Patents by Inventor Ricardo B. Maccioni

Ricardo B. Maccioni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Innovative blood platelets biomarker for early diagnosis of alzheimer's disease
    Patent number: 9012237
    Abstract: The present invention is directed to a method for early, non-invasive, rapid, efficient, reliable and accurate diagnose of Alzheimer's disease. The present invention particularly addresses obtaining blood samples, and stabilizing platelets from healthy persons and patients with probable cognitive impairment and/or Alzheimer's disease; extracting proteins from the platelets; identifying both monomeric and oligomeric tau proteins in the platelets with at least two monoclonal antibodies against the tau proteins, quantifying the amounts of the identified tau proteins, and comparing the amounts and protein profiles of the tau molecular species in the platelets of the healthy person and the patient.
    Type: Grant
    Filed: November 5, 2010
    Date of Patent: April 21, 2015
    Assignee: Servicios Cientificos Neuroinnovation Limitada
    Inventors: Ricardo B. Maccioni, Gonzalo Farias
  • Method for preventing protein aggregation and treating Alzheimer's disease with a quinoline derivative compound
    Patent number: 8198300
    Abstract: Method for the prevention of the tau protein aggregation and treating Alzheimer's disease by administering a quinoline derivative compound of formula wherein R2 is 2-(4-aminophenyl) or 2-(4-methylphenyl) and R6 is methyl as an inhibitor of the tau protein aggregation.
    Type: Grant
    Filed: April 29, 2010
    Date of Patent: June 12, 2012
    Assignee: Universidad De Chile
    Inventors: Ricardo B. Maccioni, Leonardo P Navarrete, Aurelio San Martin
  • INNOVATIVE BLOOD PLATELETS BIOMARKER FOR EARLY DIAGNOSIS OF ALZHEIMER'S DISEASE
    Publication number: 20120058573
    Abstract: The present invention is directed to a method for early, non-invasive, rapid, efficient, reliable and accurate diagnose of Alzheimer's disease. The present invention particularly addresses obtaining blood samples, and stabilizing platelets from healthy persons and patients with probable cognitive impairment and/or Alzheimer's disease; extracting proteins from the platelets; identifying both monomeric and oligomeric tau proteins in the platelets with at least two monoclonal antibodies against the tau proteins, quantifying the amounts of the identified tau proteins, and comparing the amounts and protein profiles of the tau molecular species in the platelets of the healthy person and the patient.
    Type: Application
    Filed: November 5, 2010
    Publication date: March 8, 2012
    Inventors: Ricardo B. Maccioni, Gonzalo Farias