Patents by Inventor Rich H. Griffey

Rich H. Griffey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the synthesis of 2?-O-substituted pyrimidines and oligomeric compounds therefrom
    Patent number: 6642367
    Abstract: Oligonucleotide analogs are disclosed having pyrimidine monomeric sub-units therein that are modified at the 2′ and 5′ positions. Monomeric sub-units having these modifications may be further modified at the 2′ position. Improved processes for the synthesis of 2′-O-substituted pyrimidine nucleosides are also provided. The processes feature alkylation of a 2,2′-anhydropyrimidine nucleoside or a 2S,2′-anhydropyrimidine nucleoside with a weak nucleophile in the presence of a Lewis acid.
    Type: Grant
    Filed: December 22, 2000
    Date of Patent: November 4, 2003
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Yogesh S. Sanghvi, Kelly G. Sprankle, Bruce S. Ross, Rich H. Griffey, Robert H. Springer
  • Process for the synthesis of 2' -O-substituted pyrimidines and oligomeric compounds therefrom
    Publication number: 20030050454
    Abstract: oligonucleotide analogs are disclosed having pyrimidine monomeric sub-units therein that are modified at the 2′ and 5′ positions. Monomeric sub-units having these modifications may be further modified at the 2′ position. Improved processes for the synthesis of 2′-O-substituted pyrimidine nucleosides are also provided. The processes feature alkylation of a 2,2′-anhydropyrimidine nucleoside or a 2S,2′-anhydropyrimidine nucleoside with a weak nucleophile in the presence of a Lewis acid.
    Type: Application
    Filed: December 22, 2000
    Publication date: March 13, 2003
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Yogesh S. Sanghvi, Kelly G. Sprankle, Bruce S. Ross, Rich H. Griffey, Robert H. Springer
  • Process for the synthesis of 2?-O-substituted pyrimidines and oligomeric compounds therefrom
    Patent number: 6222025
    Abstract: Oligonucleotide analogs are disclosed having pyrimidine monomeric sub-units therein that are modified at the 2′ and 5 positions. Monomeric sub-units having these modifications may be further modified at the 2 position. Improved processes for the synthesis of 2′-O-substituted pyrimidine nucleosides are also provided. The processes feature alkylation of a 2,2′-anhydropyrimidine nucleoside or a 2S,2′-anhydropyrimidine nucleoside with a weak nucleophile in the presence of a Lewis acid.
    Type: Grant
    Filed: January 7, 1998
    Date of Patent: April 24, 2001
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Yogesh S. Sanghvi, Kelly G. Sprankle, Bruce S. Ross, Rich H. Griffey, Robert H. Springer
  • Oligomeric compounds having pyrimidine nucleotide (S) with 2'and 5 substitutions
    Patent number: 6166197
    Abstract: Oligonucleotide analogs are disclosed having pyrimidine monomeric sub-units therein that are modified at the 2' and 5 positions. Monomeric sub-units having these modifications may be further modified at the 2 position.
    Type: Grant
    Filed: March 6, 1995
    Date of Patent: December 26, 2000
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Yogesh S. Sanghvi, Kelly G. Sprankle, Bruce S. Ross, Rich H. Griffey