Patents by Inventor Reuben J. Shaw

Reuben J. Shaw has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PATIENT SELECTION BIOMARKERS FOR TREATMENT WITH ULK INHIBITORS
    Publication number: 20230332243
    Abstract: Provided herein are biomarkers and method of selecting patients for treating diseases, including cancer, with ULK inhibitors using the biomarkers.
    Type: Application
    Filed: September 30, 2021
    Publication date: October 19, 2023
    Inventors: Reuben J. SHAW, Sonja N. BRUN, Lilian EICHNER
  • INHIBITORS OF ULK1/2 AND METHODS OF USING SAME
    Publication number: 20230135635
    Abstract: The present disclosure is directed to compounds, compositions, formulations and methods of use thereof in the treatment and prevention of ULK mediated diseases, including cancer.
    Type: Application
    Filed: February 12, 2021
    Publication date: May 4, 2023
    Inventors: Nicholas D.P. COSFORD, Nicole A. BAKAS, Mitchell VAMOS, Reuben J. SHAW, Allison S. LIMPERT, Sonja N. BRUN
  • MONO AND COMBINATION THERAPIES WITH ULK1/2 INHIBITORS
    Publication number: 20230130766
    Abstract: Provided herein are methods of treating diseases, including cancer, with ULK inhibitors, both as monotherapies and in combination with other therapeutic agents.
    Type: Application
    Filed: February 12, 2021
    Publication date: April 27, 2023
    Inventors: Nicholas D.P. COSFORD, Reuben J. SHAW, Nicole A. BAKAS, Allison S. LIMPERT, Sonja N. BRUN, Mitchell VAMOS
  • MACROCYCLIC ULK1/2 INHIBITORS
    Publication number: 20230099804
    Abstract: The present disclosure is directed to compounds, compositions, formulations and methods of use thereof in the treatment and prevention of ULK mediated diseases, including cancer.
    Type: Application
    Filed: February 12, 2021
    Publication date: March 30, 2023
    Inventors: Nicholas D.P. COSFORD, Nicole A. BAKAS, Reuben J. SHAW, Allison S. LIMPERT, Sonja N. BRUN
  • ULK1 inhibitors and methods using same
    Patent number: 10774092
    Abstract: In certain aspects, the invention provides a method for treating a disease or condition in a subject, the method comprising co-administering to a subject in need thereof a therapeutically effective amount of at least one ULK1-inhibiting pyrimidine, and a therapeutically effective amount of an mTOR inhibitor.
    Type: Grant
    Filed: April 19, 2019
    Date of Patent: September 15, 2020
    Assignees: SALK INSTITUTE FOR BIOLOGICAL STUDIES, SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, YALE UNIVERSITY
    Inventors: Reuben J. Shaw, Daniel F. Egan, Nicholas Cosford, Benjamin Turk, Mitchell Vamos, Dhanya Raveendra Panickar, Matthew Chun, Douglas Sheffler
  • ULK1 inhibitors and methods using same
    Patent number: 10689397
    Abstract: In certain aspects, the invention provides a method for treating a disease or condition in a subject, the method comprising co-administering to a subject in need thereof a therapeutically effective amount of at least one ULK1-inhibiting pyrimidine, and a therapeutically effective amount of an mTOR inhibitor.
    Type: Grant
    Filed: February 6, 2019
    Date of Patent: June 23, 2020
    Assignees: SALK INSTITUTE FOR BIOLOGICAL STUDIES, SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, YALE UNIVERSITY
    Inventors: Reuben J. Shaw, Daniel F. Egan, Nicholas Cosford, Benjamin Turk, Mitchell Vamos, Dhanya Raveendra Panickar, Matthew Chun, Douglas Sheffler
  • NOVEL ULK1 INHIBITORS AND METHODS USING SAME
    Publication number: 20190284207
    Abstract: In certain aspects, the invention provides a method for treating a disease or condition in a subject, the method comprising co-administering to a subject in need thereof a therapeutically effective amount of at least one ULK1-inhibiting pyrimidine, and a therapeutically effective amount of an mTOR inhibitor.
