Patents by Inventor Richard A. Hodin

Richard A. Hodin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INTESTINAL ALKALINE PHOSPHATASES AND METHODS OF USE IN INHIBITING LIVER FIBROSIS
    Publication number: 20230302098
    Abstract: The present disclosure relates, inter alia, to therapeutic alkaline phosphatases for the treatment of liver fibrosis.
    Type: Application
    Filed: July 29, 2021
    Publication date: September 28, 2023
    Inventor: Richard A. Hodin
  • TARGETING THE GASTROINTESTINAL BARRIER TO TREAT AGE-RELATED DISORDERS
    Publication number: 20220273773
    Abstract: The disclosure provides various aspects and embodiments of methods of, and compositions for use in methods of, treating age-related physiological alterations (e.g., those associated with age-related diseases or disorders) and/or treating or delaying the onset of age-related frailty in a subject. The methods include administering an AP-based agent or composition (e.g., a bovine intestinal alkaline phosphatase).
    Type: Application
    Filed: July 30, 2020
    Publication date: September 1, 2022
    Inventor: Richard A. Hodin
  • Methods of Modulating Gastrointestinal Tract Flora Levels with Alkaline Phosphatase
    Publication number: 20170252327
    Abstract: This invention relates generally to a therapeutic use of alkaline phosphatase to modulate gastrointestinal tract flora levels in subject.
    Type: Application
    Filed: May 19, 2017
    Publication date: September 7, 2017
    Inventors: Richard A. Hodin, Madhu S. Malo
  • Methods of reducing or inhibiting toxic effects associated with a bacterial infection using alkaline phosphatase
    Patent number: 8932587
    Abstract: This invention relates generally to a therapeutic use of alkaline phosphatase to reduce or inhibit toxic effects associated with a bacterial infection in a subject.
    Type: Grant
    Filed: February 11, 2011
    Date of Patent: January 13, 2015
    Assignee: The General Hospital Corporation
    Inventors: Richard A. Hodin, Madhu S. Malo
  • Methods of Reducing or Inhibiting Toxic Effects Associated with a Bacterial Infection Using Alkaline Phosphatase
    Publication number: 20130022591
    Abstract: This invention relates generally to a therapeutic use of alkaline phosphatase to reduce or inhibit toxic effects associated with a bacterial infection in a subject.
    Type: Application
    Filed: February 11, 2011
    Publication date: January 24, 2013
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Richard A. Hodin, Madhu S. Malo
  • Methods of Modulating Gastrointestinal Tract Flora Levels with Alkaline Phosphatase
    Publication number: 20110206654
    Abstract: This invention relates generally to a therapeutic use of alkaline phosphatase to modulate gastrointestinal tract flora levels in subject.
    Type: Application
    Filed: August 27, 2009
    Publication date: August 25, 2011
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Richard A. Hodin, Madhu S. Malo
  • DNA encoding a pituitary-specific thyroid hormone receptor
    Patent number: 5284999
    Abstract: The invention relates to the purification and cloning of a receptor for thyroid hormone. The receptor is designated PSTHR and is related to hormone receptors encoded by the genes erbA.alpha.-1, erbaA.alpha.-2 and erbA.beta.-1. The gene encoding PSTHR, erbA.beta.-2, is partially homologous to the erbA.beta.-1. However, PSTHR differs from the product of erbA.beta.-1 in that its expression is limited to the anterior pituitary gland. The invention additionally concerns the uses for PSTHR in the diagnosis and therapy of human conditions.
    Type: Grant
    Filed: May 13, 1993
    Date of Patent: February 8, 1994
    Assignee: Brigham and Women's Hospital
    Inventors: William W. Chin, Richard A. Hodin, Mitchell A. Lazar