Patents by Inventor Rhodemann Li

Rhodemann Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230414525
    Abstract: The present invention provides novel compositions and methods for targeted delivery of therapeutics. In particular, the invention provides compositions comprising a plurality of carriers, such as microbubbles, wherein at least one active agent is associated or co-administered with the plurality of carriers for delivery to a target site, e.g., an organ, a tissue, or a tumor site, in a subject. The present invention also provides methods for treating a disease or condition, methods of targeted delivery of an active agent, e.g., to a target site, in a subject, using the carriers based compositions of the invention. The present invention further provides apparatus, devices and methods for preparing the compositions of the present invention.
    Type: Application
    Filed: August 29, 2023
    Publication date: December 28, 2023
    Applicant: VESSELON, INC.
    Inventors: Rhodemann Li, Clayton Larsen, Ernest G. Schutt, Llew Keltner
  • Publication number: 20230058977
    Abstract: The present invention provides novel compositions and methods for targeted delivery of therapeutics. In particular, the invention provides compositions comprising a plurality of carriers, such as microbubbles, wherein at least one active agent is associated or co-administered with the plurality of carriers for delivery to a target site, e.g., an organ, a tissue, or a tumor site, in a subject. The present invention also provides methods for treating a disease or condition, methods of targeted delivery of an active agent, e.g., to a target site, in a subject, using the carriers based compositions of the invention. The present invention further provides apparatus, devices and methods for preparing the compositions of the present invention.
    Type: Application
    Filed: May 12, 2022
    Publication date: February 23, 2023
    Applicant: VESSELON, INC.
    Inventors: Rhodemann Li, Clayton Larsen, Ernest G. Schutt, Llew Keltner
  • Publication number: 20180001114
    Abstract: An apparatus and method for automatically lysing a clot to recanalize vessels using ultrasound, with or without nanoparticles, microbubbles, thrombolytic drugs or other agents, is described herein. At least one ultrasound transducer with a specified geometry, bandwidth and/or transmit pulse characteristics can generate a more uniform 3-dimensional volume of defocused acoustic energy into a target area of the body. When an agent (such as, but not limited to, microbubbles) is used to lyse a clot, a certain level of ultrasound energy may be desired in order to effect certain actions or states of the agent. Bone attenuation may present an issue inhibiting sufficient ultrasound energy from reaching the agent in order to attain the desired agent action. The relative patient dimensions and location of the clot may also present an issue.
    Type: Application
    Filed: December 15, 2015
    Publication date: January 4, 2018
    Inventors: Rhodemann Li, Clayton T. Larsen
  • Patent number: 8480744
    Abstract: A method for delivering a spinal implant into a vertebral space, including providing a spinal implant, providing a die member defining an opening sized to receive the implant while in an initial configuration, inserting the implant into the opening in the die member, displacing the implant relative to the die member, transitioning the implant from the initial configuration to a deformed configuration having a reduced lateral profile relative to the initial configuration, and discharging the implant from the die member and inserting the implant into the vertebral space while in the deformed configuration.
    Type: Grant
    Filed: July 14, 2006
    Date of Patent: July 9, 2013
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Lehmann K. Li, Rhodemann Li
  • Publication number: 20060253122
    Abstract: A method for delivering a spinal implant into a vertebral space, including providing a spinal implant, providing a die member defining an opening sized to receive the implant while in an initial configuration, inserting the implant into the opening in the die member, displacing the implant relative to the die member, transitioning the implant from the initial configuration to a deformed configuration having a reduced lateral profile relative to the initial configuration, and discharging the implant from the die member and inserting the implant into the vertebral space while in the deformed configuration.
    Type: Application
    Filed: July 14, 2006
    Publication date: November 9, 2006
    Inventors: Lehmann Li, Rhodemann Li
  • Patent number: 7081120
    Abstract: Instrumentation and method for delivering an implant into an intervertebral disc space, including a die member configured to transition the implant from an initial configuration to a deformed configuration having a reduced lateral profile suitable for insertion into the intervertebral disc space in a minimally invasive manner. In one embodiment, the die member includes an opening sized to receive the implant while in the initial configuration, and wherein relative displacement between the implant and the die member causes the implant to transition toward the reduced-profile deformed configuration. In a specific embodiment, the opening comprises an axial passage including a first portion having a rectangular cross-section corresponding to a substantially planar initial configuration of the implant, and a second portion having a circular cross-section corresponding to a substantially cylindrical deformed configuration of the implant.
    Type: Grant
    Filed: December 12, 2002
    Date of Patent: July 25, 2006
    Assignee: SDGI Holdings, Inc.
