Patents by Inventor Rex T. Gallagher
Rex T. Gallagher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 9926287Abstract: A method of crystallizing docetaxel is disclosed. The method comprises (a) combining docetaxel and at least one solubilizing solvent to obtain a solution, wherein the solubilizing solvent is selected from the group consisting of acetone, methyl-tert-butyl ether, tetrahydrofuran (THF), and acetonitrile and (b) adding an anti-solvent to the solution to obtain a crystalline docetaxel, wherein the anti-solvent is water.Type: GrantFiled: November 18, 2016Date of Patent: March 27, 2018Assignee: Phyton Holdings, LLCInventors: Brian A. Bucher, Edward M. Desimone, III, Roland R. Franke, Rex T. Gallagher, Barry J. Hand, Christopher D. Howe, James H. Johnson, John S. Juchum, Marc A. Plante, T.G. Sambandam, Dong S. Yang
-
Publication number: 20170066734Abstract: A method of crystallizing docetaxel is disclosed. The method comprises (a) combining docetaxel and at least one solubilizing solvent to obtain a solution, wherein the solubilizing solvent is selected from the group consisting of acetone, methyl-tert-butyl ether, tetrahydrofuran (THF), and acetonitrile and (b) adding an anti-solvent to the solution to obtain a crystalline docetaxel, wherein the anti-solvent is water.Type: ApplicationFiled: November 18, 2016Publication date: March 9, 2017Inventors: Brian A. Bucher, Edward M. Desimone, III, Roland R. Franke, Rex T. Gallagher, Barry J. Hand, Christopher D. Howe, James H. Johnson, John S. Juchum, Marc A. Plante, T.G. Sambandam, Dong S. Yang
-
Patent number: 9527825Abstract: Disclosed is a method of crystallizing docetaxel comprising combining docetaxel and at least one solubilizing solvent to obtain a solution, wherein the solubilizing solvent is methylene chloride and adding an anti-solvent to the solution to obtain a crystalline docetaxel, wherein the anti-solvent is water.Type: GrantFiled: February 25, 2016Date of Patent: December 27, 2016Assignee: Phyton Holdings, LLCInventors: Brian A. Bucher, Edward M. Desimone, III, Roland R. Franke, Rex T. Gallagher, Barry J. Hand, Christopher D. Howe, James H. Johnson, John S. Juchum, Marc A. Plante, T. G. Sambandam, Dong S. Yang
-
Publication number: 20160176837Abstract: Disclosed is a method of crystallizing docetaxel comprising combining docetaxel and at least one solubilizing solvent to obtain a solution, wherein the solubilizing solvent is methylene chloride and adding an anti-solvent to the solution to obtain a crystalline docetaxel, wherein the anti-solvent is water.Type: ApplicationFiled: February 25, 2016Publication date: June 23, 2016Inventors: Brian A. Bucher, Edward M. Desimone, III, Roland R. Franke, Rex T. Gallagher, Barry J. Hand, Christopher D. Howe, James H. Johnson, John S. Juchum, Marc A. Plante, T.G. Sambandam, Dong S. Yang
-
Patent number: 9303004Abstract: Disclosed is a method of crystallizing a taxane comprising combining the taxane and methylene chloride to obtain a solution and adding an anti-solvent to the solution to obtain a crystalline taxane, wherein the anti-solvent is selected from the group consisting of hexane and heptane.Type: GrantFiled: February 24, 2014Date of Patent: April 5, 2016Assignee: Phyton Holdings, LLCInventors: James H. Johnson, T. G. Sambandam, Barry J. Hand, Christopher D. Howe, Roland R. Franke, Brian A. Bucher, John S. Juchum, Rex T. Gallagher, Marc A. Plante, Edward M. Desimone, III, Dong S. Yang
-
Publication number: 20150005517Abstract: Disclosed is a method of crystallizing a taxane comprising combining the taxane and methylene chloride to obtain a solution and adding an anti-solvent to the solution to obtain a crystalline taxane, wherein the anti-solvent is selected from the group consisting of hexane and heptane.Type: ApplicationFiled: February 24, 2014Publication date: January 1, 2015Applicant: Phyton Holdings LLCInventors: James H. Johnson, T.G. Sambandam, Barry J. Hand, Christopher D. Howe, Roland R. Franke, Brian A. Bucher, John S. Juchum, Rex T. Gallagher, Marc A. Plante, Edward M. Desimone, III, Dong S. Yang
-
