Patents by Inventor Reuven Tirosh
Reuven Tirosh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230228755Abstract: A method of diagnosing lung cancer in a subject-in-need thereof is provided. The method comprises: (a) providing a biological sample of the subject which comprises peripheral blood mononuclear cells (PBMCs); (b) in vitro contacting the PBMCs with a stimulant selected from the group consisting of the stimulants listed in Tables 3 and 4; and (c) measuring metabolic activity of the PBMCs having been contacted according to (b), wherein a statistically significant change in the metabolic activity of the PBMCs as compared to a control sample is indicative of lung cancer.Type: ApplicationFiled: January 27, 2023Publication date: July 20, 2023Applicants: Savicell Diagnostic Ltd., Ramot at Tel-Aviv University Ltd.Inventors: Giora DAVIDOVITS, Fernando PATOLSKY, David Eyal DAVIDOVITS, Irit ARBEL, Shoval TIRMAN, Aviv LUTATY, Tali SCIENMANN, Reuven TIROSH, Hagit PERETZ-SOROKA
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Patent number: 11619634Abstract: A method of diagnosing lung cancer in a subject-in-need thereof is provided. The method comprises: (a) providing a biological sample of the subject which comprises peripheral blood mononuclear cells (PBMCs); (b) in vitro contacting the PBMCs with a stimulant selected from the group consisting of the stimulants listed in Tables 3 and 4; and (c) measuring metabolic activity of the PBMCs having been contacted according to (b), wherein a statistically significant change in the metabolic activity of the PBMCs as compared to a control sample is indicative of lung cancer.Type: GrantFiled: August 20, 2018Date of Patent: April 4, 2023Assignees: Savicell Diagnostic Ltd., Ramot at Tel-Aviv University Ltd.Inventors: Giora Davidovits, Fernando Patolsky, David Eyal Davidovits, Irit Arbel, Shoval Tirman, Aviv Lutaty, Tali Scienmann, Reuven Tirosh, Hagit Peretz-Soroka
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Publication number: 20200355689Abstract: A method of diagnosing lung cancer in a subject-in-need thereof is provided. The method comprises: (a) providing a biological sample of the subject which comprises peripheral blood mononuclear cells (PBMCs); (b) in vitro contacting the PBMCs with a stimulant selected from the group consisting of the stimulants listed in Tables 3 and 4; and (c) measuring metabolic activity of the PBMCs having been contacted according to (b), wherein a statistically significant change in the metabolic activity of the PBMCs as compared to a control sample is indicative of lung cancer.Type: ApplicationFiled: August 20, 2018Publication date: November 12, 2020Applicants: SAVICELL DIAGNOSTIC LTD., RAMOT AT TEL-AVIV UNIVERSITY LTD.Inventors: Giora DAVIDOVITS, Fernando PATOLSKY, David Eyal DAVIDOVITIS, Irit ARBEL, Shoval TIRMAN, Aviv LUTATY, Tali SCIENMANN, Reuven TIROSH, Hagit PERETZ-SOROKA
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Patent number: 10190082Abstract: A mulitwell plate having a plurality of picowells on the bottom of the wells of the plate as well as methods of producing the mulitwell plate are provided. Provided is also a method of handling living cells by providing an ordered array of living cells immobilized in a non-fluid matrix, contacting the living cells with a stimulus; and detecting a response to the stimulus. The present invention is also of a method of producing an ordered array of living cells.Type: GrantFiled: October 15, 2015Date of Patent: January 29, 2019Assignee: Seng Enterprises Ltd.Inventors: Mordechai Deutsch, Max Herzberg, Reuven Tirosh, Assaf Deutsch
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Publication number: 20180038849Abstract: A method of measuring a metabolic activity (MA) of a cell is provided. The method comprising independently measuring in an extracellular environment of the cell, time-dependent acidification profiles due to secretion of: (i) non-volatile soluble metabolic products; (ii) non-volatile soluble metabolic products and volatile soluble metabolic products; and (iii) volatile soluble metabolic products; wherein at least one of the time dependent acidification profiles is indicative of the metabolic activity of the cell. Also provided are clinical methods which make use of the assay.Type: ApplicationFiled: October 4, 2017Publication date: February 8, 2018Applicant: Ramot at Tel-Aviv University Ltd.Inventors: Reuven TIROSH, Fernando PATOLSKY, Hagit PERETZ-SOROKA
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Patent number: 9784731Abstract: A method of measuring a metabolic activity (MA) of a cell is provided. The method comprising independently measuring in an extracellular environment of the cell, time-dependent acidification profiles due to secretion of: (i) non-volatile soluble metabolic products; (ii) non-volatile soluble metabolic products and volatile soluble metabolic products; and (iii) volatile soluble metabolic products; wherein at least one of the time dependent acidification profiles is indicative of the metabolic activity of the cell. Also provided are clinical methods which make use of the assay.Type: GrantFiled: May 18, 2014Date of Patent: October 10, 2017Assignee: Ramot at Tel-Aviv University Ltd.Inventors: Reuven Tirosh, Fernando Patolsky, Hagit Peretz-Soroka
