Patents by Inventor Rex Pratt

Rex Pratt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Acyl phosphonate inhibitors of ?-lactamases
    Patent number: 7205285
    Abstract: The invention provides novel ?-lactamase inhibitors, which are structurally unrelated to the natural product and semi-synthetic ?-lactamase inhibitors presently available, and which do not possess a ?-lactam pharmacophore. These new inhibitors are fully synthetic, allowing ready access to a wide variety of structurally related analogs. Certain embodiments of these new inhibitors also bind bacterial DD-peptidases, thus potentially acting both as ?-lactamase inhibitors and as antibiotics.
    Type: Grant
    Filed: July 28, 2003
    Date of Patent: April 17, 2007
    Assignee: Methylgene, Inc.
    Inventors: Jeffrey M. Besterman, Jubrail Rahil, Rex Pratt
  • Acyl phosphonate inhibitors of beta-lactamases
    Publication number: 20050119233
    Abstract: The invention provides novel ?-lactamase inhibitors, which are structurally unrelated to the natural product and semi-synthetic ?-lactamase inhibitors presently available, and which do not possess a ?-lactam pharmacophore. These new inhibitors are fully synthetic, allowing ready access to a wide variety of structurally related analogs. Certain embodiments of these new inhibitors also bind bacterial DD-peptidases, thus potentially acting both as ?-lactamase inhibitors and as antibiotics.
    Type: Application
    Filed: July 28, 2003
    Publication date: June 2, 2005
    Inventors: Jeffrey Besterman, Jubrail Rahil, Rex Pratt
  • &bgr;-lactamase and DD-peptidase inhibitors
    Patent number: 6608046
    Abstract: The invention provides novel &bgr;-lactamase inhibitors, which are structurally unrelated to the natural product and semi-synthetic &bgr;-lactamase inhibitors presently available, and which do not possess &bgr;-lactam pharmacophore. These new inhibitors are fully synthetic, allowing ready access to a wide variety of structurally related analogs. Certain embodiments of these new inhibitors also bind bacterial DD-peptidases, thus potentially acting both as &bgr;-lactamase inhibitors and as antibiotics.
    Type: Grant
    Filed: September 1, 2000
    Date of Patent: August 19, 2003
    Assignee: MethylGene, Inc.
    Inventors: Jeffrey M. Besterman, Jubrail Rahil, Rex Pratt
  • Acyl phosphonate inhibitors of &bgr;-lactamases
    Patent number: 6599889
    Abstract: The invention provides novel &bgr;-lactamase inhibitors, which are structurally unrelated to the natural product and semi-synthetic &bgr;-lactamase inhibitors presently available, and which do not possess a &bgr;-lactam pharmacophore. These new inhibitors are fully synthetic, allowing ready access to a wide variety of structurally related analogs. Certain embodiments of these new inhibitors also bind bacterial DD-peptidases, thus potentially acting both as &bgr;-lactamase inhibitors and as antibiotics.
    Type: Grant
    Filed: March 1, 2001
    Date of Patent: July 29, 2003
    Assignee: MethylGere, Inc.
    Inventors: Jeffrey M. Besterman, Jubrail Rahil, Rex Pratt
  • Acyl phosphonate inhibitors of beta-lactamases
    Publication number: 20020022607
    Abstract: The invention provides novel &bgr;-lactamase inhibitors, which are structurally unrelated to the natural product and semi-synthetic &bgr;-lactamase inhibitors presently available, and which do not possess a &bgr;-lactam pharmacophore. These new inhibitors are fully synthetic, allowing ready access to a wide variety of structurally related analogs. Certain embodiments of these new inhibitors also bind bacterial DD-peptidases, thus potentially acting both as &bgr;-lactamase inhibitors and as antibiotics.
    Type: Application
    Filed: March 1, 2001
    Publication date: February 21, 2002
    Inventors: Jeffrey M. Besterman, Jubrail Rahil, Rex Pratt
  • 6.beta.-Bromo penicillanic acid
    Patent number: 4180506
    Abstract: 6.beta.-Bromo penicillanic acid is a novel compound which is an antibacterial agent as well as a potent .beta.-lactamase inhibitor.
    Type: Grant
    Filed: January 18, 1978
    Date of Patent: December 25, 1979
    Inventor: Rex Pratt