Patents by Inventor Richard A. Dluhy

Richard A. Dluhy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SURFACE ENHANCED RAMAN SPECTROSCOPY PLATFORMS AND METHODS
    Publication number: 20120208722
    Abstract: Surface enhanced Raman spectroscopy (SERS) platforms and methods of making and using such platforms are disclosed herein. Such platforms can be made by immobilizing a biomaterial (e.g., a carbohydrate such as a glycan) by reacting an azide-functional group attached to a surface of a solid substrate with at least one cyclooctyne (e.g., a dibenzocyclooctyne) having a biomaterial or biomaterial binding group attached thereto. In certain embodiments the immobilized biomaterial can be detected using, for example, surface enhanced Raman spectroscopy.
    Type: Application
    Filed: October 19, 2011
    Publication date: August 16, 2012
    Inventors: RICHARD DLUHY, GEERT-JAN BOONS, SHARON MARTIN, Jun Guo, Xiuru Li
  • Surface enhanced Raman spectroscopy (SERS) systems for the detection of viruses and methods of use thereof
    Patent number: 7940387
    Abstract: Surface-enhanced Raman spectroscopic (SERS) systems and methods for detecting and differentiating biomolecules of interest, such as human immunodeficiency virus (HIV), are provided.
    Type: Grant
    Filed: June 9, 2008
    Date of Patent: May 10, 2011
    Assignee: Univeristy of Georgia Research Foundation, Inc.
    Inventors: Richard A. Dluhy, Ralph A. Tripp, Yiping Zhao, Jeremy Driskell
  • Surface enhanced Raman spectroscopy (SERS) systems for the detection of bacteria and methods of use thereof
    Patent number: 7889334
    Abstract: Surface-enhanced Raman spectroscopic (SERS) systems and methods for detecting biomolecules of interest, such as a bacterium or virus are provided.
    Type: Grant
    Filed: June 16, 2008
    Date of Patent: February 15, 2011
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Duncan C. Krause, Suzanne Marie Larkin Hennigan, Richard A. Dluhy, Jeremy Driskell, Yiping Zhao, Ralph A. Tripp
  • Methods of use for surface enhanced raman spectroscopy (SERS) systems for the detection of bacteria
    Patent number: 7880876
    Abstract: Surface-enhanced Raman spectroscopic (SERS) systems and methods for detecting biomolecules of interest, such as a bacterium are provided.
    Type: Grant
    Filed: July 2, 2008
    Date of Patent: February 1, 2011
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Yiping Zhao, Richard A. Dluhy, Ralph A. Tripp, Yao-wen Huang, Hsiao Yun Chu, Yongjun Liu
  • METHODS, DEVICES, AND COMPOSITIONS FOR THE HIGHLY-SENSITIVE DETECTION AND IDENTIFICATION OF DIVERSE MOLECULAR ENTITIES
    Publication number: 20100268473
    Abstract: Embodiments of the present disclosure include a method for analysis of individual components in a multicomponent sample where the identity of the individual components is an indicator for disease.
    Type: Application
    Filed: February 19, 2009
    Publication date: October 21, 2010
    Inventors: Ralph A. Tripp, Richard A. Dluhy, Yiping Zhao, Jeremy Driskell
  • Surface enhanced Raman spectroscopy (SERS) systems, substrates, fabrication thereof, and methods of use thereof
    Patent number: 7738096
    Abstract: Surface-enhanced Raman spectroscopic (SERS) systems including nanostructures and capable of detecting analytes, in particular biomolecules, of interest are provided. Methods of making the SERS systems and methods for detection of a biomolecule of interest, such as a virus or other infectious agent are also provided.
    Type: Grant
    Filed: March 15, 2006
    Date of Patent: June 15, 2010
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Yiping Zhao, Richard A. Dluhy, Ralph A. Tripp, Stephen Chaney, Saratchandra Shanmukh
  • METHODS OF USE FOR SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS) SYSTEMS FOR THE DETECTION OF BACTERIA
    Publication number: 20090303472
    Abstract: Surface-enhanced Raman spectroscopic (SERS) systems and methods for detecting biomolecules of interest, such as a bacterium are provided.
