Abstract: The invention relates to a method for production of tyrosol, wherein a transgenic bacterial cell that heterologously expresses phenylpyruvate decarboxylase and that overexpresses phospho-2-dehydro-3-deoxyheptonate and prephenate dehydrogenase, and wherein pheAL and feaB are both inactivated or removed, is grown in a medium comprising a metabolic precursor of phosphoenolpyruvate (PEP) and erythrose 4-phosphate (E4P), particularly glucose, and optionally, phenylalanine as a supplement; and tyrosol is extracted from said medium. The invention also relates to a method for production of salidroside, wherein the transgenic cell additionally heterologously expresses uridine diphosphate dependent glycosyltransferase (UGT85A1, EC:2.4.1.

Abstract: The present disclosure relates to a beverage font lens comprising a housing accommodating a customer display panel embedded in the housing and visible through a first window; an operator display panel embedded in the housing and visible through a second window opposite the first window; and a microcontroller unit configured to display information on the customer display panel and the operator display panel. The present disclosure further relates to an information system for monitoring a beverage dispensing system, said information system comprising one or more measuring devices, one or more electronic devices, at least one cloud server suitable for cloud computing, and one or more microcontroller units, each of said microcontroller units embedded in a beverage font lens.

Abstract: A computer-implemented method for predicting knowledge elements in answer to requests for information, and an associated system that processes the information request (1) made using an intermediate predictive model (5) and a knowledge element prediction fit model (8) to generate a set of fitted knowledge elements to prepare an answer, associated with their respective probabilities of use (12), as a suggestion for the preparation of an answer to an information request (15). The suggested knowledge elements are corrected and/or updated to prepare answers based on historical data, such as: data predicted by the intermediate predictive model (5), answers sent to requesters (15), contents of one or more knowledge elements used in the answers (17) and/or feedback data on the relevance of the answers (21) sent.

Abstract: The present invention relates to the production of a kraftliner paper in a one to three layer construction, with a short chemical fiber composition ranging from 70% to 100%, and the remaining fraction completed with long chemical fiber. Preferably, to solve quality and cost problems, production with 100% short eucaliptus chemical fiber and surface application of 0-30 Kg starch/t paper is maximized. The present invention further relates to the box produced with the disclosed paper.

Abstract: A wellhead assembly includes a wellhead housing having a bore with a wellhead housing sidewall and a longitudinal axis. A hanger lands in the bore, the hanger having a hanger sidewall. Parallel circumferentially extending hanger sidewall ridges are located on the hanger sidewall. Each of the hanger sidewall ridges have upper and lower flanks that converge to a crest. Hanger sidewall bands are located between adjacent ones of the hanger sidewall ridges. A metal seal ring has an outer seal surface in metal-to-metal sealing engagement with the wellhead housing sidewall and an inner seal surface in metal-to-metal sealing engagement with the hanger sidewall bands. Crests of the hanger sidewall ridges embed into the inner seal surface to restrict relative movement between the hanger and the seal ring. A recess extends through each of the hanger sidewall ridges from the upper flank to the lower flank to allow any fluid trapped between the hanger sidewall ridges to flow out.

Abstract: A wellhead assembly includes a wellhead housing having a bore with a wellhead housing sidewall and a longitudinal axis. A hanger lands in the bore, the hanger having a hanger sidewall. Parallel circumferentially extending hanger sidewall ridges are located on the hanger sidewall. Each of the hanger sidewall ridges have upper and lower flanks that converge to a crest. Hanger sidewall bands are located between adjacent ones of the hanger sidewall ridges. A metal seal ring has an outer seal surface in metal-to-metal sealing engagement with the wellhead housing sidewall and an inner seal surface in metal-to-metal sealing engagement with the hanger sidewall bands. Crests of the hanger sidewall ridges embed into the inner seal surface to restrict relative movement between the hanger and the seal ring. A recess extends through each of the hanger sidewall ridges from the upper flank to the lower flank to allow any fluid trapped between the hanger sidewall ridges to flow out.

Abstract: An apparatus and method for cleaning fabrication equipment, such as for example wire feed tips provided on welding guns. Equipment of that nature usually includes an outlet through which joining or filling material is dispensed and which may easily become blocked by weld splatter or the like when in such close proximity to the work piece being fabricated. The apparatus provides a support means for holding the equipment, cleaning means for removing debris from the equipment, and control means for effecting relative movement of the support means and cleaning means in a swift and efficient manner.

Abstract: An earth ground testing cable is configured to electrically couple an electrode to a measurement unit. The cable may comprise an outer surface having at least a first marking and a second marking. The first marking and the second marking define a segment of cable having a length that corresponds to a spacing distance between the electrode and at least one other electrode for performing an earth ground test. The spacing distance may be determined based on electrical interference properties of a measurement unit and the one or more electrodes. The ground earth testing cable may be part of a system and may be used to determine positioning for electrodes. The cable may also couple an electrode to the testing unit, so that an earth ground reading is determined.

Abstract: An apparatus and method for cleaning fabrication equipment, such as for example wire feed tips provided on welding guns. Equipment of that nature usually includes an outlet through which joining or filling material is dispensed and which may easily become blocked by weld splatter or the like when in such close proximity to the work piece being fabricated. The apparatus provides a support means for holding the equipment, cleaning means for removing debris from the equipment, and control means for effecting relative movement of the support means and cleaning means in a swift and efficient manner.

