Abstract: Techniques, systems, and assemblies are presented relating to micro spacers positioned between optical substrates. In some embodiments, a stacked optical assembly comprises a first optical substrate having a first index of refraction greater than 1.4, a second optical substrate having a second index of refraction greater than 1.4 and disposed in a stacked position relative to the first optical substrate, and a plurality of micro spacers positioned between the first optical substrate and the second optical substrate. The plurality of micro spacers may maintain a gap having a gap height between the first optical substrate and the second optical substrate. The plurality of micro spacers may be fixedly attached to (a) the first optical substrate, (b) the second optical substrate, or (c) both the first optical substrate and the second optical substrate.

Abstract: The disclosure provides novel methods and dosage regimens for use in treating or preventing pain, wherein the binding molecule comprises an NGF antagonist domain and a TNF? antagonist domain, wherein the NGF antagonist domain is an anti-NGF antibody or an antigen-binding fragment thereof and wherein the TNF? antagonist domain comprises a soluble TNF? binding fragment of TNFR.

Abstract: Devices used to provide transseptal access are disclosed. The devices may comprise at least one cannula, a needle, and a handle. The cannula and the needle may be configured to be inserted through a dilator while not damaging a lumen wall of the dilator. The handle may be configured to lock the needle in a retracted position. The devices may be configured to telescopically advance the needle through an atrial septum.

Abstract: In some aspects, the disclosure is directed to methods and systems for real-time tracking or monitoring of client device access during sessions as well as across or between sessions, and aggregation of monitoring data. Monitored data may be used to generate predictive scores for identification of anomalous or non-anomalous behavior, or predict success or failure of an access session or access to a given content item or page. By utilizing real-time monitoring and analysis, administrators may take proactive or mitigation actions dynamically, without waiting for requests from users of client devices and without the delay of offline analysis of logs.

Abstract: Hub assemblies that include a first hub and a second hub can be used to selectively couple and uncouple medical device components to and from each other without rotating the first hub relative to the second hub. Some hub assemblies can include a dilator that includes a dilator hub and an introducer sheath that includes an introducer sheath hub.

Abstract: Syringe systems including barrels having lubricated portions and non-lubricated portions are provided. The non-lubricated portions may be configured to be loaded with injectable materials, such as embolic agents. The injectable materials may comprise polyvinyl alcohol. Also provided are methods of lubricating portions of barrels of syringe systems with lubricants including silicone or silicone-free lubricants.

Abstract: Coverings for syringe plunger tips, as well as syringes and syringe components including such coverings, are disclosed. A material of the covering may have at least one different material property than a material of the plunger tip. The coverings may provide a reduced coefficient of friction between the covering and a surface of the syringe relative to the coefficient of friction between the plunger tip and the syringe surface. The coverings may also isolate a substance loaded in the syringe from the plunger tip. Methods for manufacturing a syringe assembly including such coverings, as well as methods for isolating a substance in a syringe from a syringe component, are also disclosed.

Abstract: Devices used to provide transseptal access are disclosed. The devices may comprise at least one cannula, a needle, and a handle. The cannula and the needle may be configured to be inserted through a dilator while not damaging a lumen wall of the dilator. The handle may be configured to lock the needle in a retracted position. The devices may be configured to telescopically advance the needle through an atrial septum.

Abstract: A method for replacing an existing generator frame that supports a generator of a wind turbine includes removing the generator from atop the existing generator frame. The method also includes dismounting a control cabinet of the wind turbine from the existing generator frame. More specifically, the control cabinet is electrically connected to one or more wind turbine components via a plurality of cables. The method further includes relocating and securing the control cabinet to an uptower location within a nacelle of the wind turbine with the plurality of cables remaining electrically connected. As such, the method includes removing the existing generator frame from within the nacelle. Moreover, the method includes installing a new generator frame in place of the removed existing generator frame. Thus, the method also includes remounting the control cabinet to the new generator frame.

