Abstract: Fluorescent energy transfer cassettes that allow through bond energy transfer and have a succinimidyl ester functionality suitable for affecting them to biomolecules or provided and are applied to high throughput DNA sequencing.

Abstract: A method and system interface a digital data stream having at least one telephony data set with a telephony network, such as a single twisted wire pair telephony network installed in a residence or business. The telephony data set is converted to a telephony signal for use by conventional telephony devices, such as telephones, and is transmitted through the telephony network in a telephony network band. The telephony network band can be located outside of the voiceband to avoid interference with central office signals. Plural data telephony data sets can each provide a telephony signal directed to one or more telephony devices associated with the telephony network. Telephone control modules interfaced associated with the telephony devices can translate telephony signals from the telephony network band to the voiceband for use by the associated telephony devices. The method and system can support plural simultaneous telephony communications through a single twisted pair or other telephony network.

Abstract: Fluorescent energy transfer cassettes that allow through bond energy transfer and have a succinimidyl ester functionality suitable for affecting them to biomolecules or provided and are applied to high throughput DNA sequencing.

Abstract: The use of BODIPY.RTM. fluorophores for detecting a target nucleic acid is described. The parent heterocyclic molecule of the BODIPY.RTM. fluorophores is a dipyrrometheneboron difluoride compound which is modified to create a broad class of spectrally-discriminating fluorophores. The present invention provides oligonucleotides labelled with substituted 4,4-difluoro-4-bora-3A,4A-diaza-s-indacene (BODIPY.RTM. fluorophore) compounds for performing the Taqman assay.

Abstract: Methods for the use of a class of dyes for improved DNA sequencing are provided. A new class of dyes, BODIPY.RTM. fluorophores, has been described recently. The parent heterocyclic molecule of the BODIPY.RTM. fluorophores is a dipyrrometheneboron difluoride compound which is modified to create a broad class of spectrally-discriminating fluorophores. The present invention provides methods for the use of BODIPY.RTM. fluorophore-labeled DNA for dye-primer sequencing in which the BODIPY.RTM.s are attached to the 5' end of sequencing primers. BODIPY.RTM. fluorophores have improved spectral characteristics compared to conventional fluorescein and rhodamine dyes. BODIPY.RTM. fluorophores have narrower band width, insensitivity to solvent or pH, and improved photostability, thus, BODIPY.RTM. fluorophores lead to improved DNA sequencing and/or detection in any method where electrophoresis and detection of DNA is required. Additionally, the spectral properties of the BODIPY.RTM.

Abstract: Methods for the use of a class of dyes for improved DNA sequencing by the chain termination method of DNA sequencing, and internal labelling of polynucleotides by enzymatic incorporation of fluorescently-labeled ribonucleotides or deoxyribonucleotides are provided. A new class of dyes, BODIPY.RTM. fluorophores, has been described recently. The parent heterocyclic molecule of the BODIPY.RTM. fluorophores is a dipyrrometheneboron difluoride compound which is modified to create a broad class of spectrally-discriminating fluorophores. BODIPY.RTM. fluorophores have improved spectral characteristics compared to conventional fluorescein and rhodamine dyes. BODIPY.RTM. fluorophores have narrower band width, insensitivity to solvent or pH, and improved photostability, thus, BODIPY.RTM. fluorophores lead to improved DNA sequencing and/or detection in any method where electrophoresis and detection of DNA is required. Additionally, the spectral properties of the BODIPY.RTM.

Abstract: Methods for the use of a class of dyes for improved DNA sequencing are provided. A new class of dyes, BODIPY.RTM. fluorophore, has been described recently. The parent heterocyclic molecule of the BODIPY.RTM. fluorophore is a dipyrrometheneboron difluoride compound which is modified to create a broad class of spectrally-discriminating fluorophores. The present invention provides methods for the use of BODIPY.RTM. fluorophore-labeled DNA. BODIPY.RTM. fluorophore have improved spectral characteristics compared to conventional fluorescein and rhodamine dyes. BODIPY.RTM. fluorophore have narrower band width, insensitivity to solvent or pH, and improved photostability, thus, BODIPY.RTM. fluorophores lead to improved DNA sequencing and/or detection in any method where electrophoresis and detection of DNA is required. Additionally, the spectral properties of the BODIPY.RTM. fluorophores are sufficiently similar in wavelength and intensity to be used with conventional equipment known in the art.

Abstract: In an automatic call distribution (ACD) system having a controller function, a primary system controller and a redundant system controller wherein the secondary system controller is in active operation and the primary system controller is out of synchronization with the redundant system controller, a method is provided for resynchronizing the primary system controller to the redundant system controller wherein selected database update functionality of the redundant system controller is suspended and database files and shared memory are copied in phases from the redundant system controller to the primary system controller with the means provided to continue to do data collection, call answering and queuing of calls, except for a brief period immediately preceding resynchronization.

Abstract: A hapten is described which may be used to elicit antibodies that catalyze the deamidation of asparginyl-glycyl dipeptides to form two products, the isoaspartyl-glycyl dipeptide and the aspartyl-glycyl dipeptide. A general synthetic scheme is also presented which shows how to modify the hapten to provide specificity for a particular protein in the antibodies that are elicited by the (modified) hapten. Antibodies which catalyze the the deamidation reaction are also described.

Abstract: The present invention relates to a handle for a suitcase, which has a bottom surface, a top surface, and at least four sides where a first and second sides oppose one another and a third and fourth sides oppose one another. The suitcase further includes a plurality of wheels disposed on the bottom surface to provide transitional movement of the suitcase when the suitcase is pivoted about the plurality of wheels and placed in an inclined position.The handle comprising a first and second straps each having a first and second ends, the first and second straps being coupled to opposite sides of the suitcase.

Abstract: The present invention provides a unique ventilated fabric cover reinforced at selected portions for protecting finishes of stringed instruments. In a presently preferred embodiment, the inventive fabric cover is composed of interlaced, natural fibers woven or knitted in a prescribed ventilated pattern, and reinforced at selective portions which are more subject to wear as the instrument is played over time. The ventilated fabric is configured to protect and surround the outer rear peripheral portion of the stringed instrument, and may be custom sized for a wide variety of guitars, violins, violas, lutes, stringed basses, cellos, or the like. The unique cover further comprises elastic banding disposed in a central portion of the fabric to effect a tensioned form fit with the outer rear peripheral portion of the instrument to be protected.