Patents by Inventor Renee Brissette
Renee Brissette has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20110124556Abstract: Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, which are present on insulin and insulin-like growth factor receptors, and which selectively bind the peptides of this invention. As agonists, certain of the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonists may also be developed as therapeutics.Type: ApplicationFiled: April 20, 2010Publication date: May 26, 2011Applicants: NOVO NORDISK A/S, ANTYRA INC.Inventors: RENUKA PILLUTLA, RENEE BRISSETTE, ARTHUR J. BLUME, LAUGE SCHAFFER, JAKOB BRANDT, NEIL I. GOLDSTEIN, JANE SPETZLER, SOREN OSTERGAARD, PER HERTZ HANSEN
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Publication number: 20090192072Abstract: Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, which are present on insulin and insulin-like growth factor receptors, and which selectively bind the peptides of this invention. As agonists, certain of the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonists may also be developed as therapeutics.Type: ApplicationFiled: November 21, 2008Publication date: July 30, 2009Applicants: Novo Nordisk A/S, Antyra Inc. (formerly DGI Bio Technologies)Inventors: Renuka Pillutla, Renee Brissette, Arthur J. Blume, Lauge Schaffer, Jacob Brandt, Neil I. Goldstein, Jane Spetzler, Soren Ostergaard, Per Hertz Hansen
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Publication number: 20090053807Abstract: Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, which are present on insulin and insulin-like growth factor receptors, and which selectively bind the peptides of this invention. As agonists, the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonist peptides may also be developed as therapeutics.Type: ApplicationFiled: December 3, 2007Publication date: February 26, 2009Applicants: Novo Nordisk A/S, Antyra Inc.Inventors: Renuka Pillutla, Olga Dedova, Arthur J. Blume, Neil I. Goldstein, Renee Brissette, Pinger Wang, Hao Liu, Ku-chuan Hsiao, Michael Lennick, Paul Fletcher
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Publication number: 20070265189Abstract: Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, which are present on insulin and insulin-like growth factor receptors, and which selectively bind the peptides of this invention. As agonists, certain of the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonists may also be developed as therapeutics.Type: ApplicationFiled: July 10, 2007Publication date: November 15, 2007Applicants: Novo Nordisk A/S, Antyra Inc.Inventors: Renuka Pillutla, Renee Brissette, Arthur Blume, Lauge Schaffer, Jakob Brandt, Neil Goldstein, Jane Spetzler, Soren Ostergaard, Per Hansen
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Patent number: 7173005Abstract: Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, which are present on insulin and insulin-like growth factor receptors, and which selectively bind the peptides of this invention. As agonists, the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonist peptides may also be developed as therapeutics.Type: GrantFiled: September 24, 2002Date of Patent: February 6, 2007Assignees: Antyra Inc., Novo Nordisk A/SInventors: Renuka Pillutla, Olga Dedova, Arthur J. Blume, Neil I. Goldstein, Renee Brissette, Pinger Wang, Hao Liu, Ku-Chuan Hsiao, Michael Lennick, Paul Fletcher
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Publication number: 20070004634Abstract: Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, which are present on insulin and insulin-like growth factor receptors, and which selectively bind the peptides of this invention. As agonists, the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonist peptides may also be developed as therapeutics.Type: ApplicationFiled: April 24, 2006Publication date: January 4, 2007Applicants: Novo Nordisk A/S, Antyra Inc.Inventors: Renuka Pillutla, Olga Dedova, Arthur Blume, Neil Goldstein, Renee Brissette, Pinger Wang, Hao Liu, Ku-chuan Hsiao, Michael Lennick, Paul Fletcher
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Patent number: 7148193Abstract: The present invention provides peptides that bind to the active site of the growth hormone receptor. The present invention also provides methods of using these peptides to identify small organic molecules, which are novel agonists or antagonists of the growth hormone receptor. In addition, the present invention provides kits and therapeutic compositions comprising the peptides that bind to growth hormone receptor.Type: GrantFiled: April 4, 2002Date of Patent: December 12, 2006Assignee: Antyra, Inc.Inventors: Arthur J. Blume, Renee Brissette, Juan Carcamo, Wlodek S. Mandecki, Pauline M. Tang
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Publication number: 20060252697Abstract: The present invention provides peptides that bind to the active site of the growth hormone receptor. The present invention also provides methods of using these peptides to identify small organic molecules, which are novel agonists or antagonists of the growth hormone receptor. In addition, the present invention provides kits and therapeutic compositions comprising the peptides that bind to growth hormone receptor.Type: ApplicationFiled: April 4, 2002Publication date: November 9, 2006Inventors: Arthur Blume, Renee Brissette, Juan Carcamo, Wlodek Mandecki, Pauline Tang
