Patent number: 5698179
Abstract: An iodinated neuroprobe is provided for mapping monoamine reuptake sites. The iodinated neuroprobe is of the formula: ##STR1## wherein: R=aryl, substituted aryl, heterocyclic, CO(CH.sub.2).sub.n Y, (CH.sub.2).sub.n CHF.sub.2, and (CF.sub.2).sub.n Y, wherein:Y=Cl, Br, I, (CH.sub.2).sub.m, aryl, substituted aryl, heterocyclic CO.sub.2 H, CO.sub.2 R.sup.3, CO.sub.2 NR.sup.3 R.sup.4, OH, OR.sup.3, CH(OR.sup.3).sub.2, CR.sup.3 (OR.sup.4).sub.2, OC0R.sup.3, OSO.sub.2 R.sup.3, OCONR.sup.3 R.sup.4, OCOOR.sup.3, CONR.sup.3 R.sup.4, NR.sup.3 R.sup.4, NR.sup.3 COR.sup.4, NR.sup.3 CO.sub.2 R.sup.4, NR.sup.3 CONR.sup.4 R.sup.5, NCS, NCO;R.sup.3, R.sup.4 and R.sup.5 =alkyl, substituted alkyl, alkenyl, substituted alkenyl, aryl, substituted aryl, or heterocyclic;m=3-8; andn=1-6;R'=C.sub.w H.sub.2w+1 wherein w=0-6 and C includes an isotope of carbon; andX=an isotope of Cl, an isotope of Br, an isotope of F, an isotope of I, or Sn(R".sub.1 R".sub.2 R".sub.3), whereinR".sub.1 =a C.sub.p H.sub.
Type:
Grant
Filed:
June 6, 1995
Date of Patent:
December 16, 1997
Assignee:
Neuro Imaging Technologies, LLC
Inventors:
John L. Neumeyer, Richard A. Milius, Robert B. Innis