Abstract: Electrochromic materials can be used in a multitude of fields to yield different effects. Importantly, a single chromatic variation may be used as communication means. Systems are described that use chromatic variations in culturally-meaningful ways.

Abstract: Vaccine composition containing IL-15 for active immunization to treatment diseases related to over-expression of this cytokine. The technical aim pursued in this invention is to inhibit IL-15 activity through development of a therapeutic vaccine which elicits IL-15 neutralizing antibodies in the immunized host. IL-15 can be presented in this vaccine composition either alone or coupled to a carrier such as the P64k protein with a vaccine adjuvant such as Aluminum hydroxide. Besides, this invention is related to the use of this vaccine for treatment of Rheumatoid arthritis and other IL-15 over-expressing related diseases, and leukemia, where this cytokine acts as a growth factor.

Abstract: This invention is related to the Molecular Pharmacology field and especially to the development of peptides useful for treating epithelial tumors and mainly those associated to oncogenic types of HPVs. The main objective of this invention is to identify peptides whose structure permits to block the Casein Kinase II (CKII) phosphorylation domain by direct interaction with such a site. In the present invention it is shown eleven cyclic peptides with different aminoacid sequences which inhibit the CKII phosphorylation in vitro, exhibit cytotoxicity on HPV-16 transformed cells (CaSki) and also increase the sensitivity of these cells to the cytostatic effect of interferon (IFN). Furthermore, the invention relates to the use of these peptides conjugated or fused to other peptides and chemical compounds which penetrates into cells as well as with the use of both peptide and chemical mimetic molecules.

Abstract: This invention is related to the Molecular Pharmacology field and especially to the development of peptides useful for treating epithelial tumors and mainly those associated to oncogenic types of HPVs. The main objective of this invention is to identify peptides whose structure permits to block the Casein Kinase II (CKII) phosphorylation domain by direct interaction with such a site. In the present invention it is shown eleven cyclic peptides with different aminoacid sequences which inhibit the CKII phosphorylation in vitro, exhibit cytotoxicity on HPV-16 transformed cells (CaSki) and also increase the sensitivity of these cells to the cytostatic effect of interferon (IFN). Furthermore, the invention relates to the use of these peptides conjugated or fused to other peptides and chemical compounds which penetrates into cells as well as with the use of both peptide and chemical mimetic molecules.

Abstract: This invention is related to the Molecular Pharmacology field and especially to the development of peptides useful for treating epithelial tumors and mainly those associated to oncogenic types of HPVs. The main objective of this invention is to identify peptides whose structure permits to block the Casein Kinase II (CKII) phosphorylation domain by direct interaction with such a site. In the present invention it is shown eleven cyclic peptides with different aminoacid sequences which inhibit the CKII phosphorylation in vitro, exhibit cytotoxicity on HPV-16 transformed cells (CaSki) and also increase the sensitivity of these cells to the cytostatic effect of interferon (IFN). Furthermore, the invention relates to the use of these peptides conjugated or fused to other peptides and chemical compounds which penetrates into cells as well as with the use of both peptide and chemical mimetic molecules.

Abstract: The present invention is related to the obtaining of chimeric chains coding for proteins capable of inducing, in the recipient, a serotype-specific and protective humoral immune response against the infection by the Dengue virus, thus eliminating the effects of the serotype-nonespecific viral immunoenhancement that causes hemorrhagies and clinical complications described for this kind of pathology. These chimeric chains of nucleic acids are composed by the specific combination of fragments belonging to the gene of a mutated protein from Neisseria meningitidis with dehydrogenase activity and fragments that codify for a region of the envelope (E) protein from the Dengue virus which, when inserted to an expression vector, give rise to chimeric proteins with particular properties. The resultant chimeric molecules from this invention are applicable to the pharmaceutical industry for the obtaining of vaccine preparations and diagnostic means of high serotype-specificity to be used in humans.

Abstract: A method and processing system for generating a workflow graph from empirical data of a process are described. Data for multiple instances of a process are obtained, the data including information about task ordering. The processing system analyzes occurrences of tasks to identify order constraints. A set of nodes representing tasks is partitioned into a series of subsets, where no node of a given subset is constrained to precede any other node of the given subset unless said pair of nodes are conditionally independent given one or more nodes in an immediately preceding subset, and such that no node of a following subset is constrained to precede any node of the given subset. Nodes of each subset are connected to nodes of each adjacent subset with edges based upon the order constraints and based upon conditional independence tests applied to subsets of nodes, thereby providing a workflow graph.

Abstract: This invention is related to the Molecular Pharmacology field and especially to the development of peptides useful for treating epithelial tumors and mainly those associated to oncogenic types of HPVs. The main objective of this invention is to identify peptides whose structure permits to block the Casein Kinase II (CKII) phosphorylation domain by direct interaction with such a site. In the present invention it is shown eleven cyclic peptides with different aminoacid sequences which inhibit the CKII phosphorylation in vitro, exhibit cytotoxicity on HPV-16 transformed cells (CaSki) and also increase the sensitivity of these cells to the cytostatic effect of interferon (IFN). Furthermore, the invention relates to the use of these peptides conjugated or fused to other peptides and chemical compounds which penetrates into cells as well as with the use of both peptide and chemical mimetic molecules.