Abstract: A precision release agent management system for an electrostatographic reproduction apparatus fuser device. The precision release agent management system includes a reservoir adapted to contain a release agent. A wick absorbs release agent from the reservoir. A metering member receives release agent from the wick, which is supported for resiliently urging into operative contact with the metering member. A blade member is associated with the metering member to establish a desired thickness of release agent on the metering member, and a donor member is adapted to receive release agent from the metering member, and operatively contact the fuser device to apply the release agent thereto. A plurality of features is associated with the reservoir for precise alignment of the donor member, the metering member, and the metering blade.

Abstract: The present invention provides a method for detecting adverse reaction susceptibility and/or severity risk to an HMG CoA reductase inhibitor by determining the genotype of a CYP3A gene of a subject.

Abstract: A fireplace includes an outer enclosure having a front panel defining a front of the fireplace, and a combustion chamber enclosure defining a combustion chamber and including a front surface. The combustion chamber enclosure is positioned within the outer enclosure at a location spaced rearward from the front panel of the outer enclosure. The fireplace includes a glass panel secured to the front surface of the combustion chamber enclosure, and a surround member adapted and configured to be positioned between the front panel of the outer enclosure and the glass panel to cover the glass frame from view. Controls for the fireplace are positioned between the outer enclosure and the combustion chamber enclosure.

Abstract: A precision release agent management system for an electrostatographic reproduction apparatus fuser device. The precision release agent management system includes a reservoir adapted to contain a release agent. A wick absorbs release agent from the reservoir. A metering member receives release agent from the wick, which is supported for resiliently urging into operative contact with the metering member. A blade member is associated with the metering member to establish a desired thickness of release agent on the metering member, and a donor member is adapted to receive release agent from the metering member, and operatively contact the fuser device to apply the release agent thereto. A plurality of features is associated with the reservoir for precise alignment of he donor member, the metering member, and the metering blade.

Abstract: The present invention relates to improved methods for filling the skin for cosmetic or medical purposes. Compositions comprising carboxymethyl cellulose (CMC), polyethylene oxide (PEO) and calcium ions can be made and have physical properties that depend on the amounts and types of CMC, PEO, and calcium ions to form ioniclaly cross-linked gels. Compositions can be formed into microspheres, coascervates, gels, or membranes. Gels, microspheres and coascervates can be injected directly into a site for dermal filling. Membranes can be surgically introduced, where they swell to form hydrated gels. After introduction, the dermal filler persists for a period of time and then can disintegrate and be removed from the body.

Abstract: Provided are crosslinked polymer compositions that include a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has been modified to contain multiple nucleophilic groups, such as primary amino (—NH2) or thiol (—SH) groups. The second synthetic polymer may be a hydrophilic or hydrophobic synthetic polymer, which contains or has been derivatized to contain, two or more electrophilic groups, such as succinimidyl groups. The compositions may further include other components, such as naturally occurring polysaccharides or proteins (such as glycosaminoglycans or collagen) and/or biologically active agents.

Abstract: Carboxypolysaccharides (CPS) including carboxymethyl cellulose and their derivatives are provided that can be made into sponges, gels, membranes, particulates and other forms, for a variety of antiadhesion, antithrombogenic, drug delivery and/or hemostatic applications during surgery and pharmacological therapeutics. CPSs derivatized with primary amines can be used alone or in combination with poly(ethylene glycol) and poly(ethylene oxides) and other poly(alkylene oxides) to form materials having improved drug delivery, antiadhesion, and hemostatic uses. Applications include other types of chemical modifications of CPS to provide hydrogen, ionic, Van der Walls interactions and/or covalent bonding with drugs, biologicals and other therapeutic or diagnostic purposes.

Abstract: The invention provides recombinant procollagen chains having a natural collagen chain separated from one or two propeptide by one or two non-natural site-specific proteolytic agent (e.g., protease) recognition sites. A wide variety of propeptides and site-specific proteolytic agent recognition sites may be used: the selection of particular site-specific proteolytic agent/recognition site pairs is based on the conformation of the resulting procollagen, the availability of the site-specific proteolytic agent, the compatibility of the proteolysis with production of mature collagen, among other factors. Recombinant collagens chains are produced by contacting the subject recombinant procollagen chains with the appropriate site-specific proteolytic agents. Nucleic acids encoding the subject procollagen chains operably linked to transcription regulatory elements are used in vectors and cells for the production of recombinant collagen.

Abstract: An optically controlled mechanical device actuated by electrostatic forces. The device includes electrostatic plates disposed on opposing portions of the device to accumulate charge; conductors to conduct charge to the electrostatic plates from a bias supply; and a photoelectric element having a photoresistive element arranged to affect a quantity of charge reaching the electrostatic plates from the bias supply.

Abstract: Maintaining the linear velocity of an oil impregnated web oiler as the oil impregnated web is wound onto a driven take-up roll. When a new oil impregnated web is installed, the take-up roll is initially driven at an angular velocity to yield the predetermined optimum linear velocity of the oil impregnated web. The angular velocity of the take-up roll is decreased according to the algorithm of the invention so as to maintain constant the linear velocity of the oil impregnated web as the oil impregnated web is wound onto the take-up roll.

