Patents by Inventor Éric Marsault

Éric Marsault has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Conformationally-controlled biologically active macrocyclic small molecules as motilin antagonists or ghrelin agonists
    Patent number: 7452862
    Abstract: Novel spatially-defined macrocyclic compounds containing specific conformational control elements are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.
    Type: Grant
    Filed: August 2, 2004
    Date of Patent: November 18, 2008
    Assignee: Tranzyme Pharma, Inc.
    Inventors: Pierre Deslongchamps, Yves Dory, Mark Peterson, Kamel Benakli, Eric Marsault, Luc Ouellet, Mahesh Ramaseshan, Martin Vézina, Daniel Fortin, Ruoxi Lan, Shigui Li, Gérald Villeneuve, Hamid Hoveyda, Sylvie Beaubien, Graeme L Fraser
  • MACROCYCLIC GHRELIN RECEPTOR MODULATORS AND METHODS OF USING THE SAME
    Publication number: 20080194672
    Abstract: The present invention provides novel conformationally-defined macrocyclic compounds that can function as selective modulators of the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and subtypes, isoforms and variants thereof). Methods of synthesizing the novel compounds are also described herein. These compounds are useful as agonists of the ghrelin receptor and as medicaments for treatment and prevention of a range of medical conditions including, but not limited to, metabolic and/or endocrine disorders, gastrointestinal disorders, cardiovascular disorders, obesity and obesity-associated disorders, central nervous system disorders, bone disorders, genetic disorders, hyperproliferative disorders and inflammatory disorders.
    Type: Application
    Filed: February 8, 2008
    Publication date: August 14, 2008
    Inventors: Hamid Hoveyda, Graeme L. Fraser, Kamel Benakli, Sophie Beauchemin, Martin Brassard, David Drutz, Eric Marsault, Luc Ouellet, Mark L. Peterson, Zhigang Wang
  • Spatially-defined macrocyclic compounds useful for drug discovery
    Publication number: 20050137127
    Abstract: Novel spatially-defined macrocyclic compounds containing specific conformational control elements are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.
    Type: Application
    Filed: August 2, 2004
    Publication date: June 23, 2005
    Applicant: TRANZYME PHARMA INC
    Inventors: Pierre Deslongchamps, Yves Dory, Mark Peterson, Kamel Benakli, Eric Marsault, Luc Ouellet, Mahesh Ramaseshan, Martin Vezina, Daniel Fortin, Ruoxi Lan, Shigui Li, Gerald Villeneuve, Hamid Hoveyda, Sylvie Beaubien
  • Spatially-defined macrocycles incorporating peptide bond surrogates
    Publication number: 20050119169
    Abstract: Novel spatially-defined macrocyclic compounds incorporating peptide bond surrogates are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.
    Type: Application
    Filed: August 2, 2004
    Publication date: June 2, 2005
    Applicant: TRANZYME PHARMA INC.
    Inventors: Pierre Deslongchamps, Yves Dory, Luc Ouellet, Gerald Villeneuve, Mahesh Ramaseshan, Daniel Fortin, Mark Peterson, Hamid Hoveyda, Sylvie Beaubien, Eric Marsault
  • Macrocyclic antagonists of the motilin receptor
    Publication number: 20050054562
    Abstract: The present invention is directed to novel macrocyclic compounds of formula (I) and their pharmaceutically acceptable salts, hydrates or solvates: wherein R1, R2, R3, R4, R5, R6, n1, m, p Z1, Z2, and Z3 are as describe in the specification. The invention also relates to compounds of of formula (I) which are antagonists of the motilin receptor and are useful in the treatment of disorders associated with this receptor and with or with motility dysfunction.
    Type: Application
    Filed: June 18, 2004
    Publication date: March 10, 2005
    Applicant: TRANZYME PHARMA INC.
    Inventors: Graeme Fraser, Eric Marsault, Mark Peterson, Hamid Hoveyda, Sylvie Beaubien, Kamel Benakli
  • Preparation of phosphorothioate oligomers
    Patent number: 6861518
    Abstract: Methods and Intermediates for the Preparation of Oligomers Containing Diastereomerically Enriched Phosphorothioate Linkages are Disclosed.
    Type: Grant
    Filed: September 24, 2002
    Date of Patent: March 1, 2005
    Assignee: McGill University
    Inventors: George Just, Zhili Xin, Eric Marsault, Yi Jin, Jianchao Wang
  • Preparation of phosphorothioate oligomers
    Publication number: 20040097722
    Abstract: Methods and intermediates for the preparation of oligomers containing diastereomerically enriched phosphorothioate linkages are disclosed.
