Patents by Inventor Renfeng Guo

Renfeng Guo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-C5a Binding Moieties With High Blocking Activity
    Publication number: 20150266949
    Abstract: The present invention relates to binding moieties that specifically bind to a conformational epitope of C5a, in particular human C5a. Preferred binding moieties are anti-C5a antibodies that bind to this conformational epitope. The binding moieties described herein are useful as active agents in pharmaceutical compositions for the treatment and prevention of various acute and chronic diseases, in particular acute inflammatory diseases, such as the systemic inflammatory response syndrome (SIRS), and different degrees of sepsis including sepsis, severe sepsis, and septic shock.
    Type: Application
    Filed: June 3, 2015
    Publication date: September 24, 2015
    Inventors: Renfeng GUO, Niels Christoph RIEDEMANN, Yan LI, Beifen SHEN
  • Anti-C5A binding moieties with high blocking activity
    Patent number: 9073983
    Abstract: The present invention relates to binding moieties that specifically bind to a conformational epitope of C5a, in particular human C5a. Preferred binding moieties are anti-C5a antibodies that bind to this conformational epitope. The binding moieties described herein are useful as active agents in pharmaceutical compositions for the treatment and prevention of various acute and chronic diseases, in particular acute inflammatory diseases, such as the systemic inflammatory response syndrome (SIRS), and different degrees of sepsis including sepsis, severe sepsis, and septic shock.
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: July 7, 2015
    Assignee: INFLARX GMBH
    Inventors: Renfeng Guo, Niels Cristoph Riedemann, Yan Li, Beifen Shen
  • ANTI-C5A BINDING MOIETIES WITH HIGH BLOCKING ACTIVITY
    Publication number: 20140314772
    Abstract: The present invention relates to binding moieties that specifically bind to a conformational epitope of C5a, in particular human C5a. Preferred binding moieties are anti-C5a antibodies that bind to this conformational epitope. The binding moieties described herein are useful as active agents in pharmaceutical compositions for the treatment and prevention of various acute and chronic diseases, in particular acute inflammatory diseases, such as the systemic inflammatory response syndrome (SIRS), and different degrees of sepsis including sepsis, severe sepsis, and septic shock.
    Type: Application
    Filed: June 27, 2014
    Publication date: October 23, 2014
    Inventors: Renfeng GUO, Niels Cristoph RIEDEMANN, Yan LI, Beifen SHEN
  • Anti-C5a binding antibodies with high block activity
    Patent number: 8802096
    Abstract: The present invention relates to binding moieties that specifically bind to a conformational epitope of C5a, in particular human C5a. Preferred binding moieties are anti-C5a antibodies that bind to this conformational epitope. The binding moieties described herein are useful as active agents in pharmaceutical compositions for the treatment and prevention of various acute and chronic diseases, in particular acute inflammatory diseases, such as the systemic inflammatory response syndrome (SIRS), and different degrees of sepsis including sepsis, severe sepsis, and septic shock.
    Type: Grant
    Filed: November 26, 2010
    Date of Patent: August 12, 2014
    Assignee: Inflarx GmbH
    Inventors: Renfeng Guo, Niels Christoph Riedemann, Yan Li, Beifen Shen
  • Anti-C5A Binding Moieties with High Blocking Activity
    Publication number: 20120231008
    Abstract: The present invention relates to binding moieties that specifically bind to a conformational epitope of C5a, in particular human C5a. Preferred binding moieties are anti-C5a antibodies that bind to this conformational epitope. The binding moieties described herein are useful as active agents in pharmaceutical compositions for the treatment and prevention of various acute and chronic diseases, in particular acute inflammatory diseases, such as the systemic inflammatory response syndrome (SIRS), and different degrees of sepsis including sepsis, severe sepsis, and septic shock.
    Type: Application
    Filed: November 26, 2010
    Publication date: September 13, 2012
    Inventors: Renfeng Guo, Niels Christoph Reidemann, Yan Li, Beifen Shen
  • Compositions and methods for the diagnosis and treatment of sepsis
    Patent number: 7455837
    Abstract: The present invention relates to methods and compositions for the diagnosis and treatment of sepsis. The present invention also provides methods of providing a prognosis to a patient with sepsis. In particular, the present invention relates to compositions and methods for the detection of C5aR expression and the correlation of C5aR expression level with prognosis in sepsis.
    Type: Grant
    Filed: November 5, 2003
    Date of Patent: November 25, 2008
    Assignee: The Regents of the University of Michigan
    Inventors: Renfeng Guo, Niels C. Riedemann, Peter A. Ward, Markus Huber-Lang, J. Vidya Sarma
  • Compositions and methods for the diagnosis and treatment of sepsis
    Publication number: 20040166541
    Abstract: The present invention relates to methods and compositions for the diagnosis and treatment of sepsis. The present invention also provides methods of providing a prognosis to a patient with sepsis. In particular, the present invention relates to compositions and methods for the detection of C5aR expression and the correlation of C5aR expression level with prognosis in sepsis.
    Type: Application
    Filed: November 5, 2003
    Publication date: August 26, 2004
    Applicant: The Regents of the University of Michigan
    Inventors: Renfeng Guo, Niels C. Riedemann, Peter A. Ward, Markus Huber-Lang, J. Vidya Sarma