Patents by Inventor Richard A. Leese
Richard A. Leese has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8937040Abstract: Provided herein is an antibacterial compound of the following formula: or a pharmaceutically acceptable salt thereof. The antibacterial compound has antibacterial properties against a diverse range of gram negative bacteria and reduced toxicity compared to polymyxins such as polymyxin B. Also provided are antibacterial pharmaceutical compositions containing the antibacterial compound, as well as methods for preparing the antibacterial compound.Type: GrantFiled: December 21, 2012Date of Patent: January 20, 2015Assignee: BioSource Pharm, Inc.Inventor: Richard A. Leese
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Patent number: 8906866Abstract: Provided herein are novel compounds and novel protected compounds that can be derived from polymyxin, including, e.g., polymyxin A. The novel compounds have antibacterial properties against a diverse range of Gram negative bacteria and reduced toxicity compared to polymyxins such as polymyxin A. Also provided are antibacterial pharmaceutical compositions containing the novel compounds and novel protected compounds, as well as methods for preparing the antibacterial compounds and protected compounds.Type: GrantFiled: March 15, 2013Date of Patent: December 9, 2014Assignees: BioSource Pharm, Inc., Cubist Pharmaceuticals, Inc.Inventors: William V. Curran, Christopher M. Liu, Amy C. D. Bombardier, Richard A. Leese, You Seok Hwang, Blaise S. Lippa, Yanzhi Zhang
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Patent number: 8889826Abstract: Disclosed herein are novel peptides and protected peptides. These compounds can be derived from naturally occurring peptides, such as those selected from colistin, circulin A, polymyxin A, polymyxin B, polymyxin D, octapeptin B, octapeptin C, and [Ile7]polymyxin B1. Also disclosed are pharmaceutical compositions containing the new peptides, as well as methods for preparing the novel peptides and protected peptides.Type: GrantFiled: July 1, 2005Date of Patent: November 18, 2014Assignee: BioSource Pharm, Inc.Inventors: Richard A. Leese, Noreen Francis, William V. Curran, Donald B. Borders, Howard Jarolmen
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Patent number: 8415307Abstract: Provided herein are novel compounds and novel protected compounds that can be derived from polymyxin, including, e.g., polymyxin A. The novel compounds have antibacterial properties against a diverse range of Gram negative bacteria and reduced toxicity compared to polymyxins such as polymyxin A. Also provided are antibacterial pharmaceutical compositions containing the novel compounds and novel protected compounds, as well as methods for preparing the antibacterial compounds and protected compounds.Type: GrantFiled: June 23, 2011Date of Patent: April 9, 2013Assignees: BioSource Pharm, Inc., Cubist Pharmaceuticals, Inc.Inventors: William V. Curran, Christopher M. Liu, Amy C. D. Bombardier, Richard A. Leese, You Seok Hwang, Blaise S. Lippa, Yanzhi Zhang
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Patent number: 8343912Abstract: Provided herein is an antibacterial compound of the following formula: or a pharmaceutically acceptable salt thereof. The antibacterial compound has antibacterial properties against a diverse range of gram negative bacteria and reduced toxicity compared to polymyxins such as polymyxin B. Also provided are antibacterial pharmaceutical compositions containing the antibacterial compound, as well as methods for preparing the antibacterial compound.Type: GrantFiled: December 22, 2009Date of Patent: January 1, 2013Assignee: Biosource Pharm, Inc.Inventor: Richard A. Leese
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Patent number: 7868135Abstract: The present invention provides derivatives of lipopeptide antibiotics that display antimicrobial activity against microorganisms, methods and compounds for synthesizing such antimicrobial derivatives and analogues, and methods of using the compounds in a variety of contexts, including in the treatment and prevention of microbial infections.Type: GrantFiled: June 28, 2004Date of Patent: January 11, 2011Assignee: Biowest Therapeutics Inc.Inventors: Dale R. Cameron, Vincent A. Boyd, Richard A. Leese, William V. Curran, Donald B. Borders, Paulo W. M. Sgarbi, Shirley A. Wacowich-Sgarbi, Matthew Nodwell, Yuchen Chen, Qi Jia, Dominique Dugourd
