Abstract: Antibodies that bind ICOS (Inducible T cell Co-Stimulator). Therapeutic use of anti-ICOS antibodies for modulating the ratio between regulatory T cells and effector T cells, to stimulate the immune system of patients, including use in treating cancers. Methods of producing anti-ICOS antibodies, including species cross-reactive antibodies, using transgenic knock-out mice.

Abstract: A compact displacement sensor comprises a light intensity pattern object, a micro-lens array and an imaging device including a light-intensity measuring surface. The micro-lens array is disposed between the light intensity pattern object and the imaging device such that each micro-lens focuses a corresponding sub-image making up a portion of the light-intensity pattern on the light-intensity measuring surface to create thereupon an image of the object comprising an array of focused sub-images. The displacement sensor can provide high resolution measurements of displacement of the light intensity pattern object from a reference position by registering subsequent images captured after a change in relative position between light intensity pattern object and the imaging device to a reference image based on pattern portions in the focused sub-images.

Abstract: The present invention provides methods for using reutericyclin or an analog thereof to reduce weight gain or induce weight loss in a mammal. Also provided herein are methods for using reutericyclin-producing Lactobacillus reuterii bacteria as a probiotic to reduce weight gain or to induce weight loss, particularly for subjects receiving an antibiotic or xenobiotic treatment.

Abstract: The present invention provides methods for using reutericyclin or an analog thereof to reduce weight gain or induce weight loss in a mammal. Also provided herein are methods for using reutericyclin-producing Lactobacillus reuterii bacteria as a probiotic to reduce weight gain or to induce weight loss, particularly for subjects receiving an antibiotic or xenobiotic treatment.

Abstract: The present invention provides methods for using reutericyclin or an analog thereof to reduce weight gain or induce weight loss in a mammal. Also provided herein are methods for using reutericyclin-producing Lactobacillus reuterii bacteria as a probiotic to reduce weight gain or to induce weight loss, particularly for subjects receiving an antibiotic or xenobiotic treatment.

Abstract: A method and system for acquiring dense 3D depth maps and scene flow using a plurality of image sensors, each image sensor associated with an optical flow processor, the optical flow fields being aligned to find dense image correspondences. The disparity and/or ratio of detected optical flows in corresponding pixels combined with the parameters of the two optical paths and the baseline between the image sensors is used to compute dense depth maps and scene flow.

Abstract: The present disclosure is directed at a snowpack measurement device that is configurable between a skiing configuration, in which it can be used as a ski pole, and a snowpack measurement configuration, in which it can be used as a probe to measure one or more characteristics of a snowpack. In some embodiments, the device can wirelessly transmit snowpack measurement results, for example, to a user's mobile device. The device can house sensitive electronics and sensors for the snowpack measurement tool within a ski pole handle of the device when not in use.

Abstract: A method and system for 3D surface mapping system using a plurality of image sensors, each image sensor associated with an optical flow processor, each image sensor sharing a substantially coaxial optical path from the scene to a beam splitter and having substantially non-coaxial optical paths between the beam splitter and the image sensor such that the optical magnification of each optical path varies differently with the distance between the system and the surface of interest. The ratio of detected optical flows combined with the parameters of the two optical paths and the baseline between the image sensors is used to compute the Z-distance from the optical center of the image sensors to the surface.

Abstract: A method and system for 3D surface mapping system using a plurality of image sensors, each image sensor associated with an optical flow processor, each image sensor sharing a substantially coaxial optical path from the scene to a beam splitter and having substantially non-coaxial optical paths between the beam splitter and the image sensor such that the optical magnification of each optical path varies differently with the distance between the system and the surface of interest. The ratio of detected optical flows combined with the parameters of the two optical paths and the baseline between the image sensors is used to compute the Z-distance from the optical center of the image sensors to the surface.

Abstract: A method and system for determining the location and attitude (roll, pitch, and yaw) of a moving object relative to an external reference frame by tracking unique two-dimensional patterns in the external reference frame from the moving object with displacement sensors. The displacement sensors lock onto the unique two-dimensional patterns by means of a steering mechanism which steers an optical path element capable of deviating the optical path using the displacement information from the relative movement of the two-dimensional patterns. The system is able to detect position and attitude to sub-millimeter accuracy without a physical connect between the moving object and the external reference frame and without a physical connection between the moving object and the external reference frame.

