Patents by Inventor Reza Dana

Reza Dana has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190151404
    Abstract: Described herein are materials and methods of treating dry eye disease in a subject.
    Type: Application
    Filed: November 29, 2018
    Publication date: May 23, 2019
    Inventors: Reza Dana, Sunil Chauhan
  • Publication number: 20190046603
    Abstract: Described herein are materials and methods for treating dry eye disease in a subject.
    Type: Application
    Filed: May 23, 2018
    Publication date: February 14, 2019
    Inventors: Reza Dana, Sunil Chauhan
  • Publication number: 20190021586
    Abstract: The technology described in this document can be embodied in systems and computer-implemented methods for determining a score representing an amount of staining of the cornea. The methods include obtaining a digital image of the cornea stained with a tracer material, receiving a selection of a portion of the image, and processing, by a processing device, the selection to exclude areas with one or more artifacts to define an evaluation area. For each of a plurality of pixels within the evaluation area, a plurality of Cartesian color components are determined and a hue value in a polar coordinate based color space is calculated from the components. An amount of staining of the cornea is then determined as a function of the hue value. The methods also include assigning a score to the evaluation area based on the amount of staining calculated for the plurality of pixels.
    Type: Application
    Filed: June 25, 2018
    Publication date: January 24, 2019
    Inventors: Reza Dana, Francisco L. Amparo Pulido, Haobing Wang
  • Publication number: 20190022280
    Abstract: The present invention provides compositions and methods for repair and reconstruction of defects and injuries to the cornea.
    Type: Application
    Filed: February 8, 2017
    Publication date: January 24, 2019
    Applicants: The Brigham and Women's Hospital, Inc., Massachusetts Eye and Ear Infirmary
    Inventors: Ali KHADEMHOSSEINI, Nasim ANNABI, Reza DANA, Ahmad KHEIRKHAH
  • Patent number: 10179160
    Abstract: Described herein are materials and methods of treating dry eye disease in a subject.
    Type: Grant
    Filed: March 29, 2016
    Date of Patent: January 15, 2019
    Assignee: SCHEPENS EYE RESEARCH INSTITUTE
    Inventors: Reza Dana, Sunil Chauhan
  • Publication number: 20190008765
    Abstract: Methods and compositions for reducing the activity or number of memory Th17 cells in ocular tissue, and for treatment and/or prevention of ocular immunoinflammatory diseases are described.
    Type: Application
    Filed: January 6, 2017
    Publication date: January 10, 2019
    Inventors: Reza Dana, Sunil Chauhan, Yihe Chen
  • Patent number: 10117906
    Abstract: The invention provides methods and compositions for minimizing, preventing, or treating damage to corneal nerves by administering to a subject with such damage or at risk of exposure to such damage a composition which blocks an activity of an IL-1 cytokine and/or an IL-17 cytokine.
    Type: Grant
    Filed: January 11, 2010
    Date of Patent: November 6, 2018
    Assignee: The Schepens Eye Research Institute, Inc.
    Inventors: Reza Dana, Mohammad Dastjerdi, Sunil Chauhan
  • Patent number: 10105441
    Abstract: The present invention comprises a composition with means to inhibit the function of the inflammatory cytokine IL-1 and methods for using this composition to treat inflammatory disease of ocular and adnexal tissues by topical administration. The present invention also discloses devices for delivering this composition to target tissues.
    Type: Grant
    Filed: August 15, 2008
    Date of Patent: October 23, 2018
    Assignee: The Schepens Eye Research Institute, Inc.
    Inventors: Reza Dana, Mohammad Dastjerdi
  • Publication number: 20180256685
    Abstract: This application discloses ophthalmic formulations and methods for treating and preventing corneal haze and scarring with an hepatocyte growth factor (HGF) agent.
    Type: Application
    Filed: September 9, 2016
    Publication date: September 13, 2018
    Inventors: Sunil Chauhan, Reza Dana
  • Publication number: 20180184898
    Abstract: The present application includes methods, systems and computer readable storage devices for determining a color score for at least a portion of a biological tissue. The subject matter of the application is embodied in a method that includes obtaining a digital image of the biological tissue, and receiving a selection of a portion of the image as an evaluation area. The method also includes determining for each of a plurality of pixels within the evaluation area, a plurality of color components that are based on a Cartesian color space, and determining, from the color components, a hue value in a polar coordinate based color space. The method further includes determining a color value based on the hue value for each of the plurality of pixels, and assigning a color score to the evaluation area based on an average of the color values of the plurality of pixels.
    Type: Application
    Filed: December 28, 2017
    Publication date: July 5, 2018
    Inventors: Reza Dana, Francisco L. Amparo Pulido, Haobing Wang
  • Patent number: 10004395
    Abstract: The technology described in this document can be embodied in systems and computer-implemented methods for determining a score representing an amount of staining of the cornea. The methods include obtaining a digital image of the cornea stained with a tracer material, receiving a selection of a portion of the image, and processing, by a processing device, the selection to exclude areas with one or more artifacts to define an evaluation area. For each of a plurality of pixels within the evaluation area, a plurality of Cartesian color components are determined and a hue value in a polar coordinate based color space is calculated from the components. An amount of staining of the cornea is then determined as a function of the hue value. The methods also include assigning a score to the evaluation area based on the amount of staining calculated for the plurality of pixels.