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Publication number: 20100160215Abstract: Provided herein are novel compounds and novel protected compounds that can be derived from polymyxin, including, e.g., polymyxin B1 and [Il7] polymyxin B1. The novel compounds have antibacterial properties against a diverse range of gram negative bacteria and reduced toxicity compared to polymyxins such as polymyxin B. Also provided are antibacterial pharmaceutical compositions containing the novel compounds and novel protected compounds, as well as methods for preparing the antibacterial compounds and protected compounds.Type: ApplicationFiled: December 22, 2009Publication date: June 24, 2010Inventor: Richard A. Leese
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Publication number: 20080207874Abstract: Novel protected cyclopeptide intermediates are prepared from polymyxin B are used to synthesize new peptide antibiotics. Intermediates are readily derivatized and deprotected to provide new families of antibiotics, which have potent anti-bacterial activity against gram-negative bacteria; but also are useful and potent against gram-positive bacteria.Type: ApplicationFiled: July 1, 2005Publication date: August 28, 2008Applicant: BioSource Pharm, Inc.Inventors: Richard A. Leese, Noreen Francis, William V. Curran, Donald B. Borders, Howard Jarolmen
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Publication number: 20060004185Abstract: Novel protected cyclopeptide intermediates are prepared from polymyxin B are used to synthesize new peptide antibiotics. Intermediates are readily derivatized and deprotected to provide new families of antibiotics, which have potent anti-bacterial activity against gram-negative bacteria; but also are useful and potent against gram-positive bacteria.Type: ApplicationFiled: July 1, 2004Publication date: January 5, 2006Inventors: Richard Leese, Noreen Francis, William Curran, Donald Borders, Howard Jarolmen
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Publication number: 20050153876Abstract: The present invention provides derivatives of lipopeptide antibiotics that display antimicrobial activity against microorganisms, methods and compounds for synthesizing such antimicrobial derivatives and analogues, and methods of using the compounds in a variety of contexts, including in the treatment and prevention of microbial infections.Type: ApplicationFiled: June 28, 2004Publication date: July 14, 2005Applicant: Migenix Inc.Inventors: Dale Cameron, Vincent Boyd, Richard Leese, William Curran, Donald Borders, Paulo Sgarbi, Shirley Wacowich-Sgarbi, Mathew Nodwell, Yuchen Chen, Qi Jia, Dominique Dugourd
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Patent number: 6767718Abstract: Novel cyclodepsipeptide intermediates have been prepared from the A21978 complex and used to synthesize new lipodepsipeptide antibiotics. The three intermediates can be readily derivatized to give new families of antibiotics that have potent antibacterial activity against gram positive bacteria.Type: GrantFiled: May 10, 2002Date of Patent: July 27, 2004Assignee: BioSource Pharm, Inc.Inventors: Richard A. Leese, William V. Curran, Donald B. Borders
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Patent number: 6750199Abstract: The present invention provides antimicrobial sulfonamide derivatives of lipopeptide antibiotics, pharmaceutical compositions of antimicrobial sulfonamide derivatives, methods for making antimicrobial sulfonamide derivatives, methods for inhibiting microbial growth with antimicrobial sulfonamide derivatives and methods for treating or preventing microbial infections in a subject with antimicrobial sulfonamide derivatives. Antimicrobial sulfonamide derivatives are generally an amino core antibiotic that has been further modified with a lipophilic sulfonyl group.Type: GrantFiled: July 13, 2001Date of Patent: June 15, 2004Assignee: Micrologix Biotech Inc.Inventors: William V. Curran, Richard A. Leese, Howard Jarolmen, Donald B. Borders
