Patents by Inventor Reynald VANDERSTRAETEN
Reynald VANDERSTRAETEN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240075314Abstract: A computing system comprising a central processing unit (CPU), and memory coupled to the CPU and having stored therein instructions that, when executed by the computing system, cause the computing system to execute operations to generate a radiation treatment plan. The operations include accessing a minimum prescribed dose to be delivered into and across the target, determining a number of beams and directions of the beams, and determining a beam energy for each of the beams, wherein the number of beams, the directions of the beams, and the beam energy for each of the beams are determined such that the entire target receives the minimum prescribed dose. The operations further include prescribing a dose rate and optimizing dose rate constraints for FLASH therapy, and displaying a dose rate map of the FLASH therapy.Type: ApplicationFiled: November 1, 2023Publication date: March 7, 2024Applicants: Varian Medical Systems, Inc., Siemens Healthineers International AG, Varian Medical Systems Particle Therapy GmbHInventors: Christel SMITH, Timo KOPONEN, Reynald VANDERSTRAETEN, Anthony MAGLIARI, Eric ABEL, Jessica PEREZ, Michael FOLKERTS, Deepak KHUNTIA
-
Patent number: 11865364Abstract: A computing system comprising a central processing unit (CPU), and memory coupled to the CPU and having stored therein instructions that, when executed by the computing system, cause the computing system to execute operations to generate a radiation treatment plan. The operations include accessing a minimum prescribed dose to be delivered into and across the target, determining a number of beams and directions of the beams, and determining a beam energy for each of the beams, wherein the number of beams, the directions of the beams, and the beam energy for each of the beams are determined such that the entire target receives the minimum prescribed dose. The operations further include prescribing a dose rate and optimizing dose rate constraints for FLASH therapy, and displaying a dose rate map of the FLASH therapy.Type: GrantFiled: December 22, 2022Date of Patent: January 9, 2024Assignees: Varian Medical Systems, Inc., Varian Medical Systems Particle Therapy GmbH, Siemens Healthineers International AGInventors: Christel Smith, Timo Koponen, Reynald Vanderstraeten, Anthony Magliari, Eric Abel, Jessica Perez, Michael Folkerts, Deepak Khuntia
-
Patent number: 11865361Abstract: Embodiments of the present invention provide methods and systems for proton therapy planning that maximize the dose rate for different target sizes for FLASH therapy treatment are disclosed herein according to embodiments of the present invention. According to embodiments, non-standard scanning patterns can be generated, for example, using a TPS optimizer, to maximize dose rate and the overall FLASH effect for specific volumes at risk. The novel scanning patterns can include scanning subfields of a field that are scanned independently or spiral-shaped patterns, for example. In general, spot locations and beam paths between spots are optimized to substantially achieve a desired dose rate in defined regions of the patient's body for FLASH therapy treatment.Type: GrantFiled: April 3, 2020Date of Patent: January 9, 2024Assignees: VARIAN MEDICAL SYSTEMS, INC., VARIAN MEDICAL SYSTEMS PARTICLE THERAPY GMBH & CO. KG, SIEMENS HEALTHINEERS INTERNATIONAL AGInventors: Jessica Perez, Eric Abel, Michael Folkerts, Christel Smith, Adam Harrington, Timo Koponen, Reynald Vanderstraeten, Anthony Magliari, Michiko Rossi
-
Publication number: 20230271030Abstract: Radiation treatment planning includes accessing values of parameters such as a number of beams to be directed into sub-volumes in a target, beam directions, and beam energies. Information that specifies limits for the radiation treatment plan are accessed. The limits include a limit on irradiation time for each sub-volume outside the target. Other limits can include a limit on irradiation time for each sub-volume in the target, a limit on dose rate for each sub volume in the target, and a limit on dose rate for each sub-volume outside the target. The values of the parameters are adjusted until the irradiation time for each sub-volume outside the target satisfies the maximum limit on irradiation time.Type: ApplicationFiled: May 5, 2023Publication date: August 31, 2023Applicants: Varian Medical Systems, Inc., Siemens Healthineers International AGInventors: Reynald VANDERSTRAETEN VANDERSTRAETEN, Eric ABEL, Christel SMITH, Anthony MAGLIARI, Timo KOPONEN, Stanley MANSFIELD, Charles ADELSHEIM
