Patents by Inventor Riccardo Gottardi
Riccardo Gottardi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240093157Abstract: Disclosed herein are various bioreactor devices and systems for growing cellular material, and related methods of growing cellular material. In some cases, a system can include a well plate having a plurality of wells and a bioreactor situated in each well of the well plate. In some cases, a bioreactor can include an inner body which divides the bioreactor into several distinct chambers and facilitates the growth of a multi-tissue sample in the bioreactor. In some cases, a system can include a mechanical actuator situated to mechanically stress tissues grown in a bioreactor.Type: ApplicationFiled: November 15, 2023Publication date: March 21, 2024Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Rocky S. Tuan, Hang Lin, Thomas P. Lozito, Peter Alexander, Douglas Allen Nelson, Jr., Riccardo Gottardi
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Patent number: 11845961Abstract: Disclosed herein are various bioreactor devices and systems for growing cellular material, and related methods of growing cellular material. In some cases, a system can include a well plate having a plurality of wells and a bioreactor situated in each well of the well plate. In some cases, a bioreactor can include an inner body which divides the bioreactor into several distinct chambers and facilitates the growth of a multi-tissue sample in the bioreactor. In some cases, a system can include a mechanical actuator situated to mechanically stress tissues grown in a bioreactor.Type: GrantFiled: January 19, 2021Date of Patent: December 19, 2023Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Rocky S. Tuan, Hang Lin, Thomas P. Lozito, Peter Alexander, Douglas Allen Nelson, Jr., Riccardo Gottardi
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Patent number: 11318103Abstract: Methods for inhibiting tissue ossification or calcification in a subject, comprising administering a therapeutically effective amount of BMP I inhibitor-loaded microparticles to a subject in need thereof, wherein the administration provides local and sustained release of the BMP I inhibitor thereby inhibiting tissue ossification or calcification.Type: GrantFiled: November 29, 2018Date of Patent: May 3, 2022Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, Ri.Med FoundationInventors: Riccardo Gottardi, Peter Alexander, Patrick A. Bianconi, Steven R. Little
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Publication number: 20210386825Abstract: The present invention provides microparticles that induce the migration of multipotent stem cells to the anatomical site of the microparticles. Various release profiles are demonstrated that depend upon the relative concentration of alginate in the chemokine-loaded microparticle. Local administration and/or intraarticular injection of the microparticles are useful in conditions such as osteoarthritis. Targeted systemic delivery of the alginate chemokine microparticles to distant anatomical sites subjected to autoimmune disease symptomology can be performed by encapsulation within liposomes having targeting ligands. Consequently, upon the creation of the appropriate chemokine gradient, multipotent stem cells will migrate to the distant anatomical site where the liposomes are attached.Type: ApplicationFiled: August 30, 2021Publication date: December 16, 2021Applicants: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, Ri.MED FoundationInventors: Steven R. Little, Riccardo Gottardi, Mintai Peter Hwang, Daniel DeSantis
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Patent number: 11154858Abstract: Disclosed herein are various bioreactor devices and systems for growing cellular material, and related methods of growing cellular material. In some cases, a system can include a bioreactor system having one or more wells with at least one fluidic passageway coupled to each well to feed fluids to biological material being developed inside the well. In some cases, a bioreactor system can include a main body comprising the perimeter of the well and the fluidic passageways, a cover that forms the top of the well and provides optical access into the well, and a base that forms the bottom surface of the well. The cover and base can be attached and detached from the main body to seal the well closed and to physically access the contents of the well.Type: GrantFiled: October 6, 2016Date of Patent: October 26, 2021Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Riccardo Gottardi, Peter Alexander, Bryan Romell, Rocky S. Tuan
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Patent number: 11129875Abstract: The present invention provides microparticles that induce the migration of multipotent stem cells to the anatomical site of the microparticles. Various release profiles are demonstrated that depend upon the relative concentration of alginate in the chemokine-loaded microparticle. Local administration and/or intraarticular injection of the microparticles are useful in conditions such as osteoarthritis. Targeted systemic delivery of the alginate chemokine microparticles to distant anatomical sites subjected to autoimmune disease symptomology can be performed by encapsulation within liposomes having targeting ligands. Consequently, upon the creation of the appropriate chemokine gradient, multipotent stem cells will migrate to the distant anatomical site where the liposomes are attached.Type: GrantFiled: January 7, 2019Date of Patent: September 28, 2021Assignees: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, RI.MED FOUNDATIONInventors: Steven R. Little, Riccardo Gottardi, Mintai Peter Hwang, Daniel DeSantis
