Abstract: Provided herein are IL-12p40 and IL-12p35 polypeptides and compositions (e.g., pharmaceutical compositions) comprising the same; as well as methods of making the IL-12p40 and IL-12p35 polypeptides and compositions. Further provided herein are fusion proteins (e.g., antibody fusion proteins) that comprise an IL-12p40 polypeptide (e.g., an IL-12p40 polypeptide described herein) and/or IL-12p35 polypeptide (e.g., an IL-12p35 polypeptide described herein). The IL-12p40 polypeptides, IL-12p35 polypeptides, and fusion proteins provided herein are useful in pharmaceutical compositions and methods of treating diseases (e.g., cancer).

Abstract: Provided herein are multispecific proteins and compositions (e.g., pharmaceutical compositions) comprising the same; as well as methods of making the multispecific proteins and compositions. The multispecific proteins provided herein are useful in pharmaceutical compositions and methods, including, e.g., methods of treating diseases (e.g., cancer), methods of activating T-cells, and methods of inducing or enhancing an immune response.

Abstract: The present invention provides for a composition and a method for treating a subject afflicted with a cancer, wherein the composition comprises therapeutically effective amounts of: (a) an anti-Programmed Death-Ligand 1 (PD-L1) antibody and (b) a targeted/immunomodulatory fusion protein comprising at least one tumor targeting moiety and at least one immunomodulatory moiety that counteracts the immune tolerance of cancer cells.

Abstract: An approach is provided for determining an alternative route based on status information of a traffic signal and/or attributes associated with a road segment. The approach involves determining status information for the at least one traffic signal based, at least in part, on a determination that at least one vehicle is within at least one distance threshold. The approach also involves causing, at least in part, a calculation of at least one alternative route based, at least in part, on the status information for the at least one traffic signal, one or more attributes associated with at least one road segment, or a combination thereof. The approach further involves causing, at least in part, a comparison of estimated time of arrival by the use of the at least one alternative route, at least one original route, or a combination thereof to determine at least one recommended route.

Abstract: The present invention provides for a composition and a method for treating a subject afflicted with a cancer, wherein the composition comprises therapeutically effective amounts of: (a) an anti-Programmed Death-Ligand 1 (PD-L1) antibody and (b) a targeted/immunomodulatory fusion protein comprising at least one tumor targeting moiety and at least one immunomodulatory moiety that counteracts the immune tolerance of cancer cells.

Abstract: An approach is provided for determining an alternative route based on status information of a traffic signal and/or attributes associated with a road segment. The approach involves determining status information for the at least one traffic signal based, at least in part, on a determination that at least one vehicle is within at least one distance threshold. The approach also involves causing, at least in part, a calculation of at least one alternative route based, at least in part, on the status information for the at least one traffic signal, one or more attributes associated with at least one road segment, or a combination thereof. The approach further involves causing, at least in part, a comparison of estimated time of arrival by the use of the at least one alternative route, at least one original route, or a combination thereof to determine at least one recommended route.