Abstract: A mounting and suspension system for mounting non-contact sliding measurement devices to the side of objects that slide on snow or ice like skis, snowboards, sleds, luges, and ice skates. A base component permanently attached to the sliding object allows a quick disconnect of the rest of the device. A linkage component permits the retraction of the measurement device relative to the sliding object in such a way that the measurement device remains aligned with the surface being measured while minimizing lateral displacement and fully retracted vertical height such that accurate measurement is obtained at any angle of sliding object relative to the surface of snow or ice. A bias device keeps the measurement device in firm contact with the surface without interfering with the use of the sliding object. A safety device prevents injury to user and damage to measurement device in case of impact with an external obstacle or fall.

Abstract: A method and system for determining the location and attitude (roll, pitch, and yaw) of a moving object relative to an external reference frame by tracking unique two-dimensional patterns in the external reference frame from the moving object with displacement sensors. The displacement sensors lock onto the unique two-dimensional patterns by means of a steering mechanism which steers an optical path element capable of deviating the optical path using the displacement information from the relative movement of the two-dimensional patterns. The system is able to detect position and attitude to sub-millimeter accuracy without a physical connect between the moving object and the external reference frame and without a physical connection between the moving object and the external reference frame.

Abstract: The invention concerns a system for the measurement of the speed of a ski containing a devices attached to the ski capable of taking successive images of the surface passing under the ski, some means of measuring displacement by comparing successive images, and some means of calculating the speed from the measured displacement.

Abstract: A suspension system for a measuring instrument maintains contact with an object to be imaged or measured under circumstances that include a high degree of vibration by providing damping in only one direction. The system includes a rotating shaft with a friction damper that engages the outer surface of the shaft, but relative rotation with respect to the shaft occurs only for rotational motion in one direction.

Abstract: A mounting and suspension system for mounting non-contact sliding measurement devices to the side of objects that slide on snow or ice like skis, snowboards, sleds, luges, and ice skates. A base component permanently attached to the sliding object allows a quick disconnect of the rest of the device. A linkage component permits the retraction of the measurement device relative to the sliding object in such a way that the measurement device remains aligned with the surface being measured while minimizing lateral displacement and fully retracted vertical height such that accurate measurement is obtained at any angle of sliding object relative to the surface of snow or ice. A bias device keeps the measurement device in firm contact with the surface without interfering with the use of the sliding object. A safety device prevents injury to user and damage to measurement device in case of impact with an external obstacle or fall.

Abstract: The present disclosure is directed to apparatus and methods for analyzing the motion of sporting equipment, such as a golf club, a baseball bat, a hockey stick, or a tennis racquet. The apparatus comprises an imaging system in communications with the sporting equipment to measure motion parameters. The imaging system may be located on the sporting equipment or, optionally, within the sporting equipment. The systems and methods described herein can be used to determine the impact location of the sporting equipment with another object, the momentum transferred, the velocity of the sporting equipment and/or the angular orientation of the sporting equipment during a motion.

Abstract: An improved wireless timing system shown in FIG. 1 comprising a means of transmitting wirelessly a signal (12) triggered by the reception of an electrical impulse from a timing event detector (11). The transmitter (12) being low power and thus short range to reduce cost, power consumption and interference with other timing systems. The individual or object being timed transports a portable timing unit (16), which could be in the form of a wrist watch, that is capable of receiving the wireless timing signal and calculating the passage of time between successive receptions of timing signals.

Abstract: A window for installation in a sandwich composite beam shown in FIG. 2B that contains window body (18), tabs (22), and a means of attaching the tabs to the composite sandwich beam. The means of attaching tabs (22) could be an interlocking mechanism such as dowel interlock feature (48) in FIG. 3A. The window body (18) protects the composite beam core from moisture. Structural webbing (24) allows the strength and flexibility of the window to be adjusted to match the beam it is being installed in. The structural window also provides a platform for an imaging system shown in FIG. 6 including illumination source (36), collimating lens (34), and imaging lens (38).

Abstract: The telecommunications network includes a mobile switching center coupled to a home location register database for accepting calls from a wireless handset, a Public Switched Telephone Network that carries calls between distant switching centers, and a local network for terminating calls. The system works while a wireless subscriber is outside their home calling area also known as “roaming”. The system includes a method for dynamically routing wireless inter-exchange (long distance) calls in a telecommunications network by sending transaction capabilities application part messages containing instructions regarding call handling. It includes a method for sending transaction capabilities application part messages containing call setup parameters between a mobile switching center and a service control platform and a method for billing the long distance calls on the wireless subscriber's monthly statement.

Abstract: The invention concerns a system for the measurement of the speed of a ski containing a devices attached to the ski capable of taking successive images of the surface passing under the ski, some means of measuring displacement by comparing successive images, and some means of calculating the speed from the measured displacement.