Patents by Inventor Rene Wyler

Rene Wyler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Piperazine amide derivatives
    Patent number: 8288541
    Abstract: The invention is concerned with novel piperazine amide derivatives of formula (I) wherein R1 to R11, W, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds bind to LXR alpha and LXR beta and can be used as medicaments.
    Type: Grant
    Filed: August 6, 2008
    Date of Patent: October 16, 2012
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Henrietta Dehmlow, Bernd Kuhn, Ulrike Obst Sander, Stephan Roever, Tanja Schulz-Gasch, Matthew Wright, Rene Wyler
  • PIPERAZINE AMIDE DERIVATIVES
    Publication number: 20090048264
    Abstract: The invention is concerned with novel piperazine amide derivatives of formula (I) wherein R1 to R11, W, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds bind to LXR alpha and LXR beta and can be used as medicaments.
    Type: Application
    Filed: August 6, 2008
    Publication date: February 19, 2009
    Inventors: Henrietta Dehmlow, Bernd Kuhn, Ulrike Obst Sander, Stephan Roever, Tanja Schulz-Gasch, Matthew Wright, Rene Wyler
  • Benzyloxy derivatives
    Patent number: 7456210
    Abstract: The present invention relates to compounds of formula I wherein R1 and R2 are as defined in the specification and to pharmaceutically acceptable salts thereof for the treatment of diseases, which are mediated by monoamine oxidase B inhibitors, for example Alzheimer's disease and senile dementia.
    Type: Grant
    Filed: July 27, 2005
    Date of Patent: November 25, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Rosa Maria Rodriguez-Sarmiento, Wolfgang Wostl, Rene Wyler
  • Benzyloxy derivatives as MAOB inhibitors
    Patent number: 7253318
    Abstract: The invention relates to compounds of the formula and their pharmaceutically acceptable salts wherein R1, R2, R3, R4, R5, n, m, and o are as defined in the specification. The compounds are selective monoamine oxidase ? inhibitors and are useful for the treatment and prevention of Alzheimer's disease and senile dementia, as well as other CNS disorders. The invention also relates to processes for preparing such compounds and pharmaceutical compositions containing them.
    Type: Grant
    Filed: June 20, 2005
    Date of Patent: August 7, 2007
    Assignee: Hoffman-La Roche Inc.
    Inventors: Synese Jolidon, Rosa Maria Rodriguez-Sarmiento, Andrew William Thomas, Wolfgang Wostl, Rene Wyler
  • 4-pyrrolidino-phenyl-benzyl ether derivatives
    Patent number: 7235581
    Abstract: The invention relates to racemic or enantiomerically pure 4-pyrrolidino derivatives, processes for their preparation, pharmaceutical compositions comprising said derivatives, and their use in the prevention and treatment of illness, e.g. which are mediated by monoamine oxidase B inhibitors, in particular Alzheimer's disease or senile dementia.
    Type: Grant
    Filed: September 18, 2003
    Date of Patent: June 26, 2007
    Assignee: Hoffman-La Roche Inc.
    Inventors: Synese Jolidon, Rosa Maria Rodriguez-Sarmiento, Andrew William Thomas, Wolfgang Wostl, Rene Wyler
  • Bicyclic compounds
    Publication number: 20070117791
    Abstract: The present invention relates to methods for making and using novel benzazepine derivatives of the following formula: wherein R1, R2, R3, R4 and R5, X, X?, Y and Y? are as defined in the description and claims, processes for their preparation, pharmaceutical compositions containing said derivatives and their use for the preparation of medicaments useful for the prevention and treatment of diseases in which selective inhibition of monoamine oxidase B activity plays a role or is implicated.
    Type: Application
    Filed: January 12, 2007
    Publication date: May 24, 2007
    Inventors: Synese Jolidon, Rosa Rodriguez Sarmiento, Andrew Thomas, Wolfgang Wostl, Rene Wyler
  • Bicyclic compounds
    Patent number: 7173023
    Abstract: The present invention relates to novel benzazepine derivatives of the following formula: wherein R1, R2, R3, R4 and R5, X, X?, Y and Y? are as defined in the description and claims, processes for their preparation, pharmaceutical compositions containing said derivatives and their use for the preparation of medicaments useful for the prevention and treatment of diseases in which selective inhibition of monoamine oxidase B activity plays a role or is implicated.
