Abstract: The present invention relates to the preparation of insulinotropic peptides that are synthesized using a solid and solution phase (“hybrid”) approach. Generally, the approach includes synthesizing three different peptide intermediate fragments using solid phase chemistry. Solution phase chemistry is then used to add additional amino acid material to one of the fragments. The fragments are then coupled together in the solution phase. The use of a pseudoproline in one of the fragments eases solid phase synthesis of that fragment and also eases subsequent solution phase coupling of this fragment to other fragments. The present invention is very useful for forming insulinotropic peptides such as Exenatide(1-39) and its natural and non-natural counterparts.

Abstract: The present invention relates to the preparation of insulinotropic peptides that are synthesized using a solid and solution phase (“hybrid”) approach. Generally, the approach includes synthesizing three different peptide intermediate fragments using solid phase chemistry. Solution phase chemistry is then used to add additional amino acid material to one of the fragments. The fragments are then coupled together in the solution phase. The use of a pseudoproline in one of the fragments eases solid phase synthesis of that fragment and also eases subsequent solution phase coupling of this fragment to other fragments. The present invention is very useful for forming insulinotropic peptides such as Exenatide(1-39) and its natural and non-natural counterparts.

Abstract: The present invention relates to technology for preparing derivatives of unsaturated, cyclic, organic acids and salts, thereof. Shikimic acid is an example of such an acid. More particularly, the present invention relates to preparing derivatives of these acids or salts thereof that are esterified, ketalized, functionalized with a leaving group, and/or provided with epoxide functionality. Preferred aspects may be used in the synthesis of Oseltamivir Phosphate starting from shikimic acid.

Abstract: The present invention relates to technology for preparing derivatives of unsaturated, cyclic, organic acids and salts, thereof. Shikimic acid is an example of such an acid. More particularly, the present invention relates to preparing derivatives of these acids or salts thereof that are esterified, ketalized, functionalized with a leaving group, and/or provided with epoxide functionality. Preferred aspects may be used in the synthesis of Oseltamivir Phosphate starting from shikimic acid.

Abstract: A continuous motion cylindrical can decorator is provided with mandrels that receive undecorated cans and a deco chain that carries decorated cans through a curing oven. The mandrels are mounted along the periphery of a continuously rotating carrier. Chain speed is much slower than linear mandrel speed and spacing between pins on the chain is much less than spacing between mandrels. Interposed between the chain and the mandrel carrier is a continuously rotating transfer carrier having a plurality of suction holding devices thereto. As the holding devices move through a transfer region they are in single file and receive cans that are blown from the mandrels. In the transfer region mandrel linear speed is substantially greater than linear speed of the holding devices, and spacing between the latter is much less than spacing between mandrels As the loaded suction holding devices move downstream through a pickup region cans thereon are loaded on two rows of pins carried by the deco chain.

Abstract: A continuous motion cylindrical can decorator is provided with mandrels that receive undecorated cans and a deco chain that carries decorated cans through a curing oven. The mandrels are mounted along the periphery of a continuously rotating carrier. Chain speed is much slower than linear mandrel speed and spacing between pins on the chain is much less than spacing between mandrels. Interposed between the chain and the mandrel carrier is a continuously rotating transfer carrier having a plurality of suction holding devices thereto. As the holding devices move through a transfer region they are in single file and receive cans that are blown from the mandrels. In the transfer region mandrel linear speed is substantially greater than linear speed of the holding devices, and spacing between the latter is much less than spacing between the mandrels.

Abstract: An X-ray tubehead counterbalancing mechanism devoid of springs, cams and chains is disclosed. The mechanism requires only a single adjustment to precisely counterbalance objects, such as tubeheads and the like. The mechanism includes a commercially available gas spring which is used in conjunction with parallel motion linkage assembly which carries the tubehead. The piston rod end of the gas spring is adjustable upwardly or downwardly in a direction substantially normal to the axis of the piston rod by means of a single adjustment screw cooperating with a clevis which pivotally mounts the piston rod. With such adjustment capability, the present mechanism will support and counterbalance tubeheads having wide variations in weight and inertia.