Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D. The compounds have a general Formula (I): wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.Type: ApplicationFiled: August 10, 2022Publication date: January 30, 2025Applicant: AMGEN INC.Inventors: Michael M. YAMANO, Yunxiao LI, Primali Vasundera NAVARATNE, Jose M. MEDINA, Ning CHEN, Liping PETTUS, Rene RAHIMOFF, Xiaofen LI, John STELLWAGEN, Francesco MANONI, Kexue LI, Brian Alan LANMAN, Ryan Paul Wurz, Wei ZHAO, Huan RUI, Josephine ESHON
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Publication number: 20240417412Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D. The compounds have a general Formula I: wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.Type: ApplicationFiled: August 10, 2022Publication date: December 19, 2024Applicant: AMGEN INC.Inventors: Brian Alan Lanman, Wei Zhao, Ryan Paul Wurz, Primali Vasundera NAVARATNE, Liping PETTUS, Michael M. YAMANO, Ning Chen, Rene RAHIMOFF, Francesco MANONI, John STELLWAGEN
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Publication number: 20240294551Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D, G12V, G12A, G12S, G13D, Q61H, Q61L or G12C. The compounds have a general Formula I?: wherein the variables of Formula I? are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.Type: ApplicationFiled: March 25, 2024Publication date: September 5, 2024Applicant: AMGEN INC.Inventors: Ryan Paul Wurz, Yunxiao LI, Primali Vasundera NAVARATNE, Jose M. MEDINA, Ning CHEN, Liping PETTUS, Xiaofen LI, John STELLWAGEN, Kexue LI, Brian Alan LANMAN, Michael M. YAMANO, Wei ZHAO, Benjamin WIGMAN, Fabien EMMETIERE, Albert K. AMEGADZIE, Christopher P. MOHR, Aaron C. SIEGMUND, Rene RAHIMOFF, Zhichen WU, Adriano BAUER, Andrew SMALIGO, Quentin Tercenio, Qingyian Liu, Shon K. Booker
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Publication number: 20240124442Abstract: Described herein are novel PRMT5 inhibitors of Formula I and pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders.Type: ApplicationFiled: February 3, 2022Publication date: April 18, 2024Applicant: AMGEN INC.Inventors: Albert AMEGADZIE, Diane Jennifer BEYLKIN, Shon BOOKER, Matthew Paul BOURBEAU, John R. BUTLER, Kevin Lloyd GREENMAN, Todd J. KOHN, Kexue LI, Qingyian LIU, Ana Elena MINATTI, Primali Vasundera NAVARATNE, Liping H. PETTUS, Rene RAHIMOFF, Hui-Ling WANG, Nicholas Anthony WEIRES
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Publication number: 20240101570Abstract: Described herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, such as cancer, metabolic and blood disorders. Compounds of Formula (I) have the following structure of Formula (I).Type: ApplicationFiled: November 22, 2021Publication date: March 28, 2024Inventors: Albert AMEGADZIE, Diane Jennifer BEYLKIN, Shon BOOKER, Matthew Paul BOURBEAU, John R. BUTLER, Sanne Ormholt Schroder GLAD, Todd J. KOHN, Brian Alan LANMAN, Kexue LI, Qingyian LIU, Patricia LOPEZ, Francesco MANONI, Primali Vasundera NAVARATNE, Liping H. PETTUS, Rene RAHIMOFF, Nuria A. TAMAYO, Mikkel VESTERGAARD, Hui-Ling WANG, Nicholas Anthony WEIRES
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Patent number: 11442046Abstract: The present invention relates to reagents suitable in the mass spectrometric determination of analyte molecules such as carbohydrates as well as adducts of such reagents and analyte molecules and applications of said reagents and adducts. Further, the present invention relates to methods for the mass spectrometric determination of analyte molecules.Type: GrantFiled: July 24, 2019Date of Patent: September 13, 2022Assignee: Roche Diagnostics Operations, Inc.Inventors: Thomas Carell, Uwe Kobold, Dieter Heindl, Silvia Baecher, Andreas Leinenbach, Martin Rempt, Toni Pfaffeneder, Angie Kirchner, Olesea Kosmatchev, Rene Rahimoff, Sarah Schiffers, Markus Muller
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Publication number: 20200041470Abstract: The present invention relates to reagents suitable in the mass spectrometric determination of analyte molecules such as carbohydrates as well as adducts of such reagents and analyte molecules and applications of said reagents and adducts. Further, the present invention relates to methods for the mass spectrometric determination of analyte molecules.Type: ApplicationFiled: July 24, 2019Publication date: February 6, 2020Inventors: Thomas Carell, Uwe Kobold, Dieter Heindl, Silvia Baecher, Andreas Leinenbach, Martin Rempt, Toni Pfaffeneder, Angie Kirchner, Olesea Kosmatchev, Rene Rahimoff, Sarah Schiffers, Markus Muller
