Patents by Inventor Rhiannon L. Nolan

Rhiannon L. Nolan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Quenching methods for background reduction in luminescence-based probe-target binding assays
    Patent number: 7202036
    Abstract: Background luminescence is reduced from a solution containing unbound luminescent probes, each having a first molecule that attaches to a target molecule and having an attached luminescent moiety, and luminescent probe/target adducts. Quenching capture reagent molecules are formed that are capable of forming an adduct with the unbound luminescent probes and having an attached quencher material effective to quench luminescence of the luminescent moiety. The quencher material of the capture reagent molecules is added to a solution of the luminescent probe/target adducts and binds in a proximity to the luminescent moiety of the unbound luminescent probes to quench luminescence from the luminescent moiety when the luminescent moiety is exposed to exciting illumination. The quencher capture reagent does not bind to probe molecules that are bound to target molecules and the probe/target adduct emission is not quenched.
    Type: Grant
    Filed: June 12, 2003
    Date of Patent: April 10, 2007
    Assignee: Los Alamos National Security, LLC
    Inventors: Hong Cai, Peter M Goodwin, Richard A. Keller, Rhiannon L. Nolan
  • Quenching methods for background reduction in luminescence-based probe-target binding assays
    Publication number: 20040253593
    Abstract: Background luminescence is reduced from a solution containing unbound luminescent probes, each having a first molecule that attaches to a target molecule and having an attached luminescent moiety, and luminescent probe/target adducts. Quenching capture reagent molecules are formed that are capable of forming an adduct with the unbound luminescent probes and having an attached quencher material effective to quench luminescence of the luminescent moiety. The quencher material of the capture reagent molecules is added to a solution of the luminescent probe/target adducts and binds in a proximity to the luminescent moiety of the unbound luminescent probes to quench luminescence from the luminescent moiety when the luminescent moiety is exposed to exciting illumination. The quencher capture reagent does not bind to probe molecules that are bound to target molecules and the probe/target adduct emission is not quenched.
    Type: Application
    Filed: June 12, 2003
    Publication date: December 16, 2004
    Inventors: Hong Cai, Peter M. Goodwin, Richard A. Keller, Rhiannon L. Nolan
  • Recombinant fluorescent protein microsphere calibration standard
    Patent number: 6326157
    Abstract: A method for making recombinant fluorescent protein standard particles for calibration of fluorescence instruments.
    Type: Grant
    Filed: March 5, 1999
    Date of Patent: December 4, 2001
    Assignee: The Regents of the University of California
    Inventors: John P. Nolan, Rhiannon L. Nolan, Teresa Ruscetti, Bruce E. Lehnert