Abstract: Binding members for sodium channel Nav1.7 and their use in medicine including for treatment of pain or epilepsy. Binding members comprise a fusion protein containing a Nav1.7-binding peptide, e.g., venom toxin peptide or knottin (“donor diversity scaffold domain”) inserted within an antibody variable domain (“recipient diversity scaffold domain”), and a partner domain (e.g., antibody variable domain), optionally wherein the partner domain enhances specificity of binding to Nav1.7 over other sodium channels.

Abstract: A voting apparatus for receiving a ballot paper comprises a voting aid for overlying the ballot paper, the voting aid comprising a respective ballot marking aid for each voting option of the ballot paper. The apparatus includes an audio system and an activation button for voting option. The audio system audibly renders the relevant ballot information in response to operation of any one of the buttons.

Abstract: Electrophoresis is used to identify presence of a target compound in a patient sample based on a charge state of the compound and a label. The charge state of the compound correlates to a total net charge of a binder conjugated to the compound. The bound complex or “bound complex” with the label is then applied to the electrophoresis substrate. An electric potential is applied to the substrate for a time period and causes the labeled bound complex to migrate toward the electrode with opposite charge of the labeled bound complex at a migration velocity to form a migration pattern over the time period. At some time during or at the end of the time period, the labeled bound complex produces a bound complex band as a result of its migration across the substrate. The presence of the compound is identified based on the labeled bound complex band and one or both of the migration pattern and the migration velocity.

Abstract: Electrophoresis is used to identify presence of a target compound in a patient sample based on a charge state of the compound and a label. The charge state of the compound correlates to a total net charge of a binder conjugated to the compound. The bound complex or “bound complex” with the label is then applied to the electrophoresis substrate. An electric potential is applied to the substrate for a time period and causes the labeled bound complex to migrate toward the electrode with opposite charge of the labeled bound complex at a migration velocity to form a migration pattern over the time period. At some time during or at the end of the time period, the labeled bound complex produces a bound complex band as a result of its migration across the substrate. The presence of the compound is identified based on the labeled bound complex band and one or both of the migration pattern and the migration velocity.

Abstract: Electrophoresis is used to identify presence of a target compound in a patient sample based on a charge state of the compound and a label. The charge state of the compound correlates to a total net charge of a binder conjugated to the compound. The bound complex or “bound complex” with the label is then applied to the electrophoresis substrate. An electric potential is applied to the substrate for a time period and causes the labeled bound complex to migrate toward the electrode with opposite charge of the labeled bound complex at a migration velocity to form a migration pattern over the time period. At some time during or at the end of the time period, the labeled bound complex produces a bound complex band as a result of its migration across the substrate. The presence of the compound is identified based on the labeled bound complex band and one or both of the migration pattern and the migration velocity.

Abstract: This invention relates to a container for storing an aqueous hydrogen peroxide solution, the container comprising: walls formed from a gas permeable, liquid impermeable polymeric material, the walls being capable of permitting gas to escape from the container through the walls to avoid build-up of pressure within the container while retaining liquid within the container, the polymeric material having a gas transmission rate in the range from about 0.05 to about 0.5 cubic centimeters of gas per square centimeter of polymeric material per 24 hours at 25° C.

Abstract: A tool is configured for preparing an end of a pre-insulated tubing bundle having a central tube having a diameter and an outer insulation covering have a diameter. The tool includes a body having first and second body sections joined to one another and movable between an open position and a closed position. The body sections, when joined to one another define a circular central opening. The circular central opening has a diameter about equal to the diameter of the outer insulation covering. A cutting blade is positioned in one of the first and second section sections extending inwardly of the circular central opening a distance equal to one-half of a difference between the diameter of the outer insulation covering and the diameter of the central tube.

Abstract: A tool is configured for preparing an end of a pre-insulated tubing bundle having a central tube having a diameter and an outer insulation covering have a diameter. The tool includes a body having first and second body sections joined to one another and movable between an open position and a closed position. The body sections, when joined to one another define a circular central opening. The circular central opening has a diameter about equal to the diameter of the outer insulation covering. A cutting blade is positioned in one of the first and second section sections extending inwardly of the circular central opening a distance equal to one-half of a difference between the diameter of the outer insulation covering and the diameter of the central tube.

Abstract: The present invention generally relates to compositions for use in lubricating oils. In certain aspects, the present invention is generally directed to boroxine compounds having alkyl groups where one or more of the alkyl groups contains at least 8 carbon atoms. Such compounds may present improved hydrolytic stability, compared to other boroxine compounds. Such boroxine compounds may be used, for example, to improve seal compatibility in an engine. Other aspects of the invention are generally directed to systems and methods for making such boroxine compounds, engine oils containing such boroxine compounds, methods of using such boroxine compounds, or the like.

Abstract: A method of quantizing a floating point machine learning network to obtain a fixed point machine learning network using a quantizer may include selecting at least one moment of an input distribution of the floating point machine learning network. The method may also include determining quantizer parameters for quantizing values of the floating point machine learning network based at least in part on the at least one selected moment of the input distribution of the floating point machine learning network to obtain corresponding values of the fixed point machine learning network.

Abstract: An integrated stratigraphic method for determining total organic carbon (TOC) in a rock formation is provided, The method includes performing a geochemical analysis method to create a geochemical dataset; performing a chronostratigraphic method to create a chronostratigraphic dataset; performing a graphic correlation of the chronostratigaphic dataset from at least one location in the rock formation; determining a sequence stratigraphic model based on the graphic correlation; and generating a palaeogeographic reconstruction at one or more time periods by integrating the sequence stratigraphic model with the geochemical dataset to construct a predictive depositional model and determine a location and areal extent of total organic carbon within the rock formation.

Abstract: The present invention generally relates to compositions for use in lubricating oils. In certain aspects, the present invention is generally directed to boroxine compounds having alkyl groups where one or more of the alkyl groups contains at least 8 carbon atoms. Such compounds may present improved hydrolytic stability, compared to other boroxine compounds. Such boroxine compounds may be used, for example, to improve seal compatibility in an engine. Other aspects of the invention are generally directed to systems and methods for making such boroxine compounds, engine oils containing such boroxine compounds, methods of using such boroxine compounds, or the like.

Abstract: This invention relates to a container for storing an aqueous hydrogen peroxide solution, the container comprising: walls formed from a gas permeable, liquid impermeable polymeric material, the walls being capable of permitting gas to escape from the container through the walls to avoid build-up of pressure within the container while retaining liquid within the container, the polymeric material having a gas transmission rate in the range from about 0.05 to about 0.5 cubic centimeters of gas per square centimeter of polymeric material per 24 hours at 25° C.

Abstract: In some embodiments, a rebreathing oxygen supplementation device includes an enclosure including an internal surface of a size and shape to entirely cover the nasal region of a patient and including an edge region of a size and shape to reversibly mate with a skin region of the patient surrounding the nasal region. The device can include at least one tubular structure affixed to the enclosure, the tubular structure including a proximal region with a first aperture positioned adjacent to a nostril of the patient and at least one distal region with a second aperture, the tubular structure positioned to permit gas flow between an interior of the enclosure and a region exterior to the tubular structure, and an aperture in the proximal region positioned adjacent to the patient's nostrils.

Abstract: Methods and apparatus are provided for using a breakpoint determination unit to examine an artificial nervous system. One example method generally includes operating at least a portion of the artificial nervous system; using the breakpoint determination unit to detect that a condition exists based at least in part on monitoring one or more components in the artificial nervous system; and at least one of suspending, examining, modifying, or flagging the operation of the at least the portion of the artificial nervous system, based at least in part on the detection.