Patents by Inventor Renee Caroline Roemmele
Renee Caroline Roemmele has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20140121182Abstract: The invention provides boronic esters of Formula (I) wherein R is H or methyl, and methods for the preparation and purification thereof.Type: ApplicationFiled: June 21, 2012Publication date: May 1, 2014Applicant: Cephalon, Inc.Inventors: Roger P. Bakale, John P. Mallamo, Renee Caroline Roemmele
-
Patent number: 8541590Abstract: The invention provides boronic esters of Formula I wherein R1, R2, R3, and R4 are as described herein, and methods for the preparation and purification thereof.Type: GrantFiled: June 20, 2012Date of Patent: September 24, 2013Assignee: Cephalon, Inc.Inventor: Renee Caroline Roemmele
-
Patent number: 8420829Abstract: New methods for the preparation of bendamustine, and the pharmaceutical salts thereof, are described. Novel compounds useful for the preparation of bendamustine are also described.Type: GrantFiled: April 5, 2011Date of Patent: April 16, 2013Assignee: Cephalon, Inc.Inventors: Jian Chen, Katrin Przyuski, Renee Caroline Roemmele
-
Publication number: 20120270840Abstract: The invention provides boronic esters of Formula I wherein R1, R2, R3, and R4 are as described herein, and methods for the preparation and purification thereof.Type: ApplicationFiled: June 20, 2012Publication date: October 25, 2012Applicant: Cephalon Inc.Inventor: Renee Caroline Roemmele
-
Publication number: 20110190509Abstract: New methods for the preparation of bendamustine, and the pharmaceutical salts thereof, are described. Novel compounds useful for the preparation of bendamustine are also described.Type: ApplicationFiled: April 5, 2011Publication date: August 4, 2011Applicant: Cephalon, Inc.Inventors: Jian Chen, Katrin Przyuski, Renee Caroline Roemmele
-
Patent number: 6307094Abstract: The present invention provides a solventless process for the catalytic hydrogenation of esters of 4,4,4-trihaloacetoacetic acid using a platinum catalyst in the presence of an acid or base co-catalyst to provide the analagous 3-hydroxybutyrate ester. Such 3-hydroxybutyrate esters are useful as solvents, cleaners or fine chemical intermediates.Type: GrantFiled: May 2, 2000Date of Patent: October 23, 2001Inventors: Joshua Anthony Chong, Fereydon Abdesaken, Lori Ann Spangler, Renee Caroline Roemmele, Randall Wayne Stephens, Peter David Nightingale, David John Hartley
-
Patent number: 6147220Abstract: This invention provides a process for the preparation of a 5-methylene-1,3-oxazoline from an alkyl ketone by reacting the alkyl ketone with an acetylating agent and an acid catalyst in an appropriate solvent and at an appropriate temperature. The resulting 5-methylene-1,3-oxazoline can be chlorinated and subsequently hydrolyzed to form an .alpha.-chloroketone which is useful as a fungicide.Type: GrantFiled: May 15, 1998Date of Patent: November 14, 2000Assignee: Rohm and Haas CompanyInventors: Renee Caroline Roemmele, Heather Lynnette Rayle
-
Patent number: 6087535Abstract: This invention provides an improved process for the preparation of chloroalkynes from alkynyl alcohols. The chloroalkynes can be employed to prepare alkynyl amines which are useful for the manufacture of biologically active materials. The present invention reduces the hazards of the chlorination reaction, eliminates or greatly reduces by-product formation, and provides certain environmental benefits.Type: GrantFiled: January 7, 1999Date of Patent: July 11, 2000Assignee: Rohm and Haas CompanyInventors: Renee Caroline Roemmele, Andrew William Gross, David Wayne Mosley
-