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Publication number: 20210139859Abstract: Disclosed herein are various bioreactor devices and systems for growing cellular material, and related methods of growing cellular material. In some cases, a system can include a well plate having a plurality of wells and a bioreactor situated in each well of the well plate. In some cases, a bioreactor can include an inner body which divides the bioreactor into several distinct chambers and facilitates the growth of a multi-tissue sample in the bioreactor. In some cases, a system can include a mechanical actuator situated to mechanically stress tissues grown in a bioreactor.Type: ApplicationFiled: January 19, 2021Publication date: May 13, 2021Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Rocky S. Tuan, Hang Lin, Thomas P. Lozito, Peter Alexander, Douglas Allen Nelson, JR., Riccardo Gottardi
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Patent number: 10900023Abstract: Disclosed herein are various bioreactor devices and systems for growing cellular material, and related methods of growing cellular material. In some cases, a system can include a well plate having a plurality of wells and a bioreactor situated in each well of the well plate. In some cases, a bioreactor can include an inner body which divides the bioreactor into several distinct chambers and facilitates the growth of a multi-tissue sample in the bioreactor. In some cases, a system can include a mechanical actuator situated to mechanically stress tissues grown in a bioreactor.Type: GrantFiled: August 22, 2014Date of Patent: January 26, 2021Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Rocky S. Tuan, Hang Lin, Thomas P. Lozito, Peter Alexander, Douglas A. Nelson, Jr., Riccardo Gottardi
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Publication number: 20200270561Abstract: Disclosed mechanical stimulator systems can maintain the sterility of biological samples within a multi-well plate while mechanically stimulating the samples. The systems disclosed herein allow for the individual activation by mechanical compression of a high number of samples at the same time, while maintaining sterility of the samples. The well plates, guides, actuations pistons, and other components of the disclosed systems can be configured to be contained in or adjacent to an incubator that can control properties such as gas levels and temperature while at the same time allowing for the mechanical actuation of the biological samples.Type: ApplicationFiled: October 19, 2018Publication date: August 27, 2020Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, Fondazione Ri.MEDInventors: Davide Marino, Riccardo Gottardi, Rocky Sung Chi Tuan
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Publication number: 20190209651Abstract: The present invention provides microparticles that induce the migration of multipotent stem cells to the anatomical site of the microparticles. Various release profiles are demonstrated that depend upon the relative concentration of alginate in the chemokine-loaded microparticle. Local administration and/or intraarticular injection of the microparticles are useful in conditions such as osteoarthritis. Targeted systemic delivery of the alginate chemokine microparticles to distant anatomical sites subjected to autoimmune disease symptomology can be performed by encapsulation within liposomes having targeting ligands. Consequently, upon the creation of the appropriate chemokine gradient, multipotent stem cells will migrate to the distant anatomical site where the liposomes are attached.Type: ApplicationFiled: January 7, 2019Publication date: July 11, 2019Inventors: Steven R. Little, Riccardo Gottardi, Mintai Peter Hwang, Daniel DeSantis
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Publication number: 20190142758Abstract: Methods for inhibiting tissue ossification or calcification in a subject, comprising administering a therapeutically effective amount of BMP I inhibitor-loaded microparticles to a subject in need thereof, wherein the administration provides local and sustained release of the BMP I inhibitor thereby inhibiting tissue ossification or calcification.Type: ApplicationFiled: November 29, 2018Publication date: May 16, 2019Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Riccardo Gottardi, Peter Alexander, Patrick A. Bianconi, Steven R. Little
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Publication number: 20190076840Abstract: Disclosed herein are various bioreactor devices and systems for growing cellular material, and related methods of growing cellular material. In some cases, a system can include a bioreactor system having one or more wells with at least one fluidic passageway coupled to each well to feed fluids to biological material being developed inside the well. In some cases, a bioreactor system can include a main body comprising the perimeter of the well and the fluidic passageways, a cover that forms the top of the well and provides optical access into the well, and a base that forms the bottom surface of the well. The cover and base can be attached and detached from the main body to seal the well closed and to physically access the contents of the well.Type: ApplicationFiled: October 6, 2016Publication date: March 14, 2019Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Riccardo Gottardi, Peter Alexander, Bryan Romell, Rocky Sung Chi Tuan
