Abstract: A composition and process are provided for predicting the responsiveness of an individual to therapy for a pathological condition is based on detecting nucleic acid allele sequences in an interleukin-10 regulatory region or cytotoxic t-lymphocyte antigen-4 promoter or exon region of the individual. The detected nucleic acid allele is then associated with the level of therapeutic responsiveness to a pathological condition based upon genotype. Comparison across multiple alleles and regions improves the predictive nature of the process.

Abstract: The present invention provides methods of correlating genetic variants in the beta-chemokine receptor 5 (CCR5) locus, more specifically CCR5 promoter alleles and genotypes, with HIV-1 transmission and/or disease progression in individuals and populations.

Abstract: Game apparatus including a planar gameboard having indicia simulating a plurality of separate and unrelated sporting event courses such as a track for a bicycle race and track events, a boat rowing course, a swimming pool, an obstacle course, a baseball diamond, and a weightlifting match area. Gamepieces are moved along spaces on selected ones of the courses from a start to a finish line in accordance with the throw of a pair of dice and scores are determined on other ones of the courses by throwing the dice and consulting a chart on the gameboard associated with these courses. The number of dice throws to complete a selected course are converted to a time factor to determine a winner for these events, who is awarded a predetermined number of points. The high scorer on the other ones of the courses is the winner and is awarded points. Lesser finishers are also awarded points. These points are tallied on a scorecard to determine the overall winner of the game.