Abstract: The MAOI hydrazide substrate is targeted by protease cleavage in cells that host cancer, viral infections, or other malignant diseases because the hydrazide substrate (R?NHNHCOR?) simulates the peptide bonds (R?NHCOR?) that are innately targeted by protease cleavage. However cleavage of the hydrazide substrate forms a hydrazine radical which bonds to the protease enzyme to provide an irreversible substrate action that shuts down cell protein biosynthesis thereafter. Such process renders the malignant host cells sterile, static, and doomed to apoptosis where a disease free replacements cell can then be provided. The MAOI hydrazide drug also provides a new antibiotic purpose by rendering cells innate to infectious organisms sterile, static, and therefore harmless.