    Type: Application
    Filed: July 2, 2008
    Publication date: December 10, 2009
    Inventors: Yiping Zhao, Richard A. Dluhy, Ralph A. Tripp, Yao-wen Huang, Hsiao Yun Chu, Yongjun Liu
  • Surface enhanced raman spectroscopy (SERS) systems and methods of use thereof
    Patent number: 7583379
    Abstract: Surface-enhanced Raman spectroscopic (SERS) systems and methods for detecting biomolecules of interest, such as a virus, bacterium, or other infectious agent, are provided. A spectroscopic assay based on surface enhanced Raman scattering (SERS) using a silver nanorod array substrate fabricated by oblique angle deposition has been developed that allows for rapid detection of trace levels of viruses or bacteria with a high degree of sensitivity and specificity. This novel and improved SERS assay can detect minor spectral differences within strains of a single virus type such as respiratory syncytial virus or influenza virus in the presence of biological media. The method provides rapid diagnostics for direct molecular and structural characterization of virus strains and virus gene deletion mutants generating reproducible viral spectra without viral manipulation.
    Type: Grant
    Filed: July 28, 2006
    Date of Patent: September 1, 2009
    Assignee: University of Georgia Research Foundation
    Inventors: Yiping Zhao, Richard A. Dluhy, Ralph A. Tripp, Stephen Chaney, Sarat Shanmukh, Leslie P. Jones
  • SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS) SYSTEMS AND METHODS OF USE THEREOF
    Publication number: 20090149344
    Abstract: Surface-enhanced Raman spectroscopic (SERS) systems and methods for detecting biomolecules of interest, such as a virus, bacterium, or other infectious agent, are provided. A spectroscopic assay based on surface enhanced Raman scattering (SERS) using a silver nanorod array substrate fabricated by oblique angle deposition has been developed that allows for rapid detection of trace levels of viruses or bacteria with a high degree of sensitivity and specificity. This novel and improved SERS assay can detect minor spectral differences within strains of a single virus type such as respiratory syncytial virus or influenza virus in the presence of biological media. The method provides rapid diagnostics for direct molecular and structural characterization of virus strains and virus gene deletion mutants generating reproducible viral spectra without viral manipulation.
    Type: Application
    Filed: July 28, 2006
    Publication date: June 11, 2009
    Inventors: Yiping Zhao, Richard A. Dluhy, Ralph A. Tripp, Stephen Chaney, Sarat Shanmukh, Leslie P. Jones
  • Surface Enhanced Raman Spectroscopy (SERS) systems for the detection of viruses and methods of use thereof
    Publication number: 20090086201
    Abstract: Surface-enhanced Raman spectroscopic (SERS) systems and methods for detecting and differentiating biomolecules of interest, such as human immunodeficiency virus (HIV), are provided.
    Type: Application
    Filed: June 9, 2008
    Publication date: April 2, 2009
    Inventors: Richard A. Dluhy, Ralph A. Tripp, Yiping Zhao, Jeremy Driskell
  • Surface enhanced Raman spectroscopy (SERS) systems for the detection of bacteria and methods of use thereof
    Publication number: 20090082220
    Abstract: Surface-enhanced Raman spectroscopic (SERS) systems and methods for detecting biomolecules of interest, such as a bacterium or virus are provided.
    Type: Application
    Filed: June 16, 2008
    Publication date: March 26, 2009
    Inventors: Duncan C. Krause, Suzanne Marie Larkin Hennigan, Richard A. Dluhy, Jeremy Driskell, Yiping Zhao, Ralph A. Tripp
  • Surface enhanced Raman spectroscopy (SERS) systems, substrates, fabrication thereof, and methods of use thereof
    Publication number: 20060252065
    Abstract: Surface-enhanced Raman spectroscopic (SERS) systems including nanostructures and capable of detecting analytes, in particular biomolecules, of interest are provided. Methods of making the SERS systems and methods for detection of a biomolecule of interest, such as a virus or other infectious agent are also provided.
    Type: Application
    Filed: March 15, 2006
    Publication date: November 9, 2006
    Inventors: Yiping Zhao, Richard Dluhy, Ralph Tripp, Stephen Chaney, Saratchandra Shanmukh