Abstract: Disclosed are a hand-operated juicer, a drive screw capable of rotating around an axis of the drive screw and moving forward and backward, and a juicing assembly of the hand-operated juicer. The juicing assembly includes a juicing head, and a juicing cover connected to a shell. The juicing head is capable of being accommodated in a squeezing cavity, an outer surface of the juicing head is an arc-shaped surface and is provided with a plurality of outer convex ribs, and the juicing cover is provided with an arc-shaped concave juicing head capable of accommodating the squeezing cavity. The drive screw rotates towards a front end for squeezing in the juicing process, thereby achieving the effects of more complete juicing, high juice yield and labor-saving operation. It is unnecessary to peel fruit, thereby facilitating the juicing operation.