    Type: Grant
    Filed: October 18, 2004
    Date of Patent: February 6, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Synese Jolidon, Rosa Maria Rodriguez Sarmiento, Andrew William Thomas, Wolfgang Wostl, Rene Wyler
  • 4-pyrrolidino-phenyl-benzyl ether derivatives
    Patent number: 7151111
    Abstract: The invention relates to racemic or enantiomerically pure 4-pyrrolidino derivatives, processes for their preparation, pharmaceutical compositions comprising said derivatives, and their use in the prevention and treatment of a disease which is mediated by a monoamine oxidase B inhibitor, in particular Alzheimer's disease and senile dementia.
    Type: Grant
    Filed: September 18, 2003
    Date of Patent: December 19, 2006
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Hans Iding, Synese Jolidon, Daniela Krummenacher, Rosa Maria Rodriguez-Sarmiento, Andrew William Thomas, Beat Wirz, Wolfgang Wostl, Rene Wyler
  • 4-pyrrolidino-phenyl-benzyl ether derivatives
    Patent number: 7122562
    Abstract: The invention relates to racemic or enantiomerically pure 4-pyrrolidino derivatives, processes for their preparation, pharmaceutical compositions comprising said derivatives, and their use in the prevention and treatment of illness, in particular which is mediated by monoamine oxidase B inhibitors, in particular Alzheimer's disease or senile dementia.
    Type: Grant
    Filed: January 5, 2006
    Date of Patent: October 17, 2006
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Hans Iding, Synese Jolidon, Daniela Krummenacher, Rosa Maria Rodriguez-Sarmiento, Andrew William Thomas, Beat Wirz, Wolfgang Wostl, Rene Wyler
  • 3H-quinazolin-4-one derivatives as MAO-B inhibitors
    Patent number: 7087612
    Abstract: This invention relates to 3H-quinazolin-4-one derivatives as defined in the specification and claims, to a process for their preparation, to pharmaceutical compositions comprising them and to their use as selective monoamine oxidase B inhibitors.
    Type: Grant
    Filed: December 13, 2003
    Date of Patent: August 8, 2006
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Rosa Maria Rodriguez Sarmiento, Andrew William Thomas, Rene Wyler
  • 4-pyrrolidino-phenyl-benzyl ether derivatives
    Publication number: 20060122235
    Abstract: The invention relates to racemic or enantiomerically pure 4-pyrrolidino derivatives, processes for their preparation, pharmaceutical compositions comprising said derivatives, and their use in the prevention and treatment of illness, in particular which is mediated by monoamine oxidase B inhibitors, in particular Alzheimer's disease or senile dementia.
    Type: Application
    Filed: January 5, 2006
    Publication date: June 8, 2006
    Inventors: Hans Iding, Synese Jolidon, Daniela Krummenacher, Rosa Rodriguez-Sarmiento, Andrew Thomas, Beat Wirz, Wolfgang Wostl, Rene Wyler
  • N-acylamino benzyl ether derivatives
    Patent number: 7053245
    Abstract: This invention relates to N-acylamino aryl derivatives of the formula where R1, R21, R22, R23, R24, R3, R4, R5, R6, R7, R8, R, and n are as defined herein and where X is —CHRO, —OCHR—, —CH2S—, —SCH2—, —CH2CH2—, —CH?CH— or —C?C—. The compounds of the invention are selective monoamine oxidase B inhibitors, and they are therefore useful in the treatment of diseases mediated by monoamine oxidase B, for example, for the treatment of Alzheimer's disease or senile dementia.
    Type: Grant
    Filed: May 5, 2004
    Date of Patent: May 30, 2006
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Synese Jolidon, Rosa Maria Rodriguez Sarmiento, Andrew William Thomas, Rene Wyler
  • 4-Pyrrolidino-phenyl-benzyl ether derivatives
    Patent number: 7037935
    Abstract: The invention relates to racemic or enantiomerically pure 4-pyrrolidino derivatives, processes for their preparation, pharmaceutical compositions comprising said derivatives, and their use in the prevention and treatment of illness, in particular which is mediated by monoamine oxidase B inhibitors, in particular Alzheimer's disease or senile dementia.