    Type: Application
    Filed: April 19, 2019
    Publication date: September 19, 2019
    Inventors: Reuben J. SHAW, Daniel F. EGAN, Nicholas COSFORD, Benjamin TURK, Mitchell VAMOS, Dhanya Raveendra PANICKAR, Matthew CHUN, Douglas SHEFFLER
  • NOVEL ULK1 INHIBITORS AND METHODS USING SAME
    Publication number: 20190248806
    Abstract: In certain aspects, the invention provides a method for treating a disease or condition in a subject, the method comprising co-administering to a subject in need thereof a therapeutically effective amount of at least one ULK1-inhibiting pyrimidine, and a therapeutically effective amount of an mTOR inhibitor.
    Type: Application
    Filed: April 19, 2019
    Publication date: August 15, 2019
    Inventors: Reuben J. SHAW, Daniel F. EGAN, Nicholas COSFORD, Benjamin TURK, Mitchell VAMOS, Dhanya Raveendra PANICKAR, Matthew CHUN, Douglas SHEFFLER
  • NOVEL ULK1 INHIBITORS AND METHODS USING SAME
    Publication number: 20190152989
    Abstract: In certain aspects, the invention provides a method for treating a disease or condition in a subject, the method comprising co-administering to a subject in need thereof a therapeutically effective amount of at least one ULK1-inhibiting pyrimidine, and a therapeutically effective amount of an mTOR inhibitor.
    Type: Application
    Filed: February 6, 2019
    Publication date: May 23, 2019
    Inventors: Reuben J. SHAW, Daniel F. EGAN, Nicholas COSFORD, Benjamin TURK, Mitchell VAMOS, Dhanya Raveendra PANICKAR, Matthew CHUN, Douglas SHEFFLER
  • ULK1 inhibitors and methods using same
    Patent number: 10266549
    Abstract: In certain aspects, the invention provides a method for treating a disease or condition in a subject, the method comprising co-administering to a subject in need thereof a therapeutically effective amount of at least one ULK1-inhibiting pyrimidine, and a therapeutically effective amount of an mTOR inhibitor.
    Type: Grant
    Filed: August 25, 2015
    Date of Patent: April 23, 2019
    Assignees: SALK INSTITUTE FOR BIOLOGICAL STUDIES, SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, YALE UNIVERSITY
    Inventors: Reuben J. Shaw, Daniel F. Egan, Nicholas Cosford, Benjamin Turk, Mitchell Vamos, Dhanya Raveendra Panickar, Matthew Chun, Douglas Sheffler
  • NOVEL ULK1 INHIBITORS AND METHODS USING SAME
    Publication number: 20170342088
    Abstract: In certain aspects, the invention provides a method for treating a disease or condition in a subject, the method comprising co-administering to a subject in need thereof a therapeutically effective amount of at least one ULK1-inhibiting pyrimidine, and a therapeutically effective amount of an mTOR inhibitor.
    Type: Application
    Filed: August 25, 2015
    Publication date: November 30, 2017
    Applicants: SALK INSTITUTE FOR BIOLOGICAL STUDIES, SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE, YALE UNIVERSITY
    Inventors: REUBEN J. SHAW, DANIEL F. EGAN, NICHOLAS COSFORD, BENJAMIN TURK, MITCHELL VAMOS, DHANYA RAVEENDRA PANICKAR, MATTHEW CHUN, DOUG SHEFFLER
  • ULK1 COMPOSITIONS, INHIBITORS, SCREENING AND METHODS OF USE
    Publication number: 20160289651
    Abstract: This disclosure relates to methods and compositions useful for the treatment of cancer and diseases and disorders associated with autophagy.
    Type: Application
    Filed: February 24, 2016
    Publication date: October 6, 2016
    Applicant: Salk Institute for Biological Studies
    Inventors: Reuben J. Shaw, Daniel F. Egan, Maria Mihaylova, David Shackelford
  • Methods for enhancing muscle performance and tone
    Patent number: 9192601
    Abstract: Provided herein are methods and compositions for improving muscle performance and increasing endurance. Agonists of AMP-activated protein kinase (AMPK) and agonists of peroxisome proliferator-activated receptor delta (PPAR?) can be used in such treatments.
    Type: Grant
    Filed: December 29, 2008
    Date of Patent: November 24, 2015
    Assignee: Salk Institute for Biological Studies
    Inventors: Ronald M. Evans, Vihang A. Narkar, Reuben J. Shaw, Michael Downes, Ruth T. Yu
  • MODULATION OF HISTONE DEACETYLASES FOR THE TREATMENT OF METABOLIC DISEASE, METHODS AND COMPOSITIONS RELATED THERETO
    Publication number: 20140314788
    Abstract: The invention relates to methods and compositions for the modulation of glucose homeostasis and/or the treatment of metabolic diseases. In some embodiments, the invention relates to methods and compositions for the modulation of histone deacetylases. such as Class IIa histone deacetylases.