    Type: Application
    Filed: April 25, 2003
    Publication date: May 20, 2004
    Applicant: McGill University
    Inventors: George Just, Zhili Xin, Eric Marsault, Yi Jin
  • Preparation of phosphorothioate oligomers
    Publication number: 20030229219
    Abstract: Methods and intermediates for the preparation of oligomers containing diastereomerically enriched phosphorothioate linkages are disclosed.
    Type: Application
    Filed: April 25, 2003
    Publication date: December 11, 2003
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: George Just, Zhili Xin, Eric Marsault, Yi Jin
  • Phenoxylpropanolamines, method for the production thereof and pharmaceutical compositions containing the same
    Patent number: 6649627
    Abstract: The invention concerns compounds of formula (Ia) wherein R1a represents hydrogen, an —S(O)z —(C1-C4)Alk group, a —CO(C1-C4)Alk group, an —NHSO2—(C1-C4)Alk group, an NCHl (C1-C4) Alk group, a 2-furyl group or a halogen; R2 represents hydrogen or a (C1-C4)Alk group, a (C1-C4) alkoxyl group, a halogen, —COOH, —COO(C1-C4)Alk, —CN, —CONR3R4, —NO2, —SO2NH2, —NHSO2(C1-C4)Alk; m and n are independently 0, 1 or 2; R3 and R4 independently represent hydrogen or a (C1-C4)Alk group; Z is 1 or 2 and their salts or solvates, the pharmaceutical compositions that contain them, the process for their preparation, and intermediate synthesis products.
    Type: Grant
    Filed: March 26, 2001
    Date of Patent: November 18, 2003
    Assignee: Sanofi-Synthelabo
    Inventors: Roberto Cecchi, Tiziano Croci, Umberto Guzzi, Eric Marsault
  • Preparation of phosphorothioate oligomers
    Patent number: 6596857
    Abstract: Methods and intermediates for the preparation of oligomers containing diastereomerically enriched phosphorothioate linkages are disclosed.
    Type: Grant
    Filed: December 1, 1999
    Date of Patent: July 22, 2003
    Assignee: McGill University
    Inventors: George Just, Zhili Xin, Eric Marsault, Yi Jin
  • Preparation of phosphorothioate oligomers
    Publication number: 20030114660
    Abstract: Methods and Intermediates for the Preparation of Oligomers Containing Diastereomerically Enriched Phosphorothioate Linkages are Disclosed.
    Type: Application
    Filed: September 24, 2002
    Publication date: June 19, 2003
    Inventors: George Just, Zhili Xin, Eric Marsault, Yi Jin, Jianchao Wang
  • Preparation of phosphorothioate oligomers
    Patent number: 6476216
    Abstract: The present invention is directed to methods for solid phase nucleotide synthesis utilizing substituted imidazole catalysts.
    Type: Grant
    Filed: December 3, 1998
    Date of Patent: November 5, 2002
    Assignee: McGill University
    Inventors: George Just, Zhili Xin, Eric Marsault, Yi Jin, Jianchao Wang
  • Preparation of phosphorothioate and boranophosphate oligomers
    Patent number: 6160109
    Abstract: Methods and intermediates for the preparation of oligomers containing diastereomerically enriched phosphorothioate and boranophosphate linkages are disclosed.
    Type: Grant
    Filed: June 30, 1998
    Date of Patent: December 12, 2000
    Assignees: Isis Pharmaceuticals, Inc., McGill University
    Inventors: George Just, Zhili Xin, Eric Marsault, Yi Jin, Jianchao Wang, Muthiah Manoharan
  • Preparation of phosphorothioate oligomers
    Patent number: 6031092
    Abstract: Methods and intermediates for the preparation of oligomers containing diastereomerically enriched phosphorothioate linkages are disclosed.
    Type: Grant
    Filed: October 15, 1997
    Date of Patent: February 29, 2000
    Assignee: Mc Gill University
    Inventors: George Just, Zhili Xin, Eric Marsault, Yi Jin
  • Preparation of phosphorothioate oligomers
    Patent number: 5945521
    Abstract: Methods and intermediates for the preparation of oligomers containing diastereomerically enriched phosphorothioate linkages are disclosed.
    Type: Grant
    Filed: October 9, 1997
    Date of Patent: August 31, 1999
    Assignee: McGill University
    Inventors: George Just, Zhili Xin, Eric Marsault, Yi Jin
  • Preparation of chiral phosphorothioate oligomers
    Patent number: 5734041
    Abstract: Methods and intermediates for the preparation of oligomers containing diastereomerically enriched phosphorothioate linkages are disclosed.
    Type: Grant
    Filed: October 20, 1995
    Date of Patent: March 31, 1998
    Assignee: McGill University
    Inventors: George Just, Zhili Xin, Eric Marsault, Yi Jin