Abstract: Systems and methods are provided to monitor a user body position and/or influence a user to change and improve body position, without causing the user to wake up. A personal audio output communicator is adapted to be positioned in close proximity to an ear of the user. A motion detector is adapted to attach to the user for generating a motion signal. A stimulus provider is adapted to receive the motion signal from the motion detector and to compare a motion signal value representative of the motion signal to a preset motion value. In response to the comparison, the stimulus provider transmits a user-selected stimulus and/or voice command stimulus to the personal audio output communicator.

Abstract: A system and method for detection of alpha particles generated by a test material in proximity to a light atomic weight element. The system includes a neutron detector that is configured to detect a rate of generation of neutrons produced by an (alpha, n) reaction between the test material and the light atomic weight element. There is also at least one gamma-ray detector configured to measure a rate of generation of 511 keV gamma rays produced by an annihilation reaction triggered by a positron emission from a daughter product of the light atomic weight element. A comparator is configured to compare the rate of generation of neutrons and the rate of generation of 511 keV gamma rays.

Abstract: A system and method for detection of alpha particles generated by a test material in proximity to a light atomic weight element. The system includes a neutron detector that is configured to detect a rate of generation of neutrons produced by an (alpha, n) reaction between the test material and the light atomic weight element. There is also at least one gamma-ray detector configured to measure a rate of generation of 511 keV gamma rays produced by an annihilation reaction triggered by a positron emission from a daughter product of the light atomic weight element. A comparator is configured to compare the rate of generation of neutrons and the rate of generation of 511 keV gamma rays.

Abstract: A low-cost infra-red detector is disclosed including a method of making and using the same. The detector employs a substrate, a filtering layer, a converting layer, and a diverter to be responsive to wavelengths up to about 1600 nm. The detector is useful for a variety of applications including spectroscopy, imaging, and defect detection.

Abstract: Compounds having the formula are useful for treating conditions which arise from or are exacerbated by angiogenesis. Also disclosed are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating cancer.

Abstract: Compounds having the formula are methionine aminopeptidase type 2 (MetAP2) inhibitors and are useful for inhibiting angiogenesis. Also disclosed are MetAP2-inhibiting compositions and methods of inhibiting angiogenesis in a mammal.

Abstract: Compounds having Formula I or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of inhibiting angiogenesis in a mammal.

Abstract: Compounds having the formula 1

Abstract: Compounds having the formula 1

Abstract: Compounds having Formula I 1

Abstract: A non-destructive method for quantifying the hydrogen content or a hydrogen-bearing constituent in a material is based on the principle of moderating neutron spectroscopy. This technique is particularly suited for analyzing materials containing the high scattering/capture cross-section element of hydrogen. The method involves exposing a neutron moderator to a beam of radiation comprising neutrons and measuring thermal neutron intensities at a plurality of locations in the moderator. These measured intensities reflect the energy distribution of the beam of radiation incident upon the moderator. Thus, by measuring these intensities with the material present, and comparing these intensities to a model, to those of a composition standard(s), or combinations thereof, the hydrogen content of the material is quantified. Furthermore, the hydrogen-bearing constituent of the material is quantified by knowing or estimating the chemical or molecular structure of the material.

Abstract: Compounds having Formula I or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of inhibiting angiogenesis in a mammal.

Abstract: A method and apparatus for increasing the quantum efficiency of a photomultiplier tube by providing a photocathode with an increased surface-to-volume ratio. The photocathode includes a transparent substrate, upon one major side of which is formed one or more large aspect-ratio structures, such as needles, cones, fibers, prisms, or pyramids. The large aspect-ratio structures are at least partially composed of a photoelectron emitting material, i.e., a material that emits a photoelectron upon absorption of an optical photon. The large aspect-ratio structures may be substantially composed of the photoelectron emitting material (i.e., formed as such upon the surface of a relatively flat substrate) or be only partially composed of a photoelectron emitting material (i.e., the photoelectron emitting material is coated over large aspect-ratio structures formed from the substrate material itself.

Abstract: A non-destructive method for quantifying the hydrogen content or a hydrogen-bearing constituent in a material is disclosed. The method is based on the principle of moderating neutron spectroscopy which is particularly suited for analyzing materials containing the high scattering/capture cross-section element of hydrogen. The method comprises the steps of exposing a neutron moderator to a beam of radiation comprising neutrons and measuring thermal neutron intensities at a plurality of locations in the moderator. These measured intensities reflect the energy distribution of the beam of radiation incident upon the moderator. Thus, by measuring these intensities with the material present, and comparing these intensities to a model, to those of a composition standard(s), or combinations thereof, the hydrogen content of the material is quantified. Furthermore, the hydrogen-bearing constituent of the material is quantified by knowing or estimating the chemical or molecular structure of the material.

Abstract: A non-destructive method for quantifying the hydrogen content or a hydrogen-bearing constituent in a material. Moderating neutron spectroscopy is particularly suited for analyzing materials containing the high scattering/capture cross-section element of hydrogen. A neutron moderator is exposed to a beam of neutron radiation and the thermal neutron intensities at a number of locations in the moderator are then measured. The measured intensities reflect the energy distribution of the radiation beam incident upon the moderator. By measuring intensities with the material present and comparing the intensities to a model, or to those of a composition standard(s), the hydrogen content of the material is quantified. The hydrogen-bearing constituent of the material may be further quantified by knowing or estimating the chemical or molecular structure of the material.

Abstract: The present invention is an apparatus for detecting ionizing radiation, having: a waveguide having a first end and a second end, the waveguide formed of a scintillator material wherein the therapeutic ionizing radiation isotropically generates scintillation light signals within the waveguide. This apparatus provides a measure of radiation dose. The apparatus may be modified to permit making a measure of location of radiation dose. Specifically, the scintillation material is segmented into a plurality of segments; and a connecting cable for each of the plurality of segments is used for conducting scintillation signals to a scintillation detector.

Abstract: A method and apparatus for increasing the quantum efficiency of a photomultiplier tube by providing a photocathode with an increased surface-to-volume ratio. The photocathode includes a transparent substrate, upon one major side of which is formed one or more large aspect-ratio structures, such as needles, cones, fibers, prisms, or pyramids. The large aspect-ratio structures are at least partially composed of a photoelectron emitting material, i.e., a material that emits a photoelectron upon absorption of an optical photon. The large aspect-ratio structures may be substantially composed of the photoelectron emitting material (i.e., formed as such upon the surface of a relatively flat substrate) or be only partially composed of a photoelectron emitting material (i.e., the photoelectron emitting material is coated over large aspect-ratio structures formed from the substrate material itself.

Abstract: 3-Substituted indole carbohydrazides having the formula 1

Abstract: Compounds having the formula 1

Abstract: An improved method and apparatus for the detection of hydrogenated materials. Detection of concealed hydrogenated materials such as organic explosives, drugs, or biological tissue is accomplished by measuring the backscattering of neutrons from hydrogenous material in the targeted environment. The system comprises a neutron source that provides information as to the time at which the neutron is emitted, and a neutron sensor, which provides information as to the time at which the neutron is detected and may provide information as to the location at which the neutron is detected. The invention comprises a timing circuit that deactivates the neutron sensor during a time delay to reject signals from neutrons that have not scattered from hydrogen nuclei. The invention may further cease to detect neutrons after a window to reject signals from neutrons that have scattered off distant hydrogen nuclei, which may represent background noise.