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Publication number: 20160032230Abstract: A mulitwell plate having a plurality of picowells on the bottom of the wells of the plate as well as methods of producing the mulitwell plate are provided. Provided is also a method of handling living cells by providing an ordered array of living cells immobilized in a non-fluid matrix, contacting the living cells with a stimulus; and detecting a response to the stimulus. The present invention is also of a method of producing an ordered array of living cells.Type: ApplicationFiled: October 15, 2015Publication date: February 4, 2016Applicant: Seng Enterprises Ltd.Inventors: Mordechai DEUTSCH, Max HERZBERG, Reuven TIROSH, Assaf DEUTSCH
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Patent number: 9200245Abstract: A mulitwell plate having a plurality of picowells on the bottom of the wells of the plate as well as methods of producing the mulitwell plate are provided. Provided is also a method of handling living cells by providing an ordered array of living cells immobilized in a non-fluid matrix, contacting the living cells with a stimulus; and detecting a response to the stimulus. The present invention is also of a method of producing an ordered array of living cells.Type: GrantFiled: July 20, 2004Date of Patent: December 1, 2015Assignee: Seng Enterprises Ltd.Inventors: Mordechai Deutsch, Max Herzberg, Reuven Tirosh, Assaf Deutsch
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Publication number: 20140255972Abstract: A method of measuring a metabolic activity (MA) of a cell is provided. The method comprising independently measuring in an extracellular environment of the cell, time-dependent acidification profiles due to secretion of: (i) non-volatile soluble metabolic products; (ii) non-volatile soluble metabolic products and volatile soluble metabolic products; and (iii) volatile soluble metabolic products; wherein at least one of the time dependent acidification profiles is indicative of the metabolic activity of the cell. Also provided are clinical methods which make use of the assay.Type: ApplicationFiled: May 18, 2014Publication date: September 11, 2014Applicant: Ramot at Tel-Aviv University Ltd.Inventors: Reuven TIROSH, Fernando Patolsky, Hagit Peretz-Soroka
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Patent number: 8728758Abstract: A method of measuring a metabolic activity (MA) of a cell is provided. The method comprising independently measuring in an extracellular environment of the cell, time-dependent acidification profiles due to secretion of: (i) non-volatile soluble metabolic products; (ii) non-volatile soluble metabolic products and volatile soluble metabolic products; and (iii) volatile soluble metabolic products; wherein at least one of the time dependent acidification profiles is indicative of the metabolic activity of the cell. Also provided are clinical methods which make use of the assay.Type: GrantFiled: April 4, 2012Date of Patent: May 20, 2014Assignee: Ramot at Tel-Aviv University Ltd.Inventors: Reuven Tirosh, Fernando Patolsky, Hagit Peretz-Soroka
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Publication number: 20130224789Abstract: A method of measuring a metabolic activity (MA) of a cell is provided. The method comprising independently measuring in an extracellular environment of the cell, time-dependent acidification profiles due to secretion of: (i) non-volatile soluble metabolic products; (ii) non-volatile soluble metabolic products and volatile soluble metabolic products; and (iii) volatile soluble metabolic products; wherein at least one of the time dependent acidification profiles is indicative of the metabolic activity of the cell. Also provided are clinical methods which make use of the assay.Type: ApplicationFiled: April 4, 2012Publication date: August 29, 2013Applicant: Ramot at Tel-Aviv University Ltd.Inventors: Reuven Tirosh, Fernando Patolsky, Hagit Peretz-Soroka
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Publication number: 20070292837Abstract: A mulitwell plate having a plurality of picowells on the bottom of the wells of the plate as well as methods of producing the mulitwell plate are provided. Provided is also a method of handling living cells by providing an ordered array of living cells immobilized in a non-fluid matrix, contacting the living cells with a stimulus; and detecting a response to the stimulus. The present invention is also of a method of producing an ordered array of living cells.Type: ApplicationFiled: July 20, 2004Publication date: December 20, 2007Inventors: Mordechai Deutsch, Max Herzberg, Reuven Tirosh, Assaf Deutsch
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Publication number: 20060240548Abstract: A chip-device is provided for holding living cells in a plurality of wells disposed on the surface of a carrier, characterized in that the wells are configures to influence the proliferation of living cells in the wells, for example by changing the size of the wells, delaying or inhibiting cell-proliferation, delaying or inhibiting cell adhesion, or allowing cell proliferation inside or through components of the device itself. The influence on cell proliferation is achieved, for example, by coating the inside of the wells or fashioning the carrier from materials such as gels, especially hydrogels, polydimethylsiloxane, elastomers or polymerized para-xylylene molecules. Provided is also a gel-cover for any cell-holding device. Provided is also a method for making the devices of the present invention. Provided is also a method of manipulating cells by covering wells where the cells are held with gel or by increasing the size of wells wherein cells are held.Type: ApplicationFiled: June 27, 2004Publication date: October 26, 2006Inventors: Mordechai Deutsch, Max Herzberg, Reuven Tirosh, Assaf Deutsch