Patents by Inventor Richard A. Partyka

Richard A. Partyka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 6-Oxamorphinans
    Patent number: 4246413
    Abstract: Substituted 6-oxamorphinans and 6-oxaisomorphinans have been found to possess potent analgetic, narcotic antagonist, antitussive and/or ADH inhibitory activity. The compounds are prepared by total synthesis and are not derived from opium alkaloids.
    Type: Grant
    Filed: May 14, 1979
    Date of Patent: January 20, 1981
    Assignee: Bristol-Myers Company
    Inventors: Thomas A. Montzka, John D. Matiskella, Richard A. Partyka
  • 14-Hydroxy-6-oxamorphinans and 14-hydroxy-6-oxaisomorphinans
    Patent number: 4228285
    Abstract: 14-Hydroxy-6-oxamorphinans and 14-hydroxy-6-oxaisomorphinans optionally substituted in the 3-, 7- and 17-positions have been found to possess potent analgetic, narcotic antagonist, antitussive and/or ADH inhibitory activity. The compounds are prepared by total synthesis and are not derived from opium alkaloids.
    Type: Grant
    Filed: February 28, 1979
    Date of Patent: October 14, 1980
    Assignee: Bristol-Myers Company
    Inventors: Thomas A. Montzka, John D. Matiskella, Richard A. Partyka
  • 1,2,3-Thiadiazole process
    Patent number: 4171363
    Abstract: A series of novel 4-amino-2-(thiadiazole-carbonyl piperazinyl)-6,7-dimethoxyquinazolines is disclosed having antihypertensive properties. The thiadiazole substituent may be optionally substituted with alkyl or lower alkoxy carbonylamino groups. A representative embodiment of the invention is 4-amino-6,7