Patents by Inventor Richard A. Holl
Richard A. Holl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240115490Abstract: The invention relates to a drug delivery system for contraception including a steroidal estrogenic compound, a steroidal progestogenic compound or a combination thereof for the purposes of contraception in a subject, and provides for an ultra-low dose delivery of a steroidal estrogenic compound which minimizes or eliminates a burst release effect. The invention also relates to a method of contraception using the drug delivery system and method of manufacturing the drug delivery system.Type: ApplicationFiled: December 20, 2023Publication date: April 11, 2024Inventors: Vinita GUPTA, Richard HOLL, James GAREGNANI, Gregory KAUFMAN
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Publication number: 20230404911Abstract: The invention relates to a drug delivery system for contraception including a steroidal estrogenic compound, a steroidal progestogenic compound or a combination thereof for the purposes of contraception in a subject, and provides for an ultra-low dose delivery of a steroidal estrogenic compound which minimizes or eliminates a burst release effect. The invention also relates to a method of contraception using the drug delivery system and method of manufacturing the drug delivery system.Type: ApplicationFiled: August 30, 2023Publication date: December 21, 2023Inventors: Vinita GUPTA, Richard HOLL, James GAREGNANI, Gregory KAUFMAN
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Publication number: 20230079420Abstract: The invention described herein provides new combination products for the cyclical provision of a methylcobalamin compound and a steroid compound in a dosing regimen wherein the total amount of methylcobalamin administered during any one treatment cycle does not exceed 35 mcg. More specifically, the combination products described in this disclosure promote the prevention or treatment of a vitamin B12 deficiency, support the replenishment and or maintenance of healthy blood cell levels, or both, particularly in those experiencing a periodic physiological challenge which may compromise vitamin B12 status or result in an increased requirement for vitamin B12, such as the monthly blood loss experienced by a reproductively cycling human female.Type: ApplicationFiled: October 13, 2022Publication date: March 16, 2023Inventors: James A Garegnani, Richard Holl, Gregory Kaufman
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Patent number: 11602522Abstract: Method of treating sexually transmitted infection in a subject in need thereof involving administering to the subject a therapeutically effective amount of secnidazole in a microgranule formulation, wherein the microgranule formulation comprises a plurality of microgranules having a volume-weighted particle size distribution within a microgranule population, wherein the volume-weighted particle size distribution as measured from a representative sample of the microgranule population comprises (a) 10% of the microgranule population having a volume-weighted particle size about no less than 470 micrometers; (b) 50% of the microgranule population having a volume-weighted particle size between about no less than 640 micrometers and about no more than 810 micrometers; (c) 90% of the microgranule population having a volume-weighted particle size about no more than 1170 micrometers; or (d) a combination thereof, which can include some or all of (a) through (c) above.Type: GrantFiled: May 7, 2021Date of Patent: March 14, 2023Assignee: LUPIN INC.Inventors: Helen S. Pentikis, David Palling, Carol J. Braun, Richard Holl
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Patent number: 11478503Abstract: The invention described herein provides new methods and compositions for the cyclical provision of a vitamin B12 compound in a dosing regimen wherein the total amount of vitamin B12 administered during any one treatment cycle does not exceed 35 mcg. More specifically, the invention described in this disclosure promotes the prevention or treatment of a vitamin B12 deficiency, supports the replenishment and or maintenance of healthy blood cell levels, or both, particularly in those experiencing a periodic physiological challenge which may compromise vitamin B12 status or result in an increased requirement for vitamin B12, such as the monthly blood loss experienced by a reproductively cycling human female.Type: GrantFiled: November 18, 2020Date of Patent: October 25, 2022Assignee: Lupin, Inc.Inventors: James A Garegnani, Richard Holl, Gregory Kaufman