    Inventors: Lehmann K. Li, Rhodemann Li
  • Publication number: 20050070931
    Abstract: A method is for restricting food volume capacity of the stomach. The method comprises manipulating tissue from within the stomach to create an upper pouch and a lower pouch, and the tissue between the upper pouch and the lower pouch forming an opening therethrough, the upper pouch configured adjacent the gastroesophageal junction, the lower pouch configured adjacent the pylorus, and the opening having a periphery formed by drawing together the tissue. A device for creating a restriction in the stomach. The device comprises a retractor configured for deployment through the esophagus into the stomach; a plurality of arms selectively deployable from the retractor, each of the plurality of arms configured to position a securement device adjacent to a given location of tissue of the stomach from within the stomach; and deployment means for deploying the securement device positioned by each of the plurality of arms to the given location of the tissue of the stomach from within the stomach.
    Type: Application
    Filed: August 6, 2004
    Publication date: March 31, 2005
    Inventors: Rhodemann Li, Lehmann Li
  • Publication number: 20040210315
    Abstract: A prosthetic nucleus for implantation in a chamber of an intervertebral disc after removal of at least a portion of a damaged or degenerated nucleus from the chamber, comprising a wafer of biologically compatible, thin, flexible, and expandable material in a selected first configuration. The wafer is adapted to be re-shaped mechanically into a compact second configuration of cross-section sufficiently small to permit travel of the wafer through a cannula and into the disc chamber. The wafer is further adapted to substantially regain the first configuration thereof by memory upon entry into the disc chamber, and the wafer is adapted to react to an expansion-inducing agent in the disc chamber to expand to an enlarged and selected third configuration.
    Type: Application
    Filed: May 10, 2004
    Publication date: October 21, 2004
    Inventors: Lehmann K. Li, Rhodemann Li
  • Patent number: 6764514
    Abstract: A prosthetic nucleus for implantation in a chamber of an intervertebral disc after removal of at least a portion of a damaged or degenerated nucleus from the chamber, comprising a wafer of biologically compatible, thin, flexible, and expandable material in a selected first configuration. The wafer is adapted to be re-shaped mechanically into a compact second configuration of cross-section sufficiently small to permit travel of the wafer through a cannula and into the disc chamber. The wafer is further adapted to substantially regain the first configuration thereof by memory upon entry into the disc chamber, and the wafer is adapted to react to an expansion-inducing agent in the disc chamber to expand to an enlarged and selected third configuration.
    Type: Grant
    Filed: April 26, 2000
    Date of Patent: July 20, 2004
    Assignee: SDGI Holdings, Inc.
    Inventors: Lehmann K. Li, Rhodemann Li
  • Patent number: 6610079
    Abstract: A fastener system and procedure to secure a member in a medium. The system includes a tool to deliver both the member and a flowable, curable polymer onto, into or through the medium. The flowable polymer is injected into, through or around the member. As the flowable polymer cures, it acts as either a solid filler or as an adhesive to provide fixation for the member, or to enhance fixation of the member.
    Type: Grant
    Filed: June 30, 2000
    Date of Patent: August 26, 2003
    Assignee: Linvatec Corporation
    Inventors: Lehmann K. Li, Rhodemann Li
  • Publication number: 20030125748
    Abstract: Instrumentation and method for delivering an implant into an intervertebral disc space, including a die member configured to transition the implant from an initial configuration to a deformed configuration having a reduced lateral profile suitable for insertion into the intervertebral disc space in a minimally invasive manner. In one embodiment, the die member includes an opening sized to receive the implant while in the initial configuration, and wherein relative displacement between the implant and the die member causes the implant to transition toward the reduced-profile deformed configuration. In a specific embodiment, the opening comprises an axial passage including a first portion having a rectangular cross-section corresponding to a substantially planar initial configuration of the implant, and a second portion having a circular cross-section corresponding to a substantially cylindrical deformed configuration of the implant.
    Type: Application
    Filed: December 12, 2002
    Publication date: July 3, 2003
    Inventors: Lehmann K. Li, Rhodemann Li
  • Patent number: 6039761
    Abstract: An intervertebral spacer comprises a multiplicity of interconnected wall elements collapsible to a first configuration wherein the wall elements are disposed in a compact arrangement, and expandable to a second configuration wherein the wall elements are disposed in an expanded arrangement which is open at a generally planar top and a generally planar bottom thereof.
    Type: Grant
    Filed: February 12, 1997
    Date of Patent: March 21, 2000
    Assignee: Li Medical Technologies, Inc.
    Inventors: Lehmann K. Li, Rhodemann Li