-
Publication number: 20230211178Abstract: A computing system comprising a central processing unit (CPU), and memory coupled to the CPU and having stored therein instructions that, when executed by the computing system, cause the computing system to execute operations to generate a radiation treatment plan. The operations include accessing a minimum prescribed dose to be delivered into and across the target, determining a number of beams and directions of the beams, and determining a beam energy for each of the beams, wherein the number of beams, the directions of the beams, and the beam energy for each of the beams are determined such that the entire target receives the minimum prescribed dose. The operations further include prescribing a dose rate and optimizing dose rate constraints for FLASH therapy, and displaying a dose rate map of the FLASH therapy.Type: ApplicationFiled: December 22, 2022Publication date: July 6, 2023Inventors: Christel SMITH, Timo KOPONEN, Reynald VANDERSTRAETEN, Anthony MAGLIARI, Eric ABEL, Jessica PEREZ, Michael FOLKERTS, Deepak KHUNTIA
-
Publication number: 20230191154Abstract: A system for treating a patient during radiation therapy is disclosed. The system includes a shell, a plurality of material inserts disposed in the shell, where each material insert of the plurality of material inserts respectively shapes a distribution of a dose delivered to the patient by a respective beam of a plurality of beams emitted from a nozzle of a radiation treatment system, and a scaffold component disposed in the shell that holds the plurality material inserts in place relative to the patient such that each material insert lies on a path of at least one of the beams.Type: ApplicationFiled: February 14, 2023Publication date: June 22, 2023Inventors: Eric ABEL, Corey ZANKOWSKI, Jessica PEREZ, Anthony MAGLIARI, Christel SMITH, MIchael FOLKERTS, Bill HANSEN, Reynald VANDERSTRAETEN, Timo KOPONEN
-
Patent number: 11673003Abstract: Radiation treatment planning includes accessing values of parameters such as a number of beams to be directed into sub-volumes in a target, beam directions, and beam energies. Information that specifies limits for the radiation treatment plan are accessed. The limits include a limit on irradiation time for each sub-volume outside the target. Other limits can include a limit on irradiation time for each sub-volume in the target, a limit on dose rate for each sub-volume in the target, and a limit on dose rate for each sub-volume outside the target. The values of the parameters are adjusted until the irradiation time for each sub-volume outside the target satisfies the maximum limit on irradiation time.Type: GrantFiled: November 6, 2020Date of Patent: June 13, 2023Assignees: VARIAN MEDICAL SYSTEMS, INC., VARIAN MEDICAL SYSTEMS INTERNATIONAL AGInventors: Reynald Vanderstraeten, Eric Abel, Christel Smith, Anthony Magliari, Timo Koponen, Stanley Mansfield, Charles Adelsheim
-
Patent number: 11590364Abstract: A system for treating a patient during radiation therapy is disclosed. The system includes a shell, a plurality of material inserts disposed in the shell, where each material insert of the plurality of material inserts respectively shapes a distribution of a dose delivered to the patient by a respective beam of a plurality of beams emitted from a nozzle of a radiation treatment system, and a scaffold component disposed in the shell that holds the plurality material inserts in place relative to the patient such that each material insert lies on a path of at least one of the beams.Type: GrantFiled: June 10, 2019Date of Patent: February 28, 2023Assignees: Varian Medical Systems International AG, Varian Medical Systems Particle Therapy GmbH & Co. KG, Varian Medical Systems, Inc.Inventors: Eric Abel, Corey Zankowski, Jessica Perez, Anthony Magliari, Christel Smith, Michael Folkerts, Bill Hansen, Reynald Vanderstraeten, Timo Koponen
-