Patent number: 5977368Abstract: This invention relates to a process for the preparation of an .alpha.-chloroketone compound comprising the steps of(i) cyclizing an alkynyl amide to form a 5-methyleneoxazoline ##STR1## (ii) chlorinating the 5-methyleneoxazoline using trichloroisocyanuric acid to produce a chlorinated oxazoline intermediate ##STR2## and (iii) hydrolyzing the chlorinated oxazoline intermediate with an aqueous acid to produce the desired monochloroketone ##STR3## wherein Z is alkyl or substituted alkyl, aryl or substituted aryl, heteroaryl or substituted heteroaryl or phenylene,R is a hydrogen atom or alkyl, andR.sup.1 and R.sup.2 are each independently an alkyl or substituted alkyl group, or R.sup.1 and R.sup.2 together with the carbon atom to which they are attached form a cyclic structure.Additionally, when R is a hydrogen atom, a dichloroketone can be conveniently formed through adjustment of reaction conditions.Type: GrantFiled: October 13, 1998Date of Patent: November 2, 1999Assignee: Rohm and Haas CompanyInventors: Heather Lynnette Rayle, Renee Caroline Roemmele, Randall Wayne Stephens
-
Patent number: 5959114Abstract: This invention relates to a process for the preparation of an .alpha.-chloroketone compound comprising the steps of(i) cyclizing an alkynyl amide to form a 5-methyleneoxazoline ##STR1## (ii) chlorinating the 5-methyleneoxazoline using trichloroisocyanuric acid to produce a chlorinated oxazoline intermediate ##STR2## and (iii) hydrolyzing the chlorinated oxazoline intermediate with an aqueous acid to produce the desired monochloroketone ##STR3## wherein Z is alkyl or substituted alkyl, aryl or substituted aryl, heteroaryl or substituted heteroaryl or phenylene,R is a hydrogen atom or alkyl, andR.sup.1 and R.sup.2 are each independently an alkyl or substituted alkyl group, or R.sup.1 and R.sup.2 together with the carbon atom to which they are attached form a cyclic structure.Additionally, when R is a hydrogen atom, a dichloroketone can be conveniently formed through adjustment of reaction conditions.Type: GrantFiled: October 13, 1998Date of Patent: September 28, 1999Assignee: Rohm and Haas CompanyInventors: Heather Lynnette Rayle, Renee Caroline Roemmele, Randall Wayne Stephens
-
Patent number: 5942621Abstract: This invention relates to a process for the preparation of an .alpha.-chloroketone compound comprising the steps of(i) cyclizing an alkynyl amide to form a 5-methyleneoxazoline ##STR1## (ii) chlorinating the 5-methyleneoxazoline using trichloroisocyanuric acid to produce a chlorinated oxazoline intermediate ##STR2## and (iii) hydrolyzing the chlorinated oxazoline intermediate with an aqueous acid to produce the desired monochloroketone ##STR3## wherein Z is alkyl or substituted alkyl, aryl or substituted aryl, heteroaryl or substituted heteroaryl or phenylene,R is a hydrogen atom or alkyl, andR.sup.1 and R.sup.2 are each independently an alkyl or substituted alkyl group, or R.sup.1 and R.sup.2 together with the carbon atom to which they are attached form a cyclic structure.Additionally, when R is a hydrogen atom, a dichloroketone can be conveniently formed through adjustment of reaction conditions.Type: GrantFiled: October 13, 1998Date of Patent: August 24, 1999Assignee: Rohm and Haas CompanyInventors: Heather Lynnette Rayle, Renee Caroline Roemmele, Randall Wayne Stephens
-
