Patents by Inventor Richard A. Calderone

Richard A. Calderone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9642846
    Abstract: The present invention relates to the administration of compounds of formula (I) for the treatment and/or prevention of fungal infections in subjects in need thereof. The methods of the invention also relates to the administration of pharmaceutical compositions comprising compounds of formula (I) for the treatment and/or prevention of fungal infections in subjects in need thereof. Subjects suffering from fungal infection and immunocompromised subjects may particularly benefit from the methods and compositions of the invention.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: May 9, 2017
    Assignee: Georgetown University
    Inventors: Richard A. Calderone, Nuo Sun
  • Publication number: 20160038477
    Abstract: The present invention relates to the administration of compounds of formula (I) for the treatment and/or prevention of fungal infections in subjects in need thereof. The methods of the invention also relates to the administration of pharmaceutical compositions comprising compounds of formula (I) for the treatment and/or prevention of fungal infections in subjects in need thereof. Subjects suffering from fungal infection and immunocompromised subjects may particularly benefit from the methods and compositions of the invention.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 11, 2016
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Richard A. Calderone, Nuo Sun
  • Patent number: 9040715
    Abstract: Novel classes of 1,2-benzisothiazolinone and isoindolinone compounds and compositions are disclosed. These compounds and compositions are useful in treating, preventing, and/or ameliorating viral, yeast, and fungal infections such as, for example, Hepatitis C Virus, Flavivirus infections, Aspergillus fumigatus, and candidiasis.
    Type: Grant
    Filed: September 23, 2009
    Date of Patent: May 26, 2015
    Assignee: Georgetown University
    Inventors: Richard A. Calderone, William C. Groutas, Brent E. Korba
  • Publication number: 20110251193
    Abstract: Novel classes of 1,2-benzisothiazolinone and isoindolinone compounds and compositions are disclosed. These compounds and compositions are useful in treating, preventing, and/or ameliorating viral, yeast, and fungal infections such as, for example, Hepatitis C Virus, Flavivirus infections, Aspergillus fumigatus, and candidiasis.
    Type: Application
    Filed: September 23, 2009
    Publication date: October 13, 2011
    Applicants: WICHITA STATE UNIVERSITY, GEORGETOWN UNIVERSITY
    Inventors: Richard A. Calderone, William C. Groutas, Brent E. Korba
  • Publication number: 20110071072
    Abstract: Antifungal bone cement compositions and methods of using the same are disclosed. In one aspect, a bone cement composition comprises an echinocandin lipopeptide antifungal agent and a cementing agent. Optionally, the echinocandin lipopeptide antifungal agent is selected from the group consisting of micafungin, caspofungin and anidulafungin. The echinocandin lipopeptide antifungal agent is optionally micafungin. Methods of preventing a fungal infection following an arthroplasty procedure are also provided.
    Type: Application
    Filed: August 26, 2010
    Publication date: March 24, 2011
    Applicant: Georgetown University, A Congressionally Chartered Institution of Higher Education
    Inventors: Richard A. Calderone, Michael O'Reilly
  • Patent number: 6824992
    Abstract: The present invention relates to a histidine kinase, two-component gene (CaHK1) from Candida albicans. CaHK1 encodes a 2471 amino acid protein with an estimated molecular mass of 281.8 kDa. Also provided are vectors, host cells, antibodies and recombinant methods for producing the same. The invention further relates agonists and antagonists and to screening methods for identifying agonists and antagonists of CaHK1 polypeptide activity. The invention additionally relates to diagnostic methods for detecting CaHK1 nucleic acids, polypeptides, and antibodies in a biological sample. The present invention further relates to novel antagonists and vaccines for the prevention or attenuation of infection by Candida albicans.
    Type: Grant
    Filed: April 5, 2002
    Date of Patent: November 30, 2004
    Assignees: Human Genome Sciences, Inc., The Georgetown University
    Inventors: Antonio Jose C. Abad, Gil H. Choi, Richard A. Calderone
  • Publication number: 20020146738
    Abstract: The present invention relates to a histidine kinase, two-component gene (CaHK1) from Candida albicans. CaHK1 encodes a 2471 amino acid protein with an estimated molecular mass of 281.8 kDa. Also provided are vectors, host cells, antibodies and recombinant methods for producing the same. The invention further relates agonists and antagonists and to screening methods for identifying agonists and antagonists of CaHK1 polypeptide activity. The invention additionally relates to diagnostic methods for detecting CaHK1 nucleic acids, polypeptides, and antibodies in a biological sample. The present invention further relates to novel antagonists and vaccines for the prevention or attenuation of infection by Candida albicans.
    Type: Application
    Filed: April 5, 2002
    Publication date: October 10, 2002
    Applicant: Human Genome Sciences, Inc.
    Inventors: Antonio Jose C. Abad, Gil H. Choi, Richard A. Calderone
  • Patent number: 6416989
    Abstract: The present invention relates to a histidine kinase, two-component gene (CaHK1) from Candida albicans. CaHK1 encodes a 2471 amino acid protein with an estimated molecular mass of 281.8 kDa. Also provided are vectors, host cells, antibodies and recombinant methods for producing the same. The invention further relates agonists and antagonists and to screening methods for identifying agonists and antagonists of CaHK1 polypeptide activity. The invention additionally relates to diagnostic methods for detecting CaHK1 nucleic acids, polypeptides, and antibodies in a biological sample. The present invention further relates to novel antagonists and vaccines for the prevention or attenuation of infection by Candida albicans.
    Type: Grant
    Filed: October 15, 1999
    Date of Patent: July 9, 2002
    Assignees: Human Genome Sciences, Inc., The Georgetown University
    Inventors: Antonio Jose C. Abad, Gil H. Choi, Richard A. Calderone
  • Patent number: 6120999
    Abstract: The present invention relates to a histidine kinase, two-component gene (CaHK1) from Candida albicans. CaHK1 encodes a 2471 amino acid protein with an estimated molecular mass of 281.8 kDa. Also provided are vectors, host cells, antibodies and recombinant methods for producing the same. The invention further relates agonists and antagonists and to screening methods for identifying agonists and antagonists of CaHK1 polypeptide activity. The invention additionally relates to diagnostic methods for detecting CaHK1 nucleic acids, polypeptides, and antibodies in a biological sample. The present invention further relates to novel antagonists and vaccines for the prevention or attenuation of infection by Candida albicans.
    Type: Grant
    Filed: July 9, 1998
    Date of Patent: September 19, 2000
    Assignees: Human Genome Sciences, Inc., The Georgetown University
    Inventors: Antonio Jose C. Abad, Gil H. Choi, Richard A. Calderone