Patent number: 11554271Abstract: A computing system comprising a central processing unit (CPU), and memory coupled to the CPU and having stored therein instructions that, when executed by the computing system, cause the computing system to execute operations to generate a radiation treatment plan. The operations include accessing a minimum prescribed dose to be delivered into and across the target, determining a number of beams and directions of the beams, and determining a beam energy for each of the beams, wherein the number of beams, the directions of the beams, and the beam energy for each of the beams are determined such that the entire target receives the minimum prescribed dose. The operations further include prescribing a dose rate and optimizing dose rate constraints for FLASH therapy, and displaying a dose rate map of the FLASH therapy.Type: GrantFiled: January 12, 2021Date of Patent: January 17, 2023Assignees: Varian Medical Systems, Inc, Varian Medical Systems Particle Therapy GMBH & Co. KG, Varian Medical Systems International AGInventors: Christel Smith, Timo Koponen, Reynald Vanderstraeten, Anthony Magliari, Eric Abel, Jessica Perez, Michael Folkerts, Deepak Khuntia
-
Publication number: 20230001233Abstract: Presented systems and methods enable efficient and effective robust radiation treatment planning and treatment, including analysis of dose rate robustness. In one embodiment, a method comprising accessing treatment plan information, accessing information corresponding to an uncertainty associated with implementation of the radiation treatment plan, and generating a histogram, wherein the histogram conveys a characteristic of the treatment plan including an impact of the uncertainty on the characteristic. The histogram can be a dose rate volume histogram and can be utilized to test a degree of robustness of a treatment plan (e.g., including allowance for uncertainty scenarios, etc.). The uncertainty can be associated with potential variation associated with tolerances (e.g., radiation system/machine performance tolerance, patient characteristic tolerances, etc.) and set up issues (e.g., variation in initial system/machine set up, variation patient setup/position, etc.Type: ApplicationFiled: June 30, 2021Publication date: January 5, 2023Inventors: Tina PFEILER, Reynald VANDERSTRAETEN, Michiko ROSSI, Isabel HUTH, Viljo PETAJA
-
Publication number: 20210346719Abstract: A computing system comprising a central processing unit (CPU), and memory coupled to the CPU and having stored therein instructions that, when executed by the computing system, cause the computing system to execute operations to generate a radiation treatment plan. The operations include accessing a minimum prescribed dose to be delivered into and across the target, determining a number of beams and directions of the beams, and determining a beam energy for each of the beams, wherein the number of beams, the directions of the beams, and the beam energy for each of the beams are determined such that the entire target receives the minimum prescribed dose. A quantitative time-dependent model-based charged particle pencil beam scanning optimization is then implemented for FLASH therapy.Type: ApplicationFiled: July 22, 2021Publication date: November 11, 2021Inventors: Michael Matthew FOLKERTS, Jessica PEREZ, Christel SMITH, Eric ABEL, Anthony MAGLIARI, Reynald VANDERSTRAETEN, Timo Kalevi KOPONEN, Renate PARRY, Alexander KATSIS, Rajiv DUA, Michiko ALCANZARE, Perttu NIEMELA, Matti ROPO
-
Patent number: 11154726Abstract: A computer implemented method of determining a resultant treatment plan for a proton radiation therapy system based on given dose volume constraints, wherein the resultant treatment plan is optimized for treatment time comprises accessing the dose volume constraints and range information, wherein the range information indicates acceptable deviations from the dose volume constraints. Based on the proton radiation therapy system, the method further comprises accessing machine configuration information comprising a plurality of machine parameters that define a maximum resolution achievable in irradiating a patient. Further, the method comprises iteratively adjusting the plurality of machine parameters to values which decrease the maximum resolution and simulating a plurality of candidate treatment plans to generate a plurality of treatment plan results, wherein each treatment plan result comprises: a respective treatment time and a respective plan quality.Type: GrantFiled: August 10, 2020Date of Patent: October 26, 2021Assignees: Varian Medical Systems, Inc., Varian Medical Systesm Particle Therapy GmbH & Co. KG, Varian Medical Systems International AGInventors: Isabel Huth, Christel Smith, Timo Koponen, Perttu Niemela, Markus Bach, Reynald Vanderstraeten
