Abstract: The invention relates to a HLA-B57 open conformer or a HLA-B57 Fc fusion protein for use in the treatment or prevention of cancer. The Fc open conformer comprises or consists of a first and a second monomer, and each monomer comprises a HLA-B57 chain. The Fc fusion protein further comprises a protein stabilizing polypeptide sequence and optionally an amino acid linker. Further aspects of the invention provide combination medicaments comprising the HLA-B57 Fc open conformer and immune checkpoint inhibitors and/or checkpoint agonist agents. Furthermore, the invention relates to the use of HLA-B57 open conformer as an immunomodulator, particularly in diseases where modulation of diverse immune cell components (e.g. cytotoxic CD8+ T cells, Tregs) is a therapeutic strategy, e.g. infectious diseases.

Abstract: A gearbox has an input shaft, an output shaft, three shifting elements, and three planetary gearsets each having a sun shaft, ring gear shaft, and web shaft. The first sun shaft, the second sun shaft, and the input shaft are connected rotationally fixed. Rotationally fixed connections are made between the first ring gear shaft and a stationary component, the first web shaft and the second ring gear shaft, the second web shaft and the third sun shaft, and the third web shaft and the output shaft. Closing the first shifting element connects the third ring gear shaft rotationally fixed to a stationary component. Closing the second shifting element connects in a rotationally fixed manner the first web shaft, the second ring gear shaft, the third web shaft, and the output shaft. Closing the third shifting element connects rotationally fixed two of the three shafts of the third planetary gearset.

Abstract: A vehicle gearbox has an input shaft for an electric machine, an output shaft, an interlocking shifting unit having first and second shifting elements, and a single axially displaceable sliding sleeve. First and second planetary gearsets each have a sun shaft, a ring gear shaft, and a web shaft. The first sun shaft, the second sun shaft, and the drive input shaft are connected rotationally fixed to one another, the first ring gear shaft is connected rotationally fixed to a stationary component; and the first web shaft is connected rotationally fixed to the second ring gear shaft. Closing the first shifting element engages a first gear where the first web shaft, second ring gear shaft, and output shaft connected rotationally fixed to one another. Closing the second shifting element engages a second gear where the second web shaft and output shaft are connected rotationally fixed to one another.

Abstract: The invention provides for an oligonucleotide lipid group conjugate, wherein the oligonucleotide comprises at least two alpha anomeric bicyclo-DNA residues connected by a phosphodiester bond, and wherein the lipid group is attached to the oligonucleotide via a linker. The invention also provides for methods of modulating gene expression using an oligonucleotide lipid group conjugate.

Abstract: The invention relates to a method for producing an aerogel under increased pressure, to the aerogel obtained using said method and to their use.

Abstract: Fuel cell lifting systems for nuclear reactors are disclosed. A fuel cell lifting system includes a radiation shield comprising: a first plate defining a first plane and comprising one or more first openings; and a second plate defining a second plane parallel to the first plane and comprising one or more second openings. At least one of the first plate or the second plate is rotatable around an axis perpendicular to the first plane and the second plane. A first opening of the first plate can be aligned with a second opening of the second plate to form a combined opening. A lifting motor is configured to extend and retract a tether through the combined opening of the radiation shield. The tether is attachable to a nuclear fuel cell.

Abstract: A connection bridge device is suggested for connecting a multipoint link to a vehicle axle, particularly a multipart vehicle axle. The connection bridge device comprises at least one base body for receiving and dissipating forces and/or torques transmitted between the vehicle axle and the multipoint link, at least one axle fastening unit for fastening the base body to the vehicle axle, and at least one link coupling unit for coupling the base body to the multipoint link, which link coupling unit is intersected by a main extension plane of the base body.

Abstract: A surgical instrument includes a housing and a trigger assembly. The trigger assembly includes a trigger including a drive portion and a manipulation portion, a rocker, a linkage, and a slider. The trigger is pivotably coupled to the housing such that the drive and manipulation portions are moved in different directions in response to actuation of the trigger. The drive portion of the trigger is pivotably coupled to the rocker. The linkage is pivotably coupled to the rocker and the housing at opposing end portions thereof. The slider is pivotably coupled to the rocker and operably coupled to the deployable component. Actuation of the manipulation portion of the trigger moves the drive portion of the trigger distally to thereby urge the rocker distally, pivot the linkage about the second end portion thereof, and slide the slider distally to deploy the deployable component distally.

Abstract: A motor vehicle transmission (2) has a first drive input shaft (9), a second drive input shaft (10), a drive output shaft (11), and a first planetary gearset (P1) and a second planetary gearset (P2). The drive input shafts (9, 10) are designed to be coupled in each case to a respective drive machine. In addition, a first shifting device (26) and a second shifting device (27) are provided. The motor vehicle transmission can be part of a drive unit (1), a motor vehicle drive axle, or a hybrid or electric vehicle. A method for operating a motor vehicle transmission and a drive unit is also disclosed.