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Patent number: 11400093Abstract: New deuterated analogs of elagolix are provided. The novel deuterated elagolix analogs differ from the only previously disclosed deuterated elagolix analogs in structure based on the exclusion of deuterium at certain sites in the compounds and the inclusion of deuterium at other sites. Also provided are new formulations for deuterated elagolix compounds and methods of using such compounds and formulations in the modification of mammalian physiology and especially in the treatment and prevention of a number of diseases and disorders, including endometriosis-associated pain and uterine fibroid conditions.Type: GrantFiled: January 13, 2020Date of Patent: August 2, 2022Assignee: Lupin, Inc.Inventors: James Garegnani, Nicholas Hart, Richard Holl
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Publication number: 20220087978Abstract: Method of treating or preventing trichomoniasis or T. vaginalis infection in a subject in need thereof, the method involving administering to the subject a therapeutically effective amount of secnidazole or a pharmaceutically acceptable salt in a microgranule formulation, wherein the microgranule formulation comprises a plurality of microgranules. The subject can also have bacterial vaginosis, is HIV-positive, and/or is suffering with metronidazole-resistant trichomoniasis and/or tinidazole-resistant trichomoniasis. The subject can also be a sexual partner of a person with trichomoniasis. The microgranule formulation can also be administered with paromomycin, tinidazole, metronidazole, boric acid or a combination thereof. Pharmaceutical compositions and uses for treating or preventing trichomoniasis or T. vaginalis infection in a subject in need thereof are also contemplated herein.Type: ApplicationFiled: September 22, 2020Publication date: March 24, 2022Applicant: LUPIN INC.Inventors: Helen S. PENTIKIS, David PALLING, Carol J. BRAUN, Richard HOLL, Gregory KAUFMAN
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Publication number: 20210260038Abstract: Method of treating a sexually transmitted infection in a subject in need thereof involving administering to the subject a therapeutically effective amount of secnidazole in a microgranule formulation, wherein the microgranule formulation comprises a plurality of microgranules having a volume-weighted particle size distribution within a microgranule population, wherein the volume-weighted particle size distribution as measured from a representative sample of the microgranule population comprises (a) 10% of the microgranule population having a volume-weighted particle size about no less than 470 micrometers; (b) 50% of the microgranule population having a volume-weighted particle size between about no less than 640 micrometers and about no more than 810 micrometers; (c) 90% of the microgranule population having a volume-weighted particle size about no more than 1170 micrometers; or (d) a combination thereof, which can include some or all of (a) through (c) above.Type: ApplicationFiled: May 7, 2021Publication date: August 26, 2021Applicant: LUPIN INC.Inventors: Helen S. PENTIKIS, David PALLING, Carol J. BRAUN, Richard HOLL
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Publication number: 20210154223Abstract: The invention described herein provides new methods and compositions for the cyclical provision of a vitamin B12 compound in a dosing regimen wherein the total amount of vitamin B12 administered during any one treatment cycle does not exceed 35 mcg. More specifically, the invention described in this disclosure promotes the prevention or treatment of a vitamin B12 deficiency, supports the replenishment and or maintenance of healthy blood cell levels, or both, particularly in those experiencing a periodic physiological challenge which may compromise vitamin B12 status or result in an increased requirement for vitamin B12, such as the monthly blood loss experienced by a reproductively cycling human female.Type: ApplicationFiled: November 18, 2020Publication date: May 27, 2021Inventors: James A Garegnani, Richard Holl, Gregory Kaufman
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Patent number: 11000508Abstract: Method of treating trichomoniasis in a subject in need thereof involving administering to the subject a therapeutically effective amount of secnidazole in a microgranule formulation, wherein the microgranule formulation comprises a plurality of microgranules having a volume-weighted particle size distribution within a microgranule population, wherein the volume-weighted particle size distribution as measured from a representative sample of the microgranule population comprises (a) at least 10% of the microgranule population having a volume-weighted particle size about no less than 470 micrometers; or (b) 50% of the microgranule population having a volume-weighted particle size between about no less than 640 micrometers and about no more than 810 micrometers; or (c) 90% of the microgranule population having a volume-weighted particle size about no more than 1170 micrometers; or (d) a combination thereof, which can include some or all of (a) through (c) above.Type: GrantFiled: June 15, 2020Date of Patent: May 11, 2021Assignee: LUPIN INC.Inventors: Helen S. Pentikis, David Palling, Carol J. Braun, Richard Holl