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Patent number: 10195252Abstract: The present invention provides microparticles that deliver in vivo predictable release profiles of at least one chemokine to create a biomimetic chemokine concentration gradient that induces the migration of multipotent stem cells to the anatomical site of the microparticles. Various release profiles are demonstrated that depend upon the relative concentration of alginate in the chemokine-loaded microparticle. Local administration and/or intraarticular injection of the microparticles are useful in conditions such as osteoarthritis. Targeted systemic delivery of the alginate chemokine microparticles to distant anatomical sites subjected to autoimmune disease symptomology can be performed by encapsulation within liposomes having targeting ligands. Consequently, upon the creation of the appropriate chemokine gradient, multipotent stem cells will migrate to the distant anatomical site where the liposomes are attached.Type: GrantFiled: August 1, 2013Date of Patent: February 5, 2019Assignee: University Of Pittsburgh—Of The Commonwealth System of Higher EducationInventors: Steven R. Little, Riccardo Gottardi, Mintai Peter Hwang, Daniel DeSantis
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Patent number: 10179111Abstract: Methods for inhibiting tissue ossification or calcification in a subject, comprising administering a therapeutically effective amount of BMP I inhibitor-loaded microparticles to a subject in need thereof, wherein the administration provides local and sustained release of the BMP I inhibitor thereby inhibiting tissue ossification or calcification.Type: GrantFiled: March 5, 2015Date of Patent: January 15, 2019Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Riccardo Gottardi, Peter Alexander, Patrick A. Bianconi, Steven R. Little
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Publication number: 20170014349Abstract: Methods for inhibiting tissue ossification or calcification in a subject, comprising administering a therapeutically effective amount of BMP I inhibitor-loaded microparticles to a subject in need thereof, wherein the administration provides local and sustained release of the BMP I inhibitor thereby inhibiting tissue ossification or calcification.Type: ApplicationFiled: March 5, 2015Publication date: January 19, 2017Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Riccardo Gottardi, Peter Alexander, Patrick A. Bianconi, Steven R. Little
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Publication number: 20160201037Abstract: Disclosed herein are various bioreactor devices and systems for growing cellular material, and related methods of growing cellular material. In some cases, a system can include a well plate having a plurality of wells and a bioreactor situated in each well of the well plate. In some cases, a bioreactor can include an inner body which divides the bioreactor into several distinct chambers and facilitates the growth of a multi-tissue sample in the bioreactor. In some cases, a system can include a mechanical actuator situated to mechanically stress tissues grown in a bioreactor.Type: ApplicationFiled: August 22, 2014Publication date: July 14, 2016Inventors: Rocky S. TUAN, Hang LIN, Thomas P. LOZITO, Peter ALEXANDER, Douglas A. NELSON, JR., Riccardo GOTTARDI
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Publication number: 20150265677Abstract: The present invention provides microparticles that deliver in vivo predictable release profiles of at least one chemokine to create a biomimetic chemokine concentration gradient that induces the migration of multipotent stem cells to the anatomical site of the microparticles. Various release profiles are demonstrated that depend upon the relative concentration of alginate in the chemokine-loaded microparticle. Local administration and/or intraarticular injection of the microparticles are useful in conditions such as osteoarthritis. Targeted systemic delivery of the alginate chemokine microparticles to distant anatomical sites subjected to autoimmune disease symptomology can be performed by encapsulation within liposomes having targeting ligands. Consequently, upon the creation of the appropriate chemokine gradient, multipotent stem cells will migrate to the distant anatomical site where the liposomes are attached.Type: ApplicationFiled: August 1, 2013Publication date: September 24, 2015Inventors: Steven R. Little, Riccardo Gottardi, Mintai Peter Hwang
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Publication number: 20150211797Abstract: The invention relates to a device having a bottom, side walls and a ceiling, which together define a channel, as well as transportation means, extending in an axial direction of said channel from an entry port of the channel to an exit port of said channel, for transferring a metallurgical material from said entry port to said exit port.Type: ApplicationFiled: June 28, 2012Publication date: July 30, 2015Inventors: Stefano Miani, Riccardo Gottardi