Abstract: A method for operating a machine tool with a gentle start-up, preferably a jigsaw wherein at least one physical characteristic of the machine tool, in particular a motor and/or battery current, is detected by a detection unit, in particular a control or regulating unit of the machine tool, in an idle operating state of the machine tool with a throttled movement. A threshold of the physical characteristic, in particular a scraping threshold, is ascertained by an analysis unit, in particular the control or regulating unit of the machine tool, on the basis of the detected physical characteristic, and in further operation of the machine tool, a drive unit of the machine tool is set to an operating state under load, with a movement speed which is increased relative to the idle operating state with a throttled movement, when it is detected that the ascertained threshold has been overshot or undershot.

Abstract: Systems and methods for a welding-type power supply to provide both a welding output voltage and a battery charging output voltage. The power supply includes a first contactor associated with a first circuit to provide the welding output voltage, and a second contactor associated with a second circuit to provide the battery charging output voltage. An auxiliary switch is operatively coupled to the second contactor, to prevent the first circuit from closing when the second contactor is closed to prevent transmission of the welding output voltage to the second circuit.

Abstract: An electric vehicle transmission has a drive input shaft, a drive output shaft, where the input shaft is provided for coupling to an electric machine. First, second, and third planetary gearsets each comprise a first element, a second element, and a third element, respectively, in the form of a sun gear, a planetary web, and a ring gear in each case. At least functionally a first shifting element, a second shifting element, and a third shifting element are provided. The first element of the first planetary gearset is connected rotationally fixed to the drive input shaft. In addition, to produce the function of a parking brake, the third shifting element is provided, by means of which two of the elements of the second planetary gearset or of the third planetary gearset can be connected rotationally fixed to one another.

Abstract: Device D for cultivating cell cultures C, wherein said device D has a surface O and comprises on its surface O at least one polymer P wherein said polymer P is a copolymer of at least one monomer M and at least one ester E of (meth)acrylic acid and polyethylene oxide, wherein said monomer M is different from ester E and has at least one ethylenically unsaturated double bond.

Abstract: A method for dyeing leather with an organic colorant in a supercritical fluid. The method includes coating a surface of the leather to provide a coated surface of the leather. The method further includes dyeing the coated surface of the leather with the organic colorant in the supercritical fluid.

Abstract: Methods of additive manufacturing, binder compositions for additive manufacturing, and articles produced by and/or associated with methods of additive manufacturing are generally described.

Abstract: An eyewear device for reducing the spatial requirements of embedded circuit boards may comprise (1) a temple that comprises an at least partial cavity, (2) a circuit board placed inside the at least partial cavity of the temple, and (3) at least one antenna that is (A) placed inside the at least partial cavity of the temple, (B) commutatively coupled to the circuit board, and (C) offset from the circuit board. Various other apparatuses, systems, and methods are also disclosed.

Abstract: A method for manufacturing a composite material includes forming a composite precursor material comprising a nonwoven layer comprising a plurality of fibers and a polymer film layer laminated to the nonwoven layer; forming a plurality of apertured extended cells in the polymer film layer, each of the apertured extended cells having a continuous sidewall extending away from the nonwoven layer that terminates in an aperture at a distal end; and, while forming the plurality of apertured extended cells, pushing, with a fluid, at least one of the fibers into at least one of the apertured extended cells so that a portion of the at least one of the fibers extends into the at least one of the apertured extended cells and through the aperture at the distal end.

Abstract: A wheel (1) for a vehicle and a related method for manufacturing the wheel includes a rim (2) and a wheel center (3). The wheel center includes several spokes (4) extending from a hub (5), with a center opening (6), radially outwards to the rim (2). The hub (5) is made from a fiber-reinforced plastic material and is covered on the outboard side from a three-dimensionally shaped support cover (7) made from metallic material.

Abstract: A connection bridge device is suggested for connecting a multipoint link to a vehicle axle, particularly a multipart vehicle axle. The connection bridge device comprises at least one base body for receiving and dissipating forces and/or torques transmitted between the vehicle axle and the multipoint link, at least one axle fastening unit for fastening the base body to the vehicle axle, and at least one link coupling unit for coupling the base body to the multipoint link, which link coupling unit is intersected by a main extension plane of the base body.

Abstract: The present invention relates to medical uses and methods of treatment employing satraplatin. These medical uses are beneficial in treatment of cancers, particularly haematological malignancies. The invention also relates to methods of patient stratification and methods for the selection of treatment regimens, as well as to diagnostic methods and to biomarker panels.