Abstract: The invention provides transgenic nonhuman mammals capable secreting exogenous procollagen or collagen into their milk. The mammals are healthy and capable of producing procollagen or collagen at high levels, usually in trimeric form. Suitable transgenes for incorporation into the mammals are also provided.

Abstract: Carboxypolysaccharides (CPS) including carboxymethyl cellulose and their derivatives are provided that can be made into sponges, gels, membranes, particulates and other forms, for a variety of antiadhesion, antithrombogenic, drug delivery and/or hemostatic applications during surgery and pharmacological therapeutics. CPSs derivatized with primary amines can be used alone or in combination with poly(ethylene glycol) and poly(ethylene oxides) and other poly(alkylene oxides) to form materials having improved drug delivery, antiadhesion, and hemostatic uses. Applications include other types of chemical modifications of CPS to provide hydrogen, ionic, Van der Walls interactions and/or covalent bonding with drugs, biologicals and other therapeutic or diagnostic purposes.

Abstract: The present invention is a device and system for manipulating a surgical tool at an intended location, e.g., a confined or inaccessible space, which includes a surgical anchor having at least one opening, wherein the opening provides a catch for a pin; and at least one anchor point to position and orient a surgical tool inside a human body. The apparatus and system of the present invention allows for the use of multiple intra-abdominal surgical tools inserted through a single incision.

Abstract: Provided are crosslinked polymer compositions that include a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has been modified to contain multiple nucleophilic groups, such as primary amino (—NH2) or thiol (—SH) groups. The second synthetic polymer may be a hydrophilic or hydrophobic synthetic polymer, which contains or has been derivatized to contain, two or more electrophilic groups, such as succinimidyl groups. The compositions may further include other components, such as naturally occurring polysaccharides or proteins (such as glycosaminoglycans or collagen) and/or biologically active agents.

Abstract: A variable torque device for maintaining constant tension in a web of material as the web is unwound from a supply roll. The variable torque device includes a lead screw attached to the shaft of the supply roll via an appropriate gear ratio. A coil spring is located between a hub on the lead screw and a set of rings and friction pads. As the lead screw rotates, the hub translates, thus changing the displacement of the coil spring, which in turn changes the loading of the rings and friction pads. With a full supply roll the coil spring is compressed so as to create an amount of torque to create the desired web tension. As the supply roll unwinds, the rotation of the lead screw translates the hub to expand the coil spring, reducing the torque and maintaining the web tension constant.

Abstract: Provided are crosslinked polymer compositions that include a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has been modified to contain multiple nucleophilic groups, such as primary amino (—NH2) or thiol (—SH) groups. The second synthetic polymer may be a hydrophilic or hydrophobic synthetic polymer, which contains or has been derivatized to contain, two or more electrophilic groups, such as succinimidyl groups. The compositions may further include other components, such as naturally occurring polysaccharides or proteins (such as glycosaminoglycans or collagen) and/or biologically active agents.

Abstract: A fireplace includes an outer enclosure having a front panel defining a front of the fireplace, and a combustion chamber enclosure defining a combustion chamber and including a front surface. The combustion chamber enclosure is positioned within the outer enclosure at a location spaced rearward from the front panel of the outer enclosure. The fireplace includes a glass panel secured to the front surface of the combustion chamber enclosure, and a surround member adapted and configured to be positioned between the front panel of the outer enclosure and the glass panel to cover the glass frame from view. Controls for the fireplace are positioned between the outer enclosure and the combustion chamber enclosure.

Abstract: The present invention is a method and apparatus for spraying makeup that masks imperfections in the skin including, but not limited to, freckles, tattoos, birthmarks, scars and post-laser surgery discoloration. The apparatus of the present invention is a hand-held sprayable cosmetic container containing a cosmetic composition that may be a foundation, a shimmer, a bronzer, a glitter, a self-tanning composition, a moisturizer, a toner, a lip color, an eyebrow color, a cheek color and/or an eye color. The apparatus may also be designed to deliver drugs (both prescription and over the counter medicines), deliver vitamins or other skin care compositions, to protect the skin from the sun, treat the skin after exposure to the sun, and/or provide an aromatherapy treatment.

Abstract: Provided are crosslinked polymer compositions that include a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has been modified to contain multiple nucleophilic groups, such as primary amino (—NH2) or thiol (—SH) groups. The second synthetic polymer may be a hydrophilic or hydrophobic synthetic polymer, which contains or has been derivatized to contain, two or more electrophilic groups, such as succinimidyl groups. The compositions may further include other components, such as naturally occurring polysaccharides or proteins (such as glycosaminoglycans or collagen) and/or biologically active agents.

Abstract: Crosslinked polymer compositions comprise a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has been modified to contain multiple nucleophilic groups, such as primary amino (—NH2)or thiol (—SH) groups. The second synthetic polymer may be a hydrophilic or hydrophobic synthetic polymer which contains, or has been derivatized to contain, two or more electrophilic groups, such as succinimidyl groups. The compositions may further comprise other components, such as naturally occurring polysaccharides or proteins (such as glycosaminoglycans or collagen) and/or biologically active agents.