    Type: Grant
    Filed: May 1, 2015
    Date of Patent: June 26, 2018
    Assignee: Massachusetts Eye and Ear Infirmary
    Inventors: Reza Dana, Francisco L. Amparo Pulido, Haobing Wang
  • Publication number: 20180092976
    Abstract: The invention comprises a composition with means to inhibit the function of the inflammatory cytokine IL-17 and methods for using this composition to treat IL-17-mediated ocular inflammatory disorders. The invention also discloses devices for delivering this composition to the eye.
    Type: Application
    Filed: December 14, 2017
    Publication date: April 5, 2018
    Inventors: Reza Dana, Sunil Chauhan
  • Patent number: 9877645
    Abstract: Provided herein are methods of evaluating efficacy of a treatment in a subject having eye inflammation (e.g., a subject having dry eye syndrome) and selecting a subject for participation in a clinical study. Also provided are methods of treating a subject having eye inflammation (e.g., a subject having dry eye syndrome).
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: January 30, 2018
    Assignee: Massachusetts Eye and Ear Infirmary
    Inventors: Pedram Hamrah, Reza Dana, Bernardo Cavalcanti, Andrea Cruzat
  • Patent number: 9872901
    Abstract: The invention comprises a composition with means to inhibit the function of the inflammatory cytokine IL-17 and methods for using this composition to treat IL-17-mediated ocular inflammatory disorders. The invention also discloses devices for delivering this composition to the eye.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: January 23, 2018
    Assignee: The Schepens Eye Research Institute, Inc.
    Inventors: Reza Dana, Sunil Chauhan
  • Patent number: 9854970
    Abstract: The present application includes methods, systems and computer readable storage devices for determining a color score for at least a portion of a biological tissue. The subject matter of the application is embodied in a method that includes obtaining a digital image of the biological tissue, and receiving a selection of a portion of the image as an evaluation area. The method also includes determining for each of a plurality of pixels within the evaluation area, a plurality of color components that are based on a Cartesian color space, and determining, from the color components, a hue value in a polar coordinate based color space. The method further includes determining a color value based on the hue value for each of the plurality of pixels, and assigning a color score to the evaluation area based on an average of the color values of the plurality of pixels.
    Type: Grant
    Filed: February 21, 2013
    Date of Patent: January 2, 2018
    Assignee: Massachusetts Eye & Ear Infirmary
    Inventors: Reza Dana, Francisco L. Amparo Pulido, Haobing Wang
  • Publication number: 20170290888
    Abstract: This application discloses ophthalmic formulations and methods for treating inflammatory disease and conditions of the ocular surface with one or more C-C chemokine receptor type 7 (CCR7) antagonists. The compositions may be formulated for subconjunctival or topical administration to the eye and are effective in the treatment of inflammatory disease and conditions of the ocular surface.
    Type: Application
    Filed: April 24, 2017
    Publication date: October 12, 2017
    Inventors: Reza Dana, Daniel Saban
  • Publication number: 20170188814
    Abstract: Provided herein are methods of evaluating efficacy of a treatment in a subject having eye inflammation (e.g., a subject having dry eye syndrome) and selecting a subject for participation in a clinical study. Also provided are methods of treating a subject having eye inflammation (e.g., a subject having dry eye syndrome).
    Type: Application
    Filed: January 20, 2017
    Publication date: July 6, 2017
    Inventors: Pedram Hamrah, Reza Dana, Bernardo Cavalcanti, Andrea Cruzat
  • Patent number: 9670277
    Abstract: This application discloses ophthalmic formulations and methods for treating inflammatory disease and conditions of the ocular surface with one or more C—C chemokine receptor type 7 (CCR7) antagonists. The compositions may be formulated for subconjunctival or topical administration to the eye and are effective in the treatment of inflammatory disease and conditions of the ocular surface.
    Type: Grant
    Filed: February 24, 2012
    Date of Patent: June 6, 2017
    Assignee: The Schepens Eye Reasearch Institute, Inc.
    Inventors: Reza Dana, Daniel Saban
  • Publication number: 20170055822
    Abstract: The technology described in this document can be embodied in systems and computer-implemented methods for determining a score representing an amount of staining of the cornea. The methods include obtaining a digital image of the cornea stained with a tracer material, receiving a selection of a portion of the image, and processing, by a processing device, the selection to exclude areas with one or more artifacts to define an evaluation area. For each of a plurality of pixels within the evaluation area, a plurality of Cartesian color components are determined and a hue value in a polar coordinate based color space is calculated from the components. An amount of staining of the cornea is then determined as a function of the hue value. The methods also include assigning a score to the evaluation area based on the amount of staining calculated for the plurality of pixels.
    Type: Application
    Filed: May 1, 2015
    Publication date: March 2, 2017
    Inventors: Reza Dana, Francisco L. Amparo Pulido, Haobing Wang
  • Patent number: 9549966
    Abstract: Provided herein are methods of evaluating efficacy of a treatment in a subject having eye inflammation (e.g., a subject having dry eye syndrome) and selecting a subject for participation in a clinical study. Also provided are methods of treating a subject having eye inflammation (e.g., a subject having dry eye syndrome).
    Type: Grant
    Filed: February 21, 2013
    Date of Patent: January 24, 2017
    Assignee: Massachusetts Eye & Ear Infirmary
    Inventors: Pedram Hamrah, Reza Dana, Bernardo Cavalcanti, Andrea Cruzat