Patents by Inventor Renee A. Reijo-Pera

Renee A. Reijo-Pera has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mechanical biomarkers for oocyte and embryo viability
    Patent number: 10031123
    Abstract: Provided are methods for the determination of the viability of a mammalian embryo or a potential embryo generated from a mammalian oocyte, comprising applying a mechanical stimulus to the embryo or oocyte, detecting a temporal response of the embryo or oocyte to the mechanical stimulus, and deriving measurements for one or more parameters from the temporal response, the measurements being indicative of viability. Also provided are methods for selecting an embryo for transfer and methods for enhancing the viability of an embryo or oocyte.
    Type: Grant
    Filed: October 21, 2015
    Date of Patent: July 24, 2018
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Livia Zarnescu, David B. Camarillo, Jinnuo Han, Renee A. Reijo Pera, Shawn L. Chavez, Barry Behr
  • Induction of germ cells from pluripotent cells
    Patent number: 9920300
    Abstract: Methods and compositions are provided for promoting germ cell differentiation from pluripotent cells, and for identifying agents that modulate germ cell differentiation.
    Type: Grant
    Filed: October 22, 2010
    Date of Patent: March 20, 2018
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Keh Kooi Kee, Renee A. Reijo Pera
  • Methods of detecting aneuploidy in human embryos
    Patent number: 9879307
    Abstract: Methods, compositions and kits for determining the developmental potential of one or more embryos or pluripotent cells and/or the presence of chromosomal abnormalities in one or more embryos or pluripotent cells are provided. These methods, compositions and kits find use in identifying embryos and oocytes in vitro that are most useful in treating infertility in humans.
    Type: Grant
    Filed: February 23, 2012
    Date of Patent: January 30, 2018
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Shawn L. Chavez, Kevin E. Loewke, Barry Behr, Renee A. Reijo Pera
  • IMAGING AND EVALUATING EMBRYOS, OOCYTES, AND STEM CELLS
    Publication number: 20170089820
    Abstract: Methods, compositions and kits for determining the developmental potential of one or more embryos or pluripotent cells and/or the presence of chromosomal abnormalities in one or more embryos or pluripotent cells are provided. These methods, compositions and kits find use in identifying embryos and oocytes in vitro that are most useful in treating infertility in humans.
    Type: Application
    Filed: July 7, 2016
    Publication date: March 30, 2017
    Inventors: Connie C. WONG, Kevin E. LOEWKE, Thomas M. BAER, Renee A. REIJO-PERA, Barry BEHR
  • Markers for the detection of human embryo developmental quality
    Patent number: 9458506
    Abstract: Markers are provided for genetic and epigenetic diagnosis of embryos to determine those of which are more likely to be chromosomally normal and advance in development.
    Type: Grant
    Filed: October 30, 2014
    Date of Patent: October 4, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Shawn L. Chavez, Renee A. Reijo Pera, Sohyun L. McElroy, Barry Behr, Lynn M. Westphal
  • Non-invasive imaging to the blastocyst stage for the detection of human embryonic aneuploidy
    Patent number: 9404908
    Abstract: Methods are provided for the non-invasive imaging of embryos to determine whether they are euploid or aneuploid.
    Type: Grant
    Filed: April 28, 2014
    Date of Patent: August 2, 2016
    Assignee: The Board of Truestees of the Leland Stanford Junior University
    Inventors: Shawn L. Chavez, Brooke Friedman, Barry Behr, Renee A. Reijo Pera
  • GENERATION OF MALE GERM CELLS
    Publication number: 20160137975
    Abstract: Methods are provided for the generation of male germ cells from somatic cells. Included are methods of non-integrative reprogramming for germ cell differentiation with a reduced risk of neoplasia during in vivo differentiation by the inclusion of VASA with the reprogramming factors. Also included are methods of generating male germ cells from reprogrammed pluripotent cells by direct injection of the reprogrammed cells into the seminiferous tubules. In some embodiments the somatic cells are derived from a male with oligospermia or azoospermia, which may be the result of a genetic abnormality in Azoospermia Factor (AZF) region.