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Patent number: 11000507Abstract: Method of treating bacterial vaginosis in a subject in need thereof involving administering to the subject a therapeutically effective amount of secnidazole in a microgranule formulation, wherein the microgranule formulation comprises a plurality of microgranules having a volume-weighted particle size distribution within a microgranule population, wherein the volume-weighted particle size distribution as measured from a representative sample of the microgranule population comprises (a) at least 10% of the microgranule population having a volume-weighted particle size about no less than 470 micrometers; or (b) 50% of the microgranule population having a volume-weighted particle size between about no less than 640 micrometers and about no more than 810 micrometers; or (c) 90% of the microgranule population having a volume-weighted particle size about no more than 1170 micrometers; or (d) a combination thereof, which can include some or all of (a) through (c) above.Type: GrantFiled: March 12, 2020Date of Patent: May 11, 2021Assignee: LUPIN INC.Inventors: Helen S. Pentikis, David Palling, Carol J. Braun, Richard Holl
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Publication number: 20210015755Abstract: A soft gelatin capsule composition for vaginal administration of secnidazole includes a therapeutically effective amount of secnidazole dispersed in a pharmaceutically acceptable carrier. The therapeutically effective amount of secnidazole is in a range of from about 1 mg to about 500 mg, or in a range of from about 1,000 mg to about 1,500 mg. The composition is used for treating diseases, including bacterial vaginosis or trichomoniasis.Type: ApplicationFiled: July 17, 2019Publication date: January 21, 2021Applicant: Lupin Inc.Inventors: Richard Holl, James Garegnani, Gregory Kaufman
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Publication number: 20200306228Abstract: Method of treating trichomoniasis in a subject in need thereof involving administering to the subject a therapeutically effective amount of secnidazole in a microgranule formulation, wherein the microgranule formulation comprises a plurality of microgranules having a volume-weighted particle size distribution within a microgranule population, wherein the volume-weighted particle size distribution as measured from a representative sample of the microgranule population comprises (a) 10% of the microgranule population having a volume-weighted particle size about no less than 470 micrometers; (b) 50% of the microgranule population having a volume-weighted particle size between about no less than 640 micrometers and about no more than 810 micrometers; (c) 90% of the microgranule population having a volume-weighted particle size about no more than 1170 micrometers; or (d) a combination thereof, which can include some or all of (a) through (c) above.Type: ApplicationFiled: June 15, 2020Publication date: October 1, 2020Applicant: LUPIN INC.Inventors: Helen S. PENTIKIS, David PALLING, Carol J. BRAUN, Richard HOLL
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Publication number: 20200268756Abstract: New deuterated analogs of elagolix are provided. The novel deuterated elagolix analogs differ from the only previously disclosed deuterated elagolix analogs in structure based on the exclusion of deuterium at certain sites in the compounds and the inclusion of deuterium at other sites. Also provided are new formulations for deuterated elagolix compounds and methods of using such compounds and formulations in the modification of mammalian physiology and especially in the treatment and prevention of a number of diseases and disorders, including endometriosis-associated pain and uterine fibroid conditions.Type: ApplicationFiled: January 13, 2020Publication date: August 27, 2020Inventors: James Garegnani, Nicholas Hart, Richard Holl
