Patents by Inventor Renius Owen
Renius Owen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11959143Abstract: Provided herein are methods for miRNA profiling for the diagnosis, prognosis, and management of melanoma and differentiation of melanoma from nevi.Type: GrantFiled: November 24, 2020Date of Patent: April 16, 2024Assignee: Quest Diagnostics Investments LLCInventors: Kevin Qu, Anthony Sferruzza, Ke Zhang, Yan Liu, Renius Owen
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Publication number: 20210147947Abstract: Provided herein are methods for miRNA profiling for the diagnosis, prognosis, and management of melanoma and differentiation of melanoma from nevi.Type: ApplicationFiled: November 24, 2020Publication date: May 20, 2021Applicant: Quest Diagnostics Investments LLCInventors: Kevin Qu, Anthony Sferruzza, Ke Zhang, Yan Liu, Renius Owen
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Patent number: 10851424Abstract: Provided herein are methods for miRNA profiling for the diagnosis, prognosis, and management of melanoma and differentiation of melanoma from nevi.Type: GrantFiled: August 20, 2018Date of Patent: December 1, 2020Assignee: Quest Diagnostics Investments LLCInventors: Kevin Qu, Anthony Sferruzza, Ke Zhang, Yan Liu, Renius Owen
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Publication number: 20200255896Abstract: The present disclosure provides methods for non-invasive prenatal screening (NIPS) of fetal aneuploidies. The present methods are based on analyzing cell-free fetal DNA (cff DNA) found in a pregnant woman's circulation through the next generation sequencing (NGS) technology. Particularly, the present methods analyze the relative abundance of different fetal genomic fragments present in the maternal sample, where the fragments can be aligned to particular chromosomal locations of the fetal genome. The relative abundance information is indicative as to whether a particular chromosome is overrepresented or underrepresented in a fetal genome as compared to normal individuals, and thus can be used to detect fetal aneuploidy. Additionally, methods for increasing the positive predictive values (PPV) of NIPS by excluding false-positive detections are also provided.Type: ApplicationFiled: January 10, 2018Publication date: August 13, 2020Applicant: QUEST DIAGNOSTICS INVESTMENTS LLCInventors: Charles Rowland, Renius Owen, Charles Strom, Ke Zhang
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Publication number: 20190062844Abstract: Provided herein are methods for miRNA profiling for the diagnosis, prognosis, and management of melanoma and differentiation of melanoma from nevi.Type: ApplicationFiled: August 20, 2018Publication date: February 28, 2019Applicant: Quest Diagnostics Investments LLCInventors: Kevin Qu, Anthony Sferruzza, Ke Zhang, Yan Liu, Renius Owen
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Patent number: 10053738Abstract: Provided herein are methods for miRNA profiling for the diagnosis, prognosis, and management of melanoma and differentiation of melanoma from nevi.Type: GrantFiled: August 18, 2016Date of Patent: August 21, 2018Assignee: Quest Diagnostics Investments IncorporatedInventors: Kevin Qu, Anthony Sferruzza, Ke Zhang, Yan Liu, Renius Owen
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Patent number: 9988689Abstract: Provided herein are methods for miRNA profiling for the diagnosis, prognosis, and management of melanoma and differentiation of melanoma from nevi.Type: GrantFiled: August 5, 2016Date of Patent: June 5, 2018Assignee: QUEST DIAGNOSTICS INVESTMENTS INCORPORATEDInventors: Kevin Qu, Anthony Sferruzza, Ke Zhang, Yan Liu, Renius Owen
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Publication number: 20170088899Abstract: Provided herein are methods for miRNA profiling for the diagnosis, prognosis, and management of melanoma and differentiation of melanoma from nevi.Type: ApplicationFiled: August 5, 2016Publication date: March 30, 2017Applicant: Quest Diagnostics Investments IncorporatedInventors: Kevin Qu, Anthony Sferruzza, Ke Zhang, Yan Liu, Renius Owen
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Publication number: 20170081725Abstract: Provided herein are methods for miRNA profiling for the diagnosis, prognosis, and management of melanoma and differentiation of melanoma from nevi.Type: ApplicationFiled: August 18, 2016Publication date: March 23, 2017Applicant: Quest Diagnostics Investments IncorporatedInventors: Kevin Qu, Anthony Sferruzza, Ke Zhang, Yan Liu, Renius Owen
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Patent number: 9447471Abstract: Provided herein are methods for miRNA profiling for the diagnosis, prognosis, and management of melanoma and differentiation of melanoma from nevi.Type: GrantFiled: December 27, 2012Date of Patent: September 20, 2016Assignee: QUEST DIAGNOSTICS INVESTMENTS INCORPORATEDInventors: Kevin Qu, Anthony Sferruzza, Ke Zhang, Yan Liu, Renius Owen
