Abstract: A method for planning and carrying out clinical studies, wherein, during and after the end of a predetermined period, values of a predefined target criterion of control persons of a virtual control group are compared with values of the predefined target criterion of test persons of a test group which received a treatment to be investigated. The values of the predefined target criterion of the control persons of the virtual control group during and after the end of the predetermined period are determined from starting characteristics values assigned to the control persons.

Abstract: Spiro-(N'-methyl-piperidyl-4')-N-ethyl-succinimide for the treatment of Alzheimer's disease and senile dementia of the Alzheimer type.

Abstract: Method of treating sleep disturbance which comprises administering a compound of formula ##STR1## wherein R.sub.1 is phenethyl or butyrophenone optionally mono-substituted in the phenyl ring by fluorine, chlorine, bromine or lower alkyl or alkoxy, R.sub.2 is OR.sub.5 wherein R.sub.5 is lower alkyl or alkenyl or phenyl optionally mono-substituted by fluorine, chlorine, bromine, or alkoxy; or N(R.sub.6)R.sub.7 wherein R.sub.6 and R.sub.7 are each hydrogen, lower alkyl or cycloalkylalkyl, cycloalkyl, phenyl optionally mono-substituted by fluorine, chlorine, bromine, lower alkyl or lower alkoxy or lower phenylalkyl optionally mono-substituted in the phenyl ring by fluorine, chlorine, bromine or lower alkyl or alkoxy or R.sub.6 and R.sub.7 together with the nitrogen atom to which they are bound form a saturated heterocycle of 5 to 6 ring members, and either R.sub.3 is lower alkyl or cycloalkylalkyl, cycloalkyl or phenyl optionally mono-substituted by fluorine, chlorine, bromine or lower alkyl or alkoxy or, when R.

Abstract: The present invention concerns a novel therapeutic use as a sleep-promoting agent for the known pharmaceutical compound 10-[2-(1-methyl-2-piperidyl)ethyl]-2-methylsulphinylphenothiazine of the formula: ##STR1##