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Patent number: 7056679Abstract: The invention relates to a modified phage display method for detecting and identifying target and target binders. The modified methods involve transforming host cells with two separate phages of a target or target library and a target-binder library, and selecting to eliminate the non-paired targets and binders. The invention also relates to antibodies that bind to complexes of target and target binders; nucleic acids encoding target and target binders peptides; and the use of sequence information inherent in the targets and target binders for target validation using in silico approaches. The invention further relates to diagnostics and therapeutics employing the disclosed target and target binder peptides or polynucletides and their use in small molecule drug discovery; diagnostic and therapeutic applications directed to cancers and similar disorders; and site directed assays for high throughput drug screening.Type: GrantFiled: October 24, 2002Date of Patent: June 6, 2006Assignee: Antyra, Inc.Inventors: Renuka Pillutla, Renee Brissette, Michael Spruyt, Olga Dedova, Arthur Blume, John Prendergast, Neil Goldstein
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Patent number: 6875741Abstract: Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, which are present on insulin and insulin-like growth factor receptors, and which selectively bind the peptides of this invention. As agonists, certain of the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonists may also be developed as therapeutics.Type: GrantFiled: September 24, 2001Date of Patent: April 5, 2005Inventors: Renuka Pillutla, Renee Brissette, Arthur J. Blume, Lauge Schäffer, Jakob Brandt, Neil I. Goldstein, Jane Spetzler, Søren Østergaard, Per Hertz Hansen
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Publication number: 20040023887Abstract: Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, which are present on insulin and insulin-like growth factor receptors, and which selectively bind the peptides of this invention. As agonists, the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonist peptides may also be developed as therapeutics.Type: ApplicationFiled: September 24, 2002Publication date: February 5, 2004Inventors: Renuka Pillutla, Olga Dedova, Arthur J. Blume, Neil I. Goldstein, Renee Brissette, Pinger Wang, Hao Liu, Ku-Chuan Hsiao, Michael Lennick, Paul Fletcher
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Publication number: 20030236190Abstract: Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, which are present on insulin and insulin-like growth factor receptors, and which selectively bind the peptides of this invention. As agonists, certain of the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonists may also be developed as therapeutics.Type: ApplicationFiled: September 24, 2002Publication date: December 25, 2003Inventors: Renuka Pillutla, Renee Brissette, Arthur J. Blume, Lauge Schaffer, Jacob Brandt, Neil I. Goldstein, Jane Spetzler, Soren Ostergaard, Per Hertz Hansen
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Publication number: 20030195147Abstract: Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, which are present on insulin and insulin-like growth factor receptors, and which selectively bind the peptides of this invention. As agonists, certain of the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonists may also be developed as therapeutics.Type: ApplicationFiled: September 24, 2001Publication date: October 16, 2003Inventors: Renuka Pillutla, Renee Brissette, Arthur J. Blume, Lauge Schaffer, Jakob Brandt, Neil I. Goldstein, Jane Spetzler, Soren Ostergaard, Per Hertz Hansen
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Publication number: 20030180718Abstract: The present invention relates to a modified phage display method for detecting and identifying target and target binders. The modified methods involve transforming host cells with two separate phages, one comprising a target or target library and the other comprising a target-binder library, and selecting to eliminate the non-paired targets and binders. Also related are complexes comprising target and target binders, as well as antibodies that bind to these complexes. Additionally, the present invention also relates to nucleic acids encoding target and target binders peptides. The invention also relates to the use of the sequence information inherent in the targets and target binders for target validation using in silico approaches. In addition, the invention also relates to diagnostics and therapeutics employing the disclosed target and target binder peptides or polynucletides and their use in small molecule drug discovery.Type: ApplicationFiled: October 24, 2002Publication date: September 25, 2003Inventors: Renuka Pillutla, Renee Brissette, Michael Spruyt, Olga Dedova, Arthur Blume, John Prendergast, Neil Goldstein
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Patent number: 6387879Abstract: The present invention provides peptides that bind to the active site of the growth hormone receptor. The present invention also provides methods of using these peptides to identify small organic molecules, which are novel agonists or antagonists of the growth hormone receptor. In addition, the present invention provides kits and therapeutic compositions comprising the peptides that bind to growth hormone receptor.Type: GrantFiled: December 15, 1997Date of Patent: May 14, 2002Assignee: DGI Biotechnologies, Inc.Inventors: Arthur J. Blume, Renee Brissette, Juan Carcamo, Wlodek S. Mandecki, Pauline M. Tang