-
Publication number: 20210308486Abstract: Embodiments of the present invention provide methods and systems for proton therapy planning that maximize the dose rate for different target sizes for FLASH therapy treatment are disclosed herein according to embodiments of the present invention. According to embodiments, non-standard scanning patterns can be generated, for example, using a TPS optimizer, to maximize dose rate and the overall FLASH effect for specific volumes at risk. The novel scanning patterns can include scanning subfields of a field that are scanned independently or spiral-shaped patterns, for example. In general, spot locations and beam paths between spots are optimized to substantially achieve a desired dose rate in defined regions of the patient's body for FLASH therapy treatment.Type: ApplicationFiled: April 3, 2020Publication date: October 7, 2021Inventors: Jessica PEREZ, Eric ABEL, Michael FOLKERTS, Christel SMITH, Adam Harrington, Timo KOPONEN, Reynald VANDERSTRAETEN, Anthony MAGLIARI, Michiko ALCANZARE
-
Patent number: 11103727Abstract: A computing system comprising a central processing unit (CPU), and memory coupled to the CPU and having stored therein instructions that, when executed by the computing system, cause the computing system to execute operations to generate a radiation treatment plan. The operations include accessing a minimum prescribed dose to be delivered into and across the target, determining a number of beams and directions of the beams, and determining a beam energy for each of the beams, wherein the number of beams, the directions of the beams, and the beam energy for each of the beams are determined such that the entire target receives the minimum prescribed dose. A quantitative time-dependent model-based charged particle pencil beam scanning optimization is then implemented for FLASH therapy.Type: GrantFiled: June 11, 2019Date of Patent: August 31, 2021Assignees: Varian Medical Systems International AG, Varian Medical Systems Particle Therapy GmbH, Varian Medical Systems, Inc.Inventors: Michael Matthew Folkerts, Jessica Perez, Christel Smith, Eric Abel, Anthony Magliari, Reynald Vanderstraeten, Timo Kalevi Koponen, Renate Parry, Alexander Katsis, Rajiv Dua, Michiko Alcanzare, Perttu Niemela, Matti Ropo
-
Patent number: 11090508Abstract: Embodiments of the present invention provide an integrated solution to radiotherapy treatment planning that enables accurate recording and accumulation of physical parameters as input (e.g., dose, dose rate, irradiation time per voxel, etc.). User-defined functions are evaluated to correlate the input parameters with 4D biological outcomes. The resulting biological parameters can be visualized as a biological outcome map to evaluate decisions, support decisions, and optimize decisions regarding the parameters of the radiotherapy treatment plan, for example, for supporting clinical trials and related clinical research.Type: GrantFiled: March 8, 2019Date of Patent: August 17, 2021Assignees: Varian medical Systems Particle Therapy GmbH & Co. KG, Varian Medical Systems International AG, Varian Medical Systems, Inc.Inventors: Michael Matthew Folkerts, Jessica Perez, Christel Smith, Eric Abel, Anthony Magliari, Reynald Vanderstraeten, Timo Kalevi Koponen, Renate Parry, Alexander Katsis, Rajiv Dua, Michiko Alcanzare, Perttu Niemela, Matti Ropo
-
Publication number: 20210128946Abstract: A computing system comprising a central processing unit (CPU), and memory coupled to the CPU and having stored therein instructions that, when executed by the computing system, cause the computing system to execute operations to generate a radiation treatment plan. The operations include accessing a minimum prescribed dose to be delivered into and across the target, determining a number of beams and directions of the beams, and determining a beam energy for each of the beams, wherein the number of beams, the directions of the beams, and the beam energy for each of the beams are determined such that the entire target receives the minimum prescribed dose. The operations further include prescribing a dose rate and optimizing dose rate constraints for FLASH therapy, and displaying a dose rate map of the FLASH therapy.Type: ApplicationFiled: January 12, 2021Publication date: May 6, 2021Inventors: Christel SMITH, Timo KOPONEN, Reynald VANDERSTRAETEN, Anthony MAGLIARI, Eric ABEL, Jessica PEREZ, Michael FOLKERTS, Deepak KHUNTIA