    Type: Application
    Filed: July 10, 2014
    Publication date: May 19, 2016
    Inventors: Cyril Yeshwant Ramathal, Jens Dumuthy-Durruthy, Renee A. Reijo Pera, Kyle E. Orwig
  • MECHANICAL BIOMARKERS FOR OOCYTE AND EMBRYO VIABILITY
    Publication number: 20160109428
    Abstract: Provided are methods for the determination of the viability of a mammalian embryo or a potential embryo generated from a mammalian oocyte, comprising applying a mechanical stimulus to the embryo or oocyte, detecting a temporal response of the embryo or oocyte to the mechanical stimulus, and deriving measurements for one or more parameters from the temporal response, the measurements being indicative of viability. Also provided are methods for selecting an embryo for transfer and methods for enhancing the viability of an embryo or oocyte.
    Type: Application
    Filed: October 21, 2015
    Publication date: April 21, 2016
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Livia Zarnescu, David B. Camarillo, Jinnuo Han, Renee A. Reijo Pera, Shawn L. Chavez, Barry Behr
  • Mechanical biomarkers for oocyte and embryo viability
    Patent number: 9179935
    Abstract: Provided are methods for the determination of the viability of a mammalian embryo or a potential embryo generated from a mammalian oocyte, comprising applying a mechanical stimulus to the embryo or oocyte, detecting a temporal response of the embryo or oocyte to the mechanical stimulus, and deriving measurements for one or more parameters from the temporal response, the measurements being indicative of viability. Also provided are methods for selecting an embryo for transfer and methods for enhancing the viability of an embryo or oocyte.
    Type: Grant
    Filed: January 11, 2013
    Date of Patent: November 10, 2015
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Livia Zarnescu, David B. Camarillo, Jinnuo Han, Renee A. Reijo Pera, Shawn L. Chavez, Barry Behr
  • MARKERS FOR THE DETECTION OF HUMAN EMBRYO DEVELOPMENTAL QUALITY
    Publication number: 20150119282
    Abstract: Markers are provided for genetic and epigenetic diagnosis of embryos to determine those of which are more likely to be chromosomally normal and advance in development.
    Type: Application
    Filed: October 30, 2014
    Publication date: April 30, 2015
    Inventors: Shawn L. Chavez, Renee A. Reijo Pera, Sohyun L. McElroy, Barry Behr, Lynn M. Westphal
  • Imaging and evaluating embryos, oocytes, and stem cells
    Patent number: 8989475
    Abstract: Methods, compositions and kits for determining the developmental potential of one or more embryos or pluripotent cells and/or the presence of chromosomal abnormalities in one or more embryos or pluripotent cells are provided. These methods, compositions and kits find use in identifying embryos and oocytes in vitro that are most useful in treating infertility in humans.
    Type: Grant
    Filed: February 1, 2013
    Date of Patent: March 24, 2015
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Connie C. Wong, Kevin E. Loewke, Thomas M. Baer, Renee A. Reijo-Pera, Barry Behr
  • Imaging and evaluating embryos, oocytes, and stem cells
    Patent number: 8951184
    Abstract: Methods, compositions and kits for determining the developmental potential of one or more embryos or pluripotent cells and/or the presence of chromosomal abnormalities in one or more embryos or pluripotent cells are provided. These methods, compositions and kits find use in identifying embryos and oocytes in vitro that are most useful in treating infertility in humans.
    Type: Grant
    Filed: February 1, 2013
    Date of Patent: February 10, 2015
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Connie C. Wong, Kevin E. Loewke, Thomas M. Baer, Renee A. Reijo-Pera, Barry Behr
  • NON-INVASIVE IMAGING TO THE BLASTOCYST STAGE FOR THE DETECTION OF HUMAN EMBRYONIC ANEUPLOIDY
    Publication number: 20140349334
    Abstract: Methods are provided for the non-invasive imaging of embryos to determine whether they are euploid or aneuploid.