    Type: Grant
    Filed: September 18, 2003
    Date of Patent: May 2, 2006
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Hans Iding, Synese Jolidon, Daniela Krummenacher, Rosa Maria Rodriguez-Sarmiento, Andrew William Thomas, Beat Wirz, Wolfgang Wostl, Rene Wyler
  • Conjugated aromatic compounds with a pyridine substituent
    Patent number: 7034044
    Abstract: The present invention relates to compounds of formulae The compounds of the present invention are NMDA (N-methyl-D-aspartate)-receptor subtype blockers and are used in the treatment of diseases related to this receptor.
    Type: Grant
    Filed: September 26, 2003
    Date of Patent: April 25, 2006
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Alexander Alanine, Bernd Buettelmann, Marie-Paule Heitz Neidhart, Emmanuel Pinard, Rene Wyler
  • Conjugated aromatic compounds with a pyridine substituent
    Publication number: 20060058354
    Abstract: The present invention relates to compounds of formulae The compounds of the present invention are NMDA (N-methyl-D-aspartate)-receptor subtype blockers and are used in the treatment of diseases related to this receptor.
    Type: Application
    Filed: October 21, 2005
    Publication date: March 16, 2006
    Inventors: Alexander Alanine, Bernd Buettelmann, Marie-Paule Neidhart, Emmanuel Pinard, Rene Wyler
  • Benzyloxy derivatives
    Publication number: 20060025599
    Abstract: The present invention relates to compounds of formula I wherein R1 and R2 are as defined in the specification and to pharmaceutically acceptable salts thereof for the treatment of diseases, which are mediated by monoamine oxidase B inhibitors, for example Alzheimer's disease and senile dementia.
    Type: Application
    Filed: July 27, 2005
    Publication date: February 2, 2006
    Inventors: Rosa Rodriguez-Sarmiento, Wolfgang Wostl, Rene Wyler
  • Benzyloxy derivatives as MAOB inhibitors
    Publication number: 20050288367
    Abstract: The invention relates to compounds of the formula and their pharmaceutically acceptable salts wherein R1, R2, R3, R4, R5, n, m, and o are as defined in the specification. The compounds are selective monoamine oxidase ? inhibitors and are useful for the treatment and prevention of Alzheimer's disease and senile dementia, as well as other CNS disorders. The invention also relates to processes for preparing such compounds and pharmaceutical compositions containing them.
    Type: Application
    Filed: June 20, 2005
    Publication date: December 29, 2005
    Inventors: Synese Jolidon, Rosa Rodriguez-Sarmiento, Andrew Thomas, Wolfgang Wostl, Rene Wyler
  • N-acylamino benzyl ether derivatives
    Publication number: 20050283019
    Abstract: This invention relates to N-acylamino aryl derivatives of the formula where R1R21, R22, R23, R24, R3, R4, R5, R6, R7, R8, R, and n are as defined herein and where X is —CHRO, —OCHR—, —CH2S—, —SCH2—, —CH2CH2—, —CH?CH— or —C?C—. The compounds of the invention are selective monoamine oxidase B inhibitors, and they are therefore useful in the treatment of diseases mediated by monoamine oxidase B, for example, for the treatment of Alzheimer's disease or senile dementia.
    Type: Application
    Filed: August 26, 2005
    Publication date: December 22, 2005
    Inventors: Synese Jolidon, Rosa Rodriguez Sarmiento, Andrew Thomas, Rene Wyler
  • Conjugated aromatic compounds with a pyridine substituent
    Patent number: 6951875
    Abstract: The present invention relates to compounds of formulae The compounds of the present invention are NMDA (N-methyl-D-aspartate)-receptor subtype blockers and are used in the treatment of diseases related to this receptor.
    Type: Grant
    Filed: October 21, 2002
    Date of Patent: October 4, 2005
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Alexander Alanine, Bernd Buettelmann, Marie-Paule Heitz Neidhart, Emmanuel Pinard, Rene Wyler
  • Fluorobenzamides and uses thereof
    Patent number: 6951884
    Abstract: The invention relates to fluorobenzamide derivatives of the formula wherein R1, R2, R3 R4, R5, R6 and R7 are as defined herein. =, The compounds of the invention are selective monoamine oxidase B inhibitors and therefore they are suitable for the treatment of diseases mediated by monoamine oxidase B, such as Alzheimer's disease or senile dementia.
    Type: Grant
    Filed: June 6, 2003
    Date of Patent: October 4, 2005
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Synese Jolidon, Rosa Maria Rodriguez Sarmiento, Andrew William Thomas, Rene Wyler