Patent number: 8703982Abstract: Disclosed is a method of crystallizing a taxane comprising combining the taxane and methylene chloride to obtain a solution and adding an anti-solvent to the solution to obtain a crystalline taxane, wherein the anti-solvent is selected from the group consisting of hexane and heptane.Type: GrantFiled: February 12, 2010Date of Patent: April 22, 2014Assignee: Phyton Holdings LLCInventors: Brian A. Bucher, Edward M. Desimone, III, Roland R. Franke, Rex T. Gallagher, Barry J. Hand, Christopher D. Howe, James A. Johnson, John S. Juchum, Marc A. Plante, T. G. Sambandam, Dong S. Yang
-
Patent number: 7897796Abstract: This invention is directed to a method for isolating and/or purifying one or more taxanes from materials comprising taxanes. In one embodiment, the method comprises the steps of: (a) treating a taxane containing material with an amino containing material attached to a solid matrix, such as a polyethyleneimine-bonded silica chromatographic resin; (b) eluting the desired taxane compound from the resin; and (c) recovering the eluted taxane compound.Type: GrantFiled: June 18, 2007Date of Patent: March 1, 2011Assignee: Phyton Holdings, LLCInventors: James H. Johnson, T. G. Sambandam, Barry J. Hand, Christopher D. Howe, Roland R. Franke, Brian A. Bucher, John S. Juchum, Rex T. Gallagher, Marc A. Plante, Edward M. Desimone, III, Dong S. Yang
-
Publication number: 20100145080Abstract: Disclosed is a method of crystallizing a taxane comprising combining the taxane and methylene chloride to obtain a solution and adding an anti-solvent to the solution to obtain a crystalline taxane, wherein the anti-solvent is selected from the group consisting of hexane and heptane.Type: ApplicationFiled: February 12, 2010Publication date: June 10, 2010Applicant: Phyton Holdings LLCInventors: James H. Johnson, T.G. Sambandam, Barry J. Hand, Christopher D. Howe, Roland R. Franke, Brian A. Bucher, John S. Juchum, Rex T. Gallagher, Marc A. Plante, Edward M. Desimone, III, Dong S. Yang
-
Patent number: 7605278Abstract: The invention relates to methods and compositions for converting taxane amides to paclitaxel or other taxanes. In one alternative embodiment, the present invention comprises; (i) selectively protecting at least one OH group of a taxane amide; (ii) contacting the taxane amide with a transition metal compound to reduce the amide; (iii) contacting the reduced amide with an agent capable of substantially removing the transition metal; (iv) contacting the reduced amide with a hydrolyzing amount of acid to form a taxane amine salt in solution; (v) adding a sufficient amount of solvent to solidify the amine salt; and (vi) converting the taxane amine salt into paclitaxel or other taxanes.Type: GrantFiled: August 4, 2003Date of Patent: October 20, 2009Assignee: Natural Pharmaceuticals, Inc.Inventors: Dasheng Wang, Rex T. Gallagher, John S. Juchum, James H. Johnson
-
Publication number: 20080051589Abstract: The invention relates to methods and compositions for converting taxane amides to paclitaxel or other taxanes. In one alternative embodiment, the present invention comprises; (i) selectively protecting at least one OH group of a taxane amide; (ii) contacting the taxane amide with a transition metal compound to reduce the amide; (iii) contacting the reduced amide with an agent capable of substantially removing the transition metal; (iv) contacting the reduced amide with a hydrolyzing amount of acid to form a taxane amine salt in solution; (v) adding a sufficient amount of solvent to solidify the amine salt; and (vi) converting the taxane amine salt into paclitaxel or other taxanes.Type: ApplicationFiled: August 4, 2003Publication date: February 28, 2008Applicant: NATURAL PHARMACEUTICALS, INC.Inventors: Dasheng Wang, Rex T. Gallagher, John S. Juchum, James H. Johnson
-
Patent number: 7220872Abstract: The invention provides methods and compositions for reductively deoxygenating an amide group at a C-3? position of a taxane molecule followed by subsequent intra-molecular acyl migration of an acyl group to the C-3? position.Type: GrantFiled: April 5, 2003Date of Patent: May 22, 2007Assignee: Natural Pharmaceuticals, Inc.Inventors: James H. Johnson, Rex T. Gallagher, Roland R. Franke