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Patent number: 6737403Abstract: The present invention provides laspartomycin core peptides, laspartomycin core peptide derivatives, antimicrobial laspartomycin derivatives, methods for making laspartomycin core peptides, methods for making laspartomycin core peptide derivatives, methods for making antimicrobial laspartomycin derivatives, pharmaceutical compositions of antimicrobial laspartomycin derivatives, methods of inhibiting microbial growth and methods for treating and/or preventing microbial infections in a subject.Type: GrantFiled: July 13, 2001Date of Patent: May 18, 2004Assignee: Micrologix Biotech Inc.Inventors: Donald B Borders, William V Curran, Amedeo A Fantini, Noreen D Francis, Howard Jarolmen, Richard A Leese
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Publication number: 20030224475Abstract: Novel cyclodepsipeptide intermediates have been prepared from the A21978 complex and used to synthesize new lipodepsipeptide antibiotics. The three intermediates can be readily derivatized to give new families of antibiotics that have potent antibacterial activity against gram positive bacteria.Type: ApplicationFiled: May 10, 2002Publication date: December 4, 2003Inventors: Richard A. Leese, William V. Curran, Donald B. Borders
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Patent number: 6511962Abstract: The present invention provides a laspartomycin core peptide, a laspartomycin core peptide derivative, a antimicrobial laspartomycin derivative, a method for making laspartomycin core peptides, methods for making laspartomycin core peptide derivatives, methods for making antimicrobial laspartomycin derivatives, pharmaceutical compositions of antimicrobial laspartomycin derivatives, methods of inhibiting microbial growth and methods for treating and/or preventing microbial infections in a subject.Type: GrantFiled: January 12, 2001Date of Patent: January 28, 2003Assignee: Micrologix Biotech Inc.Inventors: Donald B Borders, William V Curran, Amedeo A Fantini, Noreen D Francis, Howard Jarolmen, Richard A Leese
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Publication number: 20020028771Abstract: The present invention provides antimicrobial sulfonamide derivatives of lipopeptide antibiotics, pharmaceutical compositions of antimicrobial sulfonamide derivatives, methods for making antimicrobial sulfonamide derivatives, methods for inhibiting microbial growth with antimicrobial sulfonamide derivatives and methods for treating or preventing microbial infections in a subject with antimicrobial sulfonamide derivatives. Antimicrobial sulfonamide derivatives are generally an amino core antibiotic that has been further modified with a lipophilic sulfonyl group.Type: ApplicationFiled: July 13, 2001Publication date: March 7, 2002Inventors: William V. Curran, Richard A. Leese, Howard Jarolmen, Donald B. Borders
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Patent number: 5675030Abstract: The invention provides a method for selectively extracting a compound of formula I: ##STR1## wherein: R is hydrogen or --NR.sub.3 R.sub.4 ; and when R=--NR.sub.3 R.sub.4, R.sub.3 and R.sub.4 may be the same or different and are selected from hydrogen and straight or branched (C.sub.1 -C.sub.4)alkyl; R.sub.1 and R.sub.2 may be the same or different and are selected from straight or branched (C.sub.1 -C.sub.6)alkyl; from an aqueous mixture containing a compound of Formula I, its C-4 epimer and its oxidative degradation by-products by adding methylene at a concentration of 2-4 ml of methylene chloride per gram of compound of Formula I and at a pH between pH 6.5-8.0; and obtaining an extract containing methylene chloride, a compound of Formula I, and its C-4 epimer, said epimer being present in an amount of less than 3% of the amount of the compound of Formula I.Type: GrantFiled: November 16, 1994Date of Patent: October 7, 1997Assignee: American Cyanamid CompanyInventors: Lalitha Krishnan, Richard A. Leese, Raghavan Krishnan
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Patent number: 4312835Abstract: A Peltier effect thermal control sample containment means for an automatic sample holding apparatus used in conjunction with a liquid chromatograph analysis. The apparatus provides for the cooling or heating of a plurality of liquid chromatography samples and the maintenance of said samples at specific temperatures for extended periods of time.Type: GrantFiled: April 21, 1980Date of Patent: January 26, 1982Assignee: American Cyanamid CompanyInventors: Bart J. Zoltan, Richard A. Leese