Patents by Inventor Richard A. Calderone
Richard A. Calderone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9642846Abstract: The present invention relates to the administration of compounds of formula (I) for the treatment and/or prevention of fungal infections in subjects in need thereof. The methods of the invention also relates to the administration of pharmaceutical compositions comprising compounds of formula (I) for the treatment and/or prevention of fungal infections in subjects in need thereof. Subjects suffering from fungal infection and immunocompromised subjects may particularly benefit from the methods and compositions of the invention.Type: GrantFiled: March 14, 2014Date of Patent: May 9, 2017Assignee: Georgetown UniversityInventors: Richard A. Calderone, Nuo Sun
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Publication number: 20160038477Abstract: The present invention relates to the administration of compounds of formula (I) for the treatment and/or prevention of fungal infections in subjects in need thereof. The methods of the invention also relates to the administration of pharmaceutical compositions comprising compounds of formula (I) for the treatment and/or prevention of fungal infections in subjects in need thereof. Subjects suffering from fungal infection and immunocompromised subjects may particularly benefit from the methods and compositions of the invention.Type: ApplicationFiled: March 14, 2014Publication date: February 11, 2016Applicant: GEORGETOWN UNIVERSITYInventors: Richard A. Calderone, Nuo Sun
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Patent number: 9040715Abstract: Novel classes of 1,2-benzisothiazolinone and isoindolinone compounds and compositions are disclosed. These compounds and compositions are useful in treating, preventing, and/or ameliorating viral, yeast, and fungal infections such as, for example, Hepatitis C Virus, Flavivirus infections, Aspergillus fumigatus, and candidiasis.Type: GrantFiled: September 23, 2009Date of Patent: May 26, 2015Assignee: Georgetown UniversityInventors: Richard A. Calderone, William C. Groutas, Brent E. Korba
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Publication number: 20110251193Abstract: Novel classes of 1,2-benzisothiazolinone and isoindolinone compounds and compositions are disclosed. These compounds and compositions are useful in treating, preventing, and/or ameliorating viral, yeast, and fungal infections such as, for example, Hepatitis C Virus, Flavivirus infections, Aspergillus fumigatus, and candidiasis.Type: ApplicationFiled: September 23, 2009Publication date: October 13, 2011Applicants: WICHITA STATE UNIVERSITY, GEORGETOWN UNIVERSITYInventors: Richard A. Calderone, William C. Groutas, Brent E. Korba
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Publication number: 20110071072Abstract: Antifungal bone cement compositions and methods of using the same are disclosed. In one aspect, a bone cement composition comprises an echinocandin lipopeptide antifungal agent and a cementing agent. Optionally, the echinocandin lipopeptide antifungal agent is selected from the group consisting of micafungin, caspofungin and anidulafungin. The echinocandin lipopeptide antifungal agent is optionally micafungin. Methods of preventing a fungal infection following an arthroplasty procedure are also provided.Type: ApplicationFiled: August 26, 2010Publication date: March 24, 2011Applicant: Georgetown University, A Congressionally Chartered Institution of Higher EducationInventors: Richard A. Calderone, Michael O'Reilly
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Patent number: 6824992Abstract: The present invention relates to a histidine kinase, two-component gene (CaHK1) from Candida albicans. CaHK1 encodes a 2471 amino acid protein with an estimated molecular mass of 281.8 kDa. Also provided are vectors, host cells, antibodies and recombinant methods for producing the same. The invention further relates agonists and antagonists and to screening methods for identifying agonists and antagonists of CaHK1 polypeptide activity. The invention additionally relates to diagnostic methods for detecting CaHK1 nucleic acids, polypeptides, and antibodies in a biological sample. The present invention further relates to novel antagonists and vaccines for the prevention or attenuation of infection by Candida albicans.Type: GrantFiled: April 5, 2002Date of Patent: November 30, 2004Assignees: Human Genome Sciences, Inc., The Georgetown UniversityInventors: Antonio Jose C. Abad, Gil H. Choi, Richard A. Calderone
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Publication number: 20020146738Abstract: The present invention relates to a histidine kinase, two-component gene (CaHK1) from Candida albicans. CaHK1 encodes a 2471 amino acid protein with an estimated molecular mass of 281.8 kDa. Also provided are vectors, host cells, antibodies and recombinant methods for producing the same. The invention further relates agonists and antagonists and to screening methods for identifying agonists and antagonists of CaHK1 polypeptide activity. The invention additionally relates to diagnostic methods for detecting CaHK1 nucleic acids, polypeptides, and antibodies in a biological sample. The present invention further relates to novel antagonists and vaccines for the prevention or attenuation of infection by Candida albicans.Type: ApplicationFiled: April 5, 2002Publication date: October 10, 2002Applicant: Human Genome Sciences, Inc.Inventors: Antonio Jose C. Abad, Gil H. Choi, Richard A. Calderone
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Patent number: 6416989Abstract: The present invention relates to a histidine kinase, two-component gene (CaHK1) from Candida albicans. CaHK1 encodes a 2471 amino acid protein with an estimated molecular mass of 281.8 kDa. Also provided are vectors, host cells, antibodies and recombinant methods for producing the same. The invention further relates agonists and antagonists and to screening methods for identifying agonists and antagonists of CaHK1 polypeptide activity. The invention additionally relates to diagnostic methods for detecting CaHK1 nucleic acids, polypeptides, and antibodies in a biological sample. The present invention further relates to novel antagonists and vaccines for the prevention or attenuation of infection by Candida albicans.Type: GrantFiled: October 15, 1999Date of Patent: July 9, 2002Assignees: Human Genome Sciences, Inc., The Georgetown UniversityInventors: Antonio Jose C. Abad, Gil H. Choi, Richard A. Calderone
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Patent number: 6120999Abstract: The present invention relates to a histidine kinase, two-component gene (CaHK1) from Candida albicans. CaHK1 encodes a 2471 amino acid protein with an estimated molecular mass of 281.8 kDa. Also provided are vectors, host cells, antibodies and recombinant methods for producing the same. The invention further relates agonists and antagonists and to screening methods for identifying agonists and antagonists of CaHK1 polypeptide activity. The invention additionally relates to diagnostic methods for detecting CaHK1 nucleic acids, polypeptides, and antibodies in a biological sample. The present invention further relates to novel antagonists and vaccines for the prevention or attenuation of infection by Candida albicans.Type: GrantFiled: July 9, 1998Date of Patent: September 19, 2000Assignees: Human Genome Sciences, Inc., The Georgetown UniversityInventors: Antonio Jose C. Abad, Gil H. Choi, Richard A. Calderone