Patents by Inventor Renzo GRAZIOSI

Renzo GRAZIOSI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR PREPARING A FARNESOID X RECEPTOR AGONIST
    Publication number: 20200339622
    Abstract: The invention relates to a process for preparing a compound of formula (I) in particular obeticholic acid and intermediates suitable for its synthesis.
    Type: Application
    Filed: July 15, 2020
    Publication date: October 29, 2020
    Applicant: DIPHARMA FRANCIS S.r.l.
    Inventors: Gabriele RAZZETTI, Anna IULIANO, Luca GIANNOTTI, Grazia IANNUCCI, Emanuele ATTOLINO, Vittorio LUCCHINI, Renzo GRAZIOSI
  • Method for preparing a farnesoid X receptor agonist
    Patent number: 10752654
    Abstract: The invention relates to a process for preparing a compound of formula (I) in particular obeticholic acid and intermediates suitable for its synthesis.
    Type: Grant
    Filed: April 3, 2017
    Date of Patent: August 25, 2020
    Assignee: Dipharma Francis S.R.L.
    Inventors: Gabriele Razzetti, Anna Iuliano, Luca Giannotti, Grazia Iannucci, Emanuele Attolino, Vittorio Lucchini, Renzo Graziosi
  • METHOD FOR PREPARING A FARNESOID X RECEPTOR AGONIST
    Publication number: 20190106455
    Abstract: The invention relates to a process for preparing a compound of formula (I) in particular obeticholic acid and intermediates suitable for its synthesis.
    Type: Application
    Filed: April 3, 2017
    Publication date: April 11, 2019
    Applicant: DIPHARMA FRANCIS S.r.l.
    Inventors: Gabriele RAZZETTI, Anna IULIANO, Luca GIANNOTTI, Grazia IANNUCCI, Emanuele ATTOLINO, Vittorio LUCCHINI, Renzo GRAZIOSI
  • Antimuscarinic compound having a low content of impurities
    Patent number: 9751828
    Abstract: Substantially stable to degradation Fesoterodine fumarate, a process for its preparation and a process for the synthesis of specific degradation impurities of Fesoterodine fumarate are disclosed.
    Type: Grant
    Filed: June 23, 2015
    Date of Patent: September 5, 2017
    Assignee: Dipharma Francis S.r.l.
    Inventors: Pietro Allegrini, Emanuele Attolino, Renzo Graziosi
  • Crystalline forms of an antidepressant compound
    Patent number: 9687484
    Abstract: The present invention relates to novel crystalline forms of vortioxetine hydrobromide, in particular three crystalline forms, a process for their preparation, a pharmaceutical composition containing said novel crystalline forms, and a process for the purification of vortioxetine or a salt thereof, comprising the formation of one or more of the novel crystalline forms of vortioxetine hydrobromide described herein.
    Type: Grant
    Filed: July 6, 2015
    Date of Patent: June 27, 2017
    Assignee: Dipharma Francis S.r.l.
    Inventors: Stefano Luca Giaffreda, Marco Curzi, Elena Dichiarante, Pietro Allegrini, Renzo Graziosi, Chiara Vladiskovic
  • Process for the preparation of an antidepressant and the intermediates thereof
    Patent number: 9550743
    Abstract: The present invention relates to a process for the preparation of 1-[2-(2,4-dimethylphenylsulphanyl)phenyl]piperazine of formula (I), also known as vortioxetine, salts thereof, and intermediates useful for its synthesis.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: January 24, 2017
    Assignee: Dipharma Francis S.r.l.
    Inventors: Luca Giannotti, Renzo Graziosi, Emanuele Attolino, Pietro Allegrini
  • PROCESS FOR THE PREPARATION OF AN ANTIDEPRESSANT AND THE INTERMEDIATES THEREOF
    Publication number: 20160145224
    Abstract: The present invention relates to a process for the preparation of 1-[2-(2,4-dimethylphenylsulphanyl)phenyl]piperazine of formula (I), also known as vortioxetine, salts thereof, and intermediates useful for its synthesis.
    Type: Application
    Filed: November 19, 2015
    Publication date: May 26, 2016
    Applicant: DIPHARMA FRANCIS s.r.l.
    Inventors: Luca GIANNOTTI, Renzo GRAZIOSI, Emanuele ATTOLINO, Pietro ALLEGRINI
  • ANTIMUSCARINIC COMPOUND HAVING A LOW CONTENT OF IMPURITIES
    Publication number: 20160031796
    Abstract: Substantially stable to degradation Fesoterodine fumarate, a process for its preparation and a process for the synthesis of specific degradation impurities of Fesoterodine fumarate are disclosed.
    Type: Application
    Filed: June 23, 2015
    Publication date: February 4, 2016
    Applicant: Dipharma Francis S.r.l.
    Inventors: Pietro ALLEGRINI, Emanuele ATTOLINO, Renzo GRAZIOSI
  • CRYSTALLINE FORMS OF AN ANTIDEPRESSANT COMPOUND
    Publication number: 20160015706
    Abstract: The present invention relates to novel crystalline forms of vortioxetine hydrobromide, in particular three crystalline forms, a process for their preparation, a pharmaceutical composition containing said novel crystalline forms, and a process for the purification of vortioxetine or a salt thereof, comprising the formation of one or more of the novel crystalline forms of vortioxetine hydrobromide described herein.
    Type: Application
    Filed: July 6, 2015
    Publication date: January 21, 2016
    Applicant: DIPHARMA FRANCIS S.r.l.
    Inventors: Stefano Luca GIAFFREDA, Marco CURZI, Elena DICHIARANTE, Pietro ALLEGRINI, Renzo GRAZIOSI, Chiara VLADISKOVIC