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Patent number: 8492089Abstract: Provided are methods of determining differences between nucleic acids in a test sample and a reference sample. In certain embodiments the methods are used for detecting and mapping chromosomal or genetic abnormalities associated with various diseases or with predisposition to various diseases, or to detecting the phenomena of large scale copy number variants. In particular, provided are advanced methods of performing array-based comparative hybridization that allow reproducibility between samples and enhanced sensitivity by using the same detectable label for both test sample and reference sample nucleic acids. Invention methods are useful for the detection or diagnosis of particular disease conditions such as cancer, and detecting predisposition to cancer based on detection of chromosomal or genetic abnormalities and gene expression level. Invention methods are also useful for the detection or diagnosis of hereditary genetic disorders or predisposition thereto, especially in prenatal samples.Type: GrantFiled: February 16, 2011Date of Patent: July 23, 2013Assignee: Quest Diagnostics Investments IncorporatedInventors: Renius Owen, Charles M. Strom
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Publication number: 20110143957Abstract: Provided are methods of determining differences between nucleic acids in a test sample and a reference sample. In certain embodiments the methods are used for detecting and mapping chromosomal or genetic abnormalities associated with various diseases or with predisposition to various diseases, or to detecting the phenomena of large scale copy number variants. In particular, provided are advanced methods of performing array-based comparative hybridization that allow reproducibility between samples and enhanced sensitivity by using the same detectable label for both test sample and reference sample nucleic acids. Invention methods are useful for the detection or diagnosis of particular disease conditions such as cancer, and detecting predisposition to cancer based on detection of chromosomal or genetic abnormalities and gene expression level. Invention methods are also useful for the detection or diagnosis of hereditary genetic disorders or predisposition thereto, especially in prenatal samples.Type: ApplicationFiled: February 16, 2011Publication date: June 16, 2011Inventors: Renius Owen, Charles M. Strom
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Publication number: 20090155809Abstract: Provided are methods of determining differences between nucleic acids in a test sample and a reference sample. In certain embodiments the methods are used for detecting and mapping chromosomal or genetic abnormalities associated with various diseases or with predisposition to various diseases, or to detecting the phenomena of large scale copy number variants. In particular, provided are advanced methods of performing array-based comparative hybridization that allow reproducibility between samples and enhanced sensitivity by using the same detectable label for both test sample and reference sample nucleic acids. Invention methods are useful for the detection or diagnosis of particular disease conditions such as cancer, and detecting predisposition to cancer based on detection of chromosomal or genetic abnormalities and gene expression level. Invention methods are also useful for the detection or diagnosis of hereditary genetic disorders or predisposition thereto, especially in prenatal samples.Type: ApplicationFiled: February 25, 2009Publication date: June 18, 2009Inventors: Renius Owen, Charles M. Strom
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Patent number: 7507539Abstract: Provided are methods of determining differences between nucleic acids in a test sample and a reference sample. In certain embodiments the methods are used for detecting and mapping chromosomal or genetic abnormalities associated with various diseases or with predisposition to various diseases, or to detecting the phenomena of large scale copy number variants. In particular, provided are advanced methods of performing array-based comparative hybridization that allow reproducibility between samples and enhanced sensitivity by using the same detectable label for both test sample and reference sample nucleic acids. Invention methods are useful for the detection or diagnosis of particular disease conditions such as cancer, and detecting predisposition to cancer based on detection of chromosomal or genetic abnormalities and gene expression level. Invention methods are also useful for the detection or diagnosis of hereditary genetic disorders or predisposition thereto, especially in prenatal samples.Type: GrantFiled: July 30, 2007Date of Patent: March 24, 2009Assignee: Quest Diagnostics Investments IncorporatedInventors: Renius Owen, Charles M. Strom
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Publication number: 20090035757Abstract: Provided are methods of determining differences between nucleic acids in a test sample and a reference sample. In certain embodiments the methods are used for detecting and mapping chromosomal or genetic abnormalities associated with various diseases or with predisposition to various diseases, or to detecting the phenomena of large scale copy number variants. In particular, provided are advanced methods of performing array-based comparative hybridization that allow reproducibility between samples and enhanced sensitivity by using the same detectable label for both test sample and reference sample nucleic acids. Invention methods are useful for the detection or diagnosis of particular disease conditions such as cancer, and detecting predisposition to cancer based on detection of chromosomal or genetic abnormalities and gene expression level. Invention methods are also useful for the detection or diagnosis of hereditary genetic disorders or predisposition thereto, especially in prenatal samples.Type: ApplicationFiled: July 30, 2007Publication date: February 5, 2009Inventors: Renius Owen, Charles M. Strom