Abstract: Automated device for the controlled feeding of substances to animal containment recipients in an animal breeding facility, including at least one rack for such animal containment recipients, said racks being arranged in lines (1) comprising a plurality of animal containment recipients (2), in which said recipients are arranged in the form of a grid on the rack (1); wherein the device includes a robot (3) with a locomotion platform, a lifting mechanism, a feeding platform, a feeding circuit and a central processing unit, and travels on a horizontal, linear track (9) having a reflective strip (10). The automated device solves the problems of the prior art, as it travels between various lines of racks (1), preventing the need for installing individual systems for each rack (1), having high precision in terms of Cartesian coordinates when feeding the animals in the recipients (2), and including laser scanning sensors (30) and optical sensors for following a reflective strip (32).

Abstract: The present disclosure relates generally to compositions and methods for modulating cell surface receptor signaling by specifically recruiting membrane phosphatases, in cis, to a spatial proximity of a signal regulatory protein ? (SIRP?) molecule. More particularly, the disclosure provides novel multivalent protein-binding molecules that specifically bind SIRP? and antagonize the SIRP?-mediated signaling through recruitment of a phosphatase activity to dephosphorylate the intracellular domain of SIRP?. Also provided are compositions and methods useful for producing such molecules, methods for promoting maturation dendritic cells and for production of vaccine, as well as methods for the prevention and/or treatment of health conditions associated with the inhibition of signal transduction mediated by SIRP? and/or CD47.

Abstract: Disclosed herein are compositions and methods for modulating cell surface receptor signaling by specifically recruiting membrane phosphatases to a proximity of receptors of interest. This novel methodology, termed Receptor Inhibition by Phosphatase Recruitment (RIPR), represents a new approach to reducing and suppressing signal by receptors that signal through phosphorylation mechanisms. More particularly, the disclosure provides novel multivalent protein-binding molecules that specifically bind a cell surface receptor and antagonize the receptor signaling through recruitment of a phosphatase activity. Also provided are compositions and methods useful for producing such molecules, as well as methods for the treatment of diseases associated with the inhibition of signal transduction mediated by cell surface receptor.