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Publication number: 20200206192Abstract: Method of treating bacterial vaginosis in a subject in need thereof involving administering to the subject a therapeutically effective amount of secnidazole in a microgranule formulation, wherein the microgranule formulation comprises a plurality of microgranules having a volume-weighted particle size distribution within a microgranule population, wherein the volume-weighted particle size distribution as measured from a representative sample of the microgranule population comprises (a) 10% of the microgranule population having a volume-weighted particle size about no less than 470 micrometers; (b) 50% of the microgranule population having a volume-weighted particle size between about no less than 640 micrometers and about no more than 810 micrometers; (c) 90% of the microgranule population having a volume-weighted particle size about no more than 1170 micrometers; or (d) a combination thereof, which can include some or all of (a) through (c) above.Type: ApplicationFiled: March 12, 2020Publication date: July 2, 2020Applicant: LUPIN INC.Inventors: Helen S. PENTIKIS, David PALLING, Carol J. BRAUN, Richard HOLL
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Patent number: 10682338Abstract: Method of treating bacterial vaginosis in a subject in need thereof involving administering to the subject a therapeutically effective amount of secnidazole in a microgranule formulation, wherein the microgranule formulation comprises a plurality of microgranules having a volume-weighted particle size distribution within a microgranule population, wherein the volume-weighted particle size distribution as measured from a representative sample of the microgranule population comprises (a) 10% of the microgranule population having a volume-weighted particle size about no less than 470 micrometers; (b) 50% of the microgranule population having a volume-weighted particle size between about no less than 640 micrometers and about no more than 810 micrometers; (c) 90% of the microgranule population having a volume-weighted particle size about no more than 1170 micrometers; or (d) a combination thereof, which can include some or all of (a) through (c) above.Type: GrantFiled: July 30, 2018Date of Patent: June 16, 2020Assignee: Lupin Inc.Inventors: Helen S. Pentikis, David Palling, Carol J. Braun, Richard Holl
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Publication number: 20200179274Abstract: The invention relates to a drug delivery system for contraception including a steroidal estrogenic compound, a steroidal progestogenic compound or a combination thereof for the purposes of contraception in a subject, and provides for an ultra-low dose delivery of a steroidal estrogenic compound. The invention also relates to a method of contraception using the drug delivery system and method of manufacturing the drug delivery system.Type: ApplicationFiled: November 26, 2019Publication date: June 11, 2020Applicant: Lupin Inc.Inventors: Vinita Gupta, Richard Holl, James Garegnani, Gregory Kaufman
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Publication number: 20180333391Abstract: Method of treating bacterial vaginosis in a subject in need thereof involving administering to the subject a therapeutically effective amount of secnidazole in a microgranule formulation, wherein the microgranule formulation comprises a plurality of microgranules having a volume-weighted particle size distribution within a microgranule population, wherein the volume-weighted particle size distribution as measured from a representative sample of the microgranule population comprises (a) 10% of the microgranule population having a volume-weighted particle size about no less than 470 micrometers; (b) 50% of the microgranule population having a volume-weighted particle size between about no less than 640 micrometers and about no more than 810 micrometers; (c) 90% of the microgranule population having a volume-weighted particle size about no more than 1170 micrometers; or (d) a combination thereof, which can include some or all of (a) through (c) above.Type: ApplicationFiled: July 30, 2018Publication date: November 22, 2018Applicant: SYMBIOMIX THERAPEUTICS, LLCInventors: Helen S. PENTIKIS, David PALLING, Carol J. BRAUN, Richard HOLL
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Patent number: 8889174Abstract: A coaxial implant has been developed using biodegradable polymeric materials. The coaxial implant has a core containing drug, surrounded by a semi-permeable membrane that controls the rate of release of material from the core. The core containing the drug and the polymer membrane(s) can be the same or different polymer. The core acts as a reservoir of drug, which partitions from the core polymer to form a saturated solution of drug at the polymer membrane.Type: GrantFiled: August 20, 2012Date of Patent: November 18, 2014Assignee: Durect CorporationInventors: John W. Gibson, Arthur J. Tipton, Richard Holl, Stacey Meador
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Patent number: D1021076Type: GrantFiled: July 2, 2021Date of Patent: April 2, 2024Inventors: Richard Holl, Antonio Belton