Abstract: Disclosed in this invention are methods, systems, databases, user-interfaces, software, media, and services useful for evaluating interactions between chemical compounds and proteins and for utilizing the information resulting from such evaluation for the purpose of discovering chemical compounds for medical and other fields. An approach termed “reverse proteomics” is disclosed. This invention generates an enormously large pool of new target proteins for drug discovery, novel methods for designing of new drugs, and a previously unthinkable pool of virtually synthesized small molecules for therapeutic uses. This invention is also applicable, for example, to discovery of substitutes for environmentally hazardous chemicals, more effective agrochemicals, and healthier food additives.

Abstract: This invention provides libraries of information on chemical substances (which are termed “chenes”) as they interact with various biological systems, efficient methods to construct such libraries, and data sharing systems which enable efficient utilization of such libraries. Furthermore, this invention provides data bases which accommodate and maintain libraries of information relative to such chenes, methods and systems to construct such data bases by accumulating those pieces of information which concern chenes as they interact with various biological systems, methods and systems to enable a client to search through such construed data bases for desired information, methods and systems to transmit to such a client such desired pieces of information concerning chenes that are housed in such data bases, tangible electronic means to record and make use of such systems and data bases, and apparatus to enable construction and search of such data bases and/or transmission of desired information to such a client.

Abstract: In the detection of a genetic polymorphism using a mass spectrometer, a genomic DNA containing target polymorphism can be separated from a DNA sample and bound at the same time onto a platform by the following steps: binding an oligonucleotide that hybridizes with the genomic DNA containing the target polymorphism to the platform; and then applying the genomic DNA sample to the platform. Thus, a target polymorphism can be more efficiently detected. According to the method of the present invention, polymorphisms in a large number of specimens can be quickly and comprehensively detected.

Abstract: Disclosed in this invention are methods, systems, databases, user-interfaces, software, media, and services useful for evaluating interactions between chemical compounds and proteins and for utilizing the information resulting from such evaluation for the purpose of discovering chemical compounds for medical and other fields. An approach termed “reverse proteomics” is disclosed. This invention generates an enormously large pool of new target proteins for drug discovery, novel methods for designing of new drugs, and a previously unthinkable pool of virtually synthesized small molecules for therapeutic uses. This invention is also applicable, for example, to discovery of substitutes for environmentally hazardous chemicals, more effective agrochemicals, and healthier food additives.

Abstract: This invention provides libraries of information on chemical substances (which are termed “chenes”) as they interact with various biological systems, efficient methods to construct such libraries, and data sharing systems which enable efficient utilization of such libraries.