-
Publication number: 20210052917Abstract: Radiation treatment planning includes accessing values of parameters such as a number of beams to be directed into sub-volumes in a target, beam directions, and beam energies. Information that specifies limits for the radiation treatment plan are accessed. The limits include a limit on irradiation time for each sub-volume outside the target. Other limits can include a limit on irradiation time for each sub-volume in the target, a limit on dose rate for each sub-volume in the target, and a limit on dose rate for each sub-volume outside the target. The values of the parameters are adjusted until the irradiation time for each sub-volume outside the target satisfies the maximum limit on irradiation time.Type: ApplicationFiled: November 6, 2020Publication date: February 25, 2021Inventors: Reynald VANDERSTRAETEN, Eric ABEL, Christel SMITH, Anthony MAGLIARI, Timo KOPONEN, Stanley MANSFIELD, Charles ADELSHEIM
-
Patent number: 10918886Abstract: A computing system comprising a central processing unit (CPU), and memory coupled to the CPU and having stored therein instructions that, when executed by the computing system, cause the computing system to execute operations to generate a radiation treatment plan. The operations include accessing a minimum prescribed dose to be delivered into and across the target, determining a number of beams and directions of the beams, and determining a beam energy for each of the beams, wherein the number of beams, the directions of the beams, and the beam energy for each of the beams are determined such that the entire target receives the minimum prescribed dose. The operations further include prescribing a dose rate and optimizing dose rate constraints for FLASH therapy, and displaying a dose rate map of the FLASH therapy.Type: GrantFiled: June 10, 2019Date of Patent: February 16, 2021Assignees: Varian Medical Systems, Inc., Varian Medical Systems International AG, Varian Medical Systems Particle Therapy GMBHInventors: Christel Smith, Timo Koponen, Reynald Vanderstraeten, Anthony Magliari, Eric Abel, Jessica Perez, Michael Folkerts, Deepak Khuntia
-
Publication number: 20200406060Abstract: A computer implemented method of determining a resultant treatment plan for a proton radiation therapy system based on given dose volume constraints, wherein the resultant treatment plan is optimized for treatment time comprises accessing the dose volume constraints and range information, wherein the range information indicates acceptable deviations from the dose volume constraints. Based on the proton radiation therapy system, the method further comprises accessing machine configuration information comprising a plurality of machine parameters that define a maximum resolution achievable in irradiating a patient. Further, the method comprises iteratively adjusting the plurality of machine parameters to values which decrease the maximum resolution and simulating a plurality of candidate treatment plans to generate a plurality of treatment plan results, wherein each treatment plan result comprises: a respective treatment time and a respective plan quality.Type: ApplicationFiled: August 10, 2020Publication date: December 31, 2020Inventors: Isabel HUTH, Christel SMITH, Timo KOPONEN, Perttu NIEMELA, Markus BACH, Reynald VANDERSTRAETEN
-
Publication number: 20200384289Abstract: A computing system comprising a central processing unit (CPU), and memory coupled to the CPU and having stored therein instructions that, when executed by the computing system, cause the computing system to execute operations to generate a radiation treatment plan. The operations include accessing a minimum prescribed dose to be delivered into and across the target, determining a number of beams and directions of the beams, and determining a beam energy for each of the beams, wherein the number of beams, the directions of the beams, and the beam energy for each of the beams are determined such that the entire target receives the minimum prescribed dose. The operations further include prescribing a dose rate and optimizing dose rate constraints for FLASH therapy, and displaying a dose rate map of the FLASH therapy.Type: ApplicationFiled: June 10, 2019Publication date: December 10, 2020Inventors: Christel SMITH, Timo KOPONEN, Reynald VANDERSTRAETEN, Anthony MAGLIARI, Eric ABEL, Jessica PEREZ, Michael FOLKERTS, Deepak KHUNTIA