Abstract: A Medication Reconciliation and Workflow system reconciles active medication orders in response to transitions in care setting and documents and automatically communicates reconciled medication information using electronic (e.g., HL7 CDA format) transactions and network (or other electronic) interfaces. A medication reconciliation system uses a detector for detecting a transition in care setting of a particular patient. A treatment validation processor, in response to a detected transition in care setting of the particular patient, automatically initiates review and safety checking of medications prescribed for the particular patient and provides information to a user enabling user validation of the review and safety checking. A documentation processor updates a medical record of the particular patient to include a record of the user validation and review, in response to a command by the user.