Patent number: 5936096Abstract: This invention relates to a process for the preparation of an .alpha.-chloroketone compound comprising the steps of(i) cyclizing an alkynyl amide to form a 5-methyleneoxazoline ##STR1## (ii) chlorinating the 5-methyleneoxazoline using trichloroisocyanuric acid to produce a chlorinated oxazoline intermediate ##STR2## and (iii) hydrolyzing the chlorinated oxazoline intermediate with an aqueous acid to produce the desired monochloroketone ##STR3## wherein Z is alkyl or substituted alkyl, aryl or substituted aryl, heteroaryl or substituted heteroaryl or phenylene,R is a hydrogen atom or alkyl, andR.sup.1 and R.sup.2 are each independently an alkyl or substituted alkyl group, or R.sup.1 and R.sup.2 together with the carbon atom to which they are attached form a cyclic structure.Additionally, when R is a hydrogen atom, a dichloroketone can be conveniently formed through adjustment of reaction conditions.Type: GrantFiled: October 13, 1998Date of Patent: August 10, 1999Assignee: Rohm and Haas CompanyInventors: Heather Lynnette Rayle, Renee Caroline Roemmele, Randall Wayne Stephens
-
Patent number: 5932738Abstract: This invention relates to a process for the preparation of an .alpha.-chloroketone compound comprising the steps of(i) cyclizing an alkynyl amide to form a 5-methyleneoxazoline ##STR1## (ii) chlorinating the 5-methyleneoxazoline using trichloroisocyanuric acid to produce a chlorinated oxazoline intermediate ##STR2## and (iii) hydrolyzing the chlorinated oxazoline intermediate with an aqueous acid to produce the desired monochloroketone ##STR3## wherein Z is alkyl or substituted alkyl, aryl or substituted aryl, heteroaryl or substituted heteroaryl or phenylene,R is a hydrogen atom or alkyl andR.sup.1 and R.sup.2 are each independently an alkyl or substituted alkyl group, or R.sup.1 and R.sup.2 together with the carbon atom to which they are attached form a cyclic structure.Additionally, when R is a hydrogen atom, a dichloroketone can be conveniently formed through adjustment of reaction conditions.Type: GrantFiled: October 13, 1998Date of Patent: August 3, 1999Assignee: Rohm and Haas CompanyInventors: Heather Lynnette Rayle, Renee Caroline Roemmele, Randall Wayne Stephens
-
Patent number: 5929287Abstract: This invention relates to a process for the selective monochlorination or dichlorination of certain substituted alkenes using trichloroisocyanuric acid. The chlorinated alkenes can be easily hydrolyzed to provide .alpha.-monochloroketones or .alpha.,.alpha.-dichloroketones with a high degree of selectivity. The resulting .alpha.-monochloroketones or .alpha.,.alpha.-dichloroketones have utility as fungicides or function as useful intermediates for fungicides.Type: GrantFiled: April 13, 1998Date of Patent: July 27, 1999Assignee: Rohm and Haas CompanyInventors: Renee Caroline Roemmele, Heather Lynnette Rayle
-
Patent number: 5925763Abstract: This invention relates to a process for the preparation of an .alpha.-chloroketone compound comprising the steps of(i) cyclizing an alkynyl amide to form a 5-methyleneoxazoline ##STR1## (ii) chlorinating the 5-methyleneoxazoline using trichloroisocyanuric acid to produce a chlorinated oxazoline intermediate ##STR2## and (iii) hydrolyzing the chlorinated oxazoline intermediate with an aqueous acid top produce the desired monochloroketone ##STR3## wherein Z is alkyl or substituted alkyl, aryl or substituted aryl, heteroaryl or substituted heteroaryl or phenylene,R is a hydrogen atom or alkyl, andR.sup.1 and R.sup.2 are each independently an alkyl or substituted alkyl group, or R.sup.1 and R.sup.2 together with the carbon atom to which they are attached form a cyclic structure.Additionally, when R is a hydrogen atom, a dichioroketone can be conveniently formed through adjustment of reaction conditions.Type: GrantFiled: October 13, 1998Date of Patent: July 20, 1999Assignee: Rohm and Haas CompanyInventors: Heather Lynnette Rayle, Renee Caroline Roemmele, Randall Wayne Stephens
-