    Type: Application
    Filed: April 11, 2011
    Publication date: October 23, 2014
    Applicant: Salk Institute for Biological Studies
    Inventors: Reuben J. Shaw, Maria Mihaylova, Marc R. Montminy, Kim Ravnskjaer, Biao Wang
  • METHODS FOR MODULATING CIRCADIAN RHYTHMS
    Publication number: 20120264796
    Abstract: This disclosure described the role of AMPK in circadian rhythms and methods of screening for agents that modulate such rhythms, compositions that are useful for modulating such rhythms and uses thereof.
    Type: Application
    Filed: March 22, 2010
    Publication date: October 18, 2012
    Inventors: Ronald Evans, Katja A. Lamia, Reuben J. Shaw, Luciano Ditacchio, Satchidananda Panda
  • GASTROINTESTINAL DISEASE OR DISORDER IMAGING AND TREATMENT
    Publication number: 20120189544
    Abstract: The disclosure provides methods for detection, prognosis and diagnosis of gastrointestinal polyps, cancer diseases and disorders.
    Type: Application
    Filed: June 11, 2010
    Publication date: July 26, 2012
    Applicant: SALK INSTITUTE FOR BIOLOGICAL STUDIES
    Inventors: Reuben J. Shaw, David Shackelford, Debbie Vasquez
  • METHODS FOR MODULATING METABOLIC AND CIRCADIAN RHYTHMS
    Publication number: 20120134985
    Abstract: The role of AMPK in arcadian rhythms and methods of screening for agents that modulate such rhythms are disclosed. Compositions that are useful for modulating such rhythms and uses thereof are also disclosed.
    Type: Application
    Filed: March 22, 2010
    Publication date: May 31, 2012
    Applicant: The Salk Institute for Biological Studies
    Inventors: Ronald Evans, Katja A. Lamia, Reuben J. Shaw
  • METHOD FOR TREATING CANCER BY INCREASING AMP-ACTIVATED KINASE ACTIVITY
    Publication number: 20120122991
    Abstract: The invention relates to modulation of LKB1 or AMP kinase protein activity for treating disorders including diabetes and cancer. The invention also relates to screening for agents that modulate the activity of LKB1 or AMP kinase protein, which are useful in the treatment of diabetes and cancer, as well as preparing compounds for treatment of diabetes and cancer.
    Type: Application
    Filed: January 20, 2012
    Publication date: May 17, 2012
    Applicants: Dana-Farber Cancer Institute, Inc., Beth Israel Deaconess Medical Center, Inc.
    Inventors: Lewis C. Cantley, Reuben J. Shaw, Nabeel Bardeesy, Ronald A. Depinho
  • METHODS FOR ENHANCING MUSCLE PERFORMANCE AND TONE
    Publication number: 20110112047
    Abstract: This disclosure concerns the use of agonists of AMP-activated protein kinase (AMPK) for improving exercise and modifying energy metabolism in a subject. The disclosure also relates to a combination of AMPK and peroxisome proliferator-activated receptor (PPAR) ? agonists for improving exercise performance in a subject, methods for identifying substance-enhanced exercise performance in a subject, and methods for identifying compounds that affect the interaction of PPAR? with exercise-induced kinases.
    Type: Application
    Filed: December 29, 2008
    Publication date: May 12, 2011
    Inventors: Ronald M. Evans, Vihang A. Narkar, Reuben J. Shaw, Michael Downes, Ruth T. Yu
  • Tumor Suppressor Lkb1 Kinase Directly Activates Amp-Activated Kinase
    Publication number: 20080194019
    Abstract: The invention relates to modulation of LKB1 or AMP kinase protein activity for treating disorders including diabetes and cancer. The invention also relates to screening for agents that modulate the activity of LKB1 or AMP kinase protein, which are useful in the treatment of diabetes and cancer, as well as preparing compounds for treatment of diabetes and cancer.
    Type: Application
    Filed: September 4, 2004
    Publication date: August 14, 2008
    Applicants: Beth Israel Deaconess Medical Center, Inc., Dana-Farber Cancer Institute, Inc.
    Inventors: Lewis C. Cantley, Reuben J. Shaw, Nabeel Bardeesy, Ronald A. Depinho