Abstract: A medical device, assembly, or kit may be used to hold a plurality of elongate medical instruments, such as guidewires, catheters, etc. A guidewire holder may include a reservoir for holding a liquid and one or more separators for segregating the guidewires from each other. In some instances, the guidewire holder can hold a coiled guidewire such that the guidewire is in contact with liquid held by the reservoir.

Abstract: The invention provides a potassium-competitive acid blocker (P-CAB) for use in the treatment, prevention and/or reduction of gastro-esophageal reflux disease (GERD) symptoms in patients who are partial responders to a proton pump inhibitor (PPI). The P-CAB may, for example, be selected from 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine (vonoprazan), revaprazan (YH1855), YH4808, RQ-4 and CS-526, or a salt thereof.

Abstract: A method for replacing an existing generator frame that supports a generator of a wind turbine includes removing the generator from atop the existing generator frame. The method also includes dismounting a control cabinet of the wind turbine from the existing generator frame. More specifically, the control cabinet is electrically connected to one or more wind turbine components via a plurality of cables. The method further includes relocating and securing the control cabinet to an uptower location within a nacelle of the wind turbine with the plurality of cables remaining electrically connected. As such, the method includes removing the existing generator frame from within the nacelle. Moreover, the method includes installing a new generator frame in place of the removed existing generator frame. Thus, the method also includes remounting the control cabinet to the new generator frame.

Abstract: The invention provides a potassium-competitive acid blocker (P-CAB) for use in the treatment, prevention and/or reduction of gastro-esophageal reflux disease (GERD) symptoms in patients who are partial responders to a proton pump inhibitor (PPI). The P-CAB may, for example, be selected from 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine (vonoprazan), revaprazan (YH1855), YH4808, RQ-4 and CS-526, or a salt thereof.

Abstract: Coverings for syringe plunger tips, as well as syringes and syringe components including such coverings, are disclosed. A material of the covering may have at least one different material property than a material of the plunger tip. The coverings may provide a reduced coefficient of friction between the covering and a surface of the syringe relative to the coefficient of friction between the plunger tip and the syringe surface. The coverings may also isolate a substance loaded in the syringe from the plunger tip. Methods for manufacturing a syringe assembly including such coverings, as well as methods for isolating a substance in a syringe from a syringe component, are also disclosed.

Abstract: Syringe systems including barrels having lubricated portions and non-lubricated portions are provided. The non-lubricated portions may be configured to be loaded with injectable materials, such as embolic agents. The injectable materials may comprise polyvinyl alcohol. Also provided are methods of lubricating portions of barrels of syringe systems with lubricants including silicone or silicone-free lubricants.

Abstract: A rolling ultrasonic scanner comprises a member having an inspection surface for rolling across the surface of an object under test. A plurality of ultrasonic transducers are disposed within the member in a formation such that they are each aimed at a common point that is coincident with the surface of the object.

Abstract: Hub assemblies that include a first hub and a second hub can be used to selectively couple and uncouple medical device components to and from each other without rotating the first hub relative to the second hub. Some hub assemblies can include a dilator that includes a dilator hub and an introducer sheath that includes an introducer sheath hub.

Abstract: A medical device, assembly, or kit may be used to hold a plurality of elongate medical instruments, such as guidewires, catheters, etc. A guidewire holder may include a reservoir for holding a liquid and one or more separators for segregating the guidewires from each other. In some instances, the guidewire holder can hold a coiled guidewire such that the guidewire is in contact with liquid held by the reservoir.

Abstract: Systems and methods for a robust underwater vehicle are described herein. A robust underwater vehicle may include a force-limiting coupler connecting an actuation system to an actuation fin. The force-limiting coupler may be configured to break away from the actuation system upon receiving a threshold force. The robust underwater vehicle may also comprise hull sections connected by a threaded turnbuckle. Carbon-fiber axial strength members may mate with the threaded turnbuckle to pull the hull sections together to a specified preload tension. The robust underwater vehicle may also include a blazed sonar array protected by a carbon fiber bow including a plurality of slits. The plurality of slits may provide significant protection to the sonar array while simultaneously allowing one or more transducers to transmit sonar signals in a two-dimensional plane.