Patent number: 5922916Abstract: The present invention relates to a process for preparing 5-methylene cyclic carbamates either by cyclization of an alkynyl amine with carbon dioxide in the presence of a copper catalyst or by forming an isocyanate from a substituted acetoacetamide followed by hydrolysis. The 5-methylene cyclic carbamates by either method are converted to 5-(chloromethylene) cyclic carbamates, using trichloroisocyanuric acid, followed by hydrolysis to a chloroketoamine.The chloroketoamine from the process of this invention additionally can be reacted with an organic acid chloride to form an amide compound which is useful as a fungicide.Type: GrantFiled: April 13, 1998Date of Patent: July 13, 1999Assignee: Rohm and Haas CompanyInventors: Heather Lynnette Rayle, Renee Caroline Roemmele, Randall Wayne Stephens, Joshua Anthony Chong, Fereydon Abdesaken, Charles Chao Wu
-
Patent number: 5866513Abstract: Disclosed are herbicidal aryl substituted cycloalkyl and aryl substituted cycloalkenyl compounds, herbicidal compositions, and herbicidal use of the compounds and compositions. The aryl substituent is selected from substituted phenyl, unsubstituted or substituted five-membered heterocycle, and unsubstituted or substituted six-membered heterocycle.Type: GrantFiled: February 25, 1997Date of Patent: February 2, 1999Assignee: Rohm and Haas CompanyInventors: Enrique Luis Michelotti, Renee Caroline Roemmele, Colin Swithenbank, Colin Michael Tice, David Hamilton Young
-
Patent number: 5859254Abstract: This invention relates to a process for the preparation of an .alpha.-chloroketone compound comprising the steps of(i) cyclizing an alkynyl amide to form a 5-methyleneoxazoline ##STR1## (ii) chlorinating the 5-methyleneoxazoline using trichloroisocyanuric acid to produce a chlorinated oxazoline intermediate ##STR2## and (iii) hydrolyzing the chlorinated oxazoline intermediate with an aqueous acid to produce the desired monochloroketone ##STR3## wherein Z is alkyl or substituted alkyl, aryl or substituted aryl, heteroaryl or substituted heteroaryl or phenylene,R is a hydrogen atom or alkyl, andR.sup.1 and R.sup.2 are each independently an alkyl or substituted alkyl group, or R.sup.1 and R.sup.2 together with the carbon atom to which they are attached form a cyclic structure.Additionally, when R is a hydrogen atom, a dichloroketone can be conveniently formed through adjustment of reaction conditions.Type: GrantFiled: April 13, 1998Date of Patent: January 12, 1999Assignee: Rohm and Haas CompanyInventors: Heather Lynnette Rayle, Renee Caroline Roemmele, Randall Wayne Stephens
-
Patent number: 5783736Abstract: The process of this invention comprises a two step sequence wherein an alcohol is converted to an organic chloride through reaction with a chlorinating agent in a first step followed by amination of the organic chloride to the corresponding amine in a second step. In the second step, a surfactant is employed in order to facilitate the reaction.Type: GrantFiled: September 26, 1997Date of Patent: July 21, 1998Assignee: Rohm and Haas CompanyInventors: Randall Wayne Stephens, Renee Caroline Roemmele
-
Patent number: 5726124Abstract: A class of 2-arylpyrimidines which is useful in the control of weeds of the general formula: ##STR1## wherein R.sup.2 is an optionally substituted aromatic ring; R.sup.3 is a saturated or unsaturated alkyl group; R.sup.5 is selected from acyl, alkoxyalkyl, alkoxyimino, dialkoxyalkyl, formyl, hydroxyalkyl, alkoxyalkoxy, cyanoalkyl and hydroxyimino; R.sup.6 is selected from hydrogen, halo, alkyl, haloalkyl, aryl, and alkoxy; and X is oxygen or sulfur.Type: GrantFiled: October 28, 1994Date of Patent: March 10, 1998Assignee: Rohm and Haas CompanyInventors: Colin Michael Tice, Vincent Angelo Musco, Renee Caroline Roemmele, Harlow Lester Warner