    Type: Application
    Filed: April 28, 2014
    Publication date: November 27, 2014
    Inventors: Shawn L. Chavez, Brooke Friedman, Barry Behr, Renee A. Reijo Pera
  • Enhanced efficiency of induced pluripotent stem cell generation from human somatic cells
    Patent number: 8883430
    Abstract: A substantially pure population of human somatic cells that have enhanced potential to become induced pluripotent stem cells (iPS cells) is provided. Also provided are methods for generating this population of cells and methods for generating iPS cells from this population of cells.
    Type: Grant
    Filed: August 18, 2010
    Date of Patent: November 11, 2014
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Renee A. Reijo Pera, James Byrne
  • Imaging and evaluating embryos, oocytes, and stem cells
    Patent number: 8721521
    Abstract: Methods, compositions and kits for determining the developmental potential of one or more embryos or pluripotent cells and/or the presence of chromosomal abnormalities in one or more embryos or pluripotent cells are provided. These methods, compositions and kits find use in identifying embryos and oocytes in vitro that are most useful in treating infertility in humans.
    Type: Grant
    Filed: August 23, 2010
    Date of Patent: May 13, 2014
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Connie C. Wong, Kevin E. Loewke, Thomas M. Baer, Renee A. Reijo-Pera, Barry Behr
  • METHODS OF DETECTING ANEUPLOIDY IN HUMAN EMBRYOS
    Publication number: 20140087376
    Abstract: Methods, compositions and kits for determining the developmental potential of one or more embryos or pluripotent cells and/or the presence of chromosomal abnormalities in one or more embryos or pluripotent cells are provided. These methods, compositions and kits find use in identifying embryos and oocytes in vitro that are most useful in treating infertility in humans.
    Type: Application
    Filed: February 23, 2012
    Publication date: March 27, 2014
    Applicant: The Board Of Trustees of the Leland Stanford Junior University
    Inventors: Shawn L. Chavez, Kevin E. Loewke, Barry Behr, Renee A. Reijo Pera
  • Human multipotent germ line stem cells expressing a germ line marker and a pluripotency marker produced by co-culture of testicular tissue
    Patent number: 8673637
    Abstract: A method of in vitro maturation of adult human germ line cells in an artificial biological environment, which entails: a) isolating human spermatogonial stem cells (SSCs), and optionally purifying the same; and b) co-culturing the isolated and optionally purified SSCs with a suitably adjusted Sertoli cell environment to obtain haploid germ cells.
    Type: Grant
    Filed: October 16, 2009
    Date of Patent: March 18, 2014
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Renee Reijo Pera, Paul J. Turek, Juanito Meneses, Nina Kossack
  • Imaging and evaluating embryos, oocytes, and stem cells
    Patent number: 8337387
    Abstract: Methods, compositions and kits for determining the developmental potential of one or more embryos or pluripotent cells and/or the presence of chromosomal abnormalities in one or more embryos or pluripotent cells are provided. These methods, compositions and kits find use in identifying embryos and oocytes in vitro that are most useful in treating infertility in humans.
    Type: Grant
    Filed: November 22, 2011
    Date of Patent: December 25, 2012
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Connie C. Wong, Kevin E. Loewke, Thomas M. Baer, Renee A. Reijo-Pera, Barry Behr
  • Imaging and evaluating embryos, oocytes, and stem cells
    Patent number: 8323177
    Abstract: Methods, compositions and kits for determining the developmental potential of one or more embryos or pluripotent cells and/or the presence of chromosomal abnormalities in one or more embryos or pluripotent cells are provided. These methods, compositions and kits find use in identifying embryos and oocytes in vitro that are most useful in treating infertility in humans.
    Type: Grant
    Filed: November 22, 2011
    Date of Patent: December 4, 2012
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Connie C. Wong, Kevin E. Loewke, Thomas M. Baer, Renee A. Reijo-Pera, Barry Behr
  • Induction of Germ Cells from Pluripotent Cells
    Publication number: 20120231451
    Abstract: Methods and compositions are provided for promoting germ cell differentiation from pluripotent cells, and for identifying agents that modulate germ cell differentiation.
    Type: Application
    Filed: October 22, 2010
    Publication date: September 13, 2012
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Keh Kooi Kee, Renee A. Reijo Pera