-
Patent number: 7176325Abstract: The invention provides methods and compositions for selectively acylating a specific hydroxyl group in a molecule of interest containing at least two unprotected secondary hydroxyl groups. Although the methods and compositions of the invention have general applicability, they are particularly useful in the selective acylation of taxane molecules.Type: GrantFiled: April 5, 2003Date of Patent: February 13, 2007Assignee: Natural Pharmaceuticals, Inc.Inventors: James H. Johnson, Richard J. Pariza, Rex T. Gallagher
-
Patent number: 6998470Abstract: The present invention relates to a method of isolating and/or purifying hypothalamic inhibitory factor (HIF) from a sample (e.g., tissue fluid) containing HIF. The present invention provides for isolation of large amounts of HIF using diafiltration, solid phase extraction and immunoaffinity techniques. In one embodiment, the invention relates to a method of purifying hypothalamic inhibitory factor from a sample containing hypothalamic inhibitory factor comprising subjecting the sample to diafiltration, solid phase extraction and immunoaffintiy chromatography.Type: GrantFiled: February 17, 2000Date of Patent: February 14, 2006Assignees: Bion, Inc., The General Hospital Corp.Inventors: Rex T. Gallagher, Garner T. Haupert, Jr.
-
Patent number: 6956123Abstract: This invention is directed to a method for isolating and/or purifying one or more taxanes from materials comprising taxanes. In one embodiment, the method comprises the steps of: (a) treating a taxane containing material with an amino containing material attached to a solid matrix, such as a polyethyleneimine-bonded silica chromatographic resin; (b) eluting the desired taxane compound from the resin; and (c) recovering the eluted taxane compound.Type: GrantFiled: September 18, 2003Date of Patent: October 18, 2005Assignee: Natural Pharmaccuticals, Inc.Inventors: James H. Johnson, T. G. Sambandan, Barry J. Haad, Christopher D. Howe, Roland R. Franke, Brian A. Bucher, John S. Juchum, Rex T. Gallagher, Marc A. Plant, Edward M. De Simone, III, Dong S. Yang
-
Publication number: 20040186305Abstract: This invention is directed to a method for isolating and/or purifying one or more taxanes from materials comprising taxanes. In one embodiment, the method comprises the steps of: (a) treating a taxane containing material with an amino containing material attached to a solid matrix, such as a polyethyleneimine-bonded silica chromatographic resin; (b) eluting the desired taxane compound from the resin; and (c) recovering the eluted taxane compound.Type: ApplicationFiled: September 18, 2003Publication date: September 23, 2004Inventors: James H. Johnson, T.G. Sambandan, Barry J. Hand, Christopher D. Howe, Roland R. Franke, Brian A. Bucher, John S. Jucham, Rex T. Gallagher, Marc A. Plant, Edward M. De Simone, Dong S. Yang
-
Patent number: 6359000Abstract: A method of treating cancer with a pharmaceutical composition containing a pine root (Deutero Mycetes) fungal metabolite or an analog or derivative thereof.Type: GrantFiled: July 12, 1999Date of Patent: March 19, 2002Assignee: Millennium Pharmaceuticals, Inc.Inventors: Wei-Dong Jiang, Zhi-Dong Jiang, Rex T. Gallagher
-
Patent number: 5932613Abstract: A method of treating cancer with a pharmaceutical composition containing a pine root (Deutero Mycetes) fungal metabolite or an analog or derivative thereof.Type: GrantFiled: July 3, 1996Date of Patent: August 3, 1999Assignee: Millennium Pharmaceuticals, Inc.Inventors: Wei-Dong Jiang, Zhi-Dong Jiang, Rex T. Gallagher
-
Patent number: 5837726Abstract: A natural product of Aspergillus fumigatus and specific derivatives thereof, and a method of treating fungal infection therewith.Type: GrantFiled: November 1, 1995Date of Patent: November 17, 1998Assignee: Millennium Pharmaceuticals, Inc.Inventors: David Qin Liu, Zhi-Dong Jiang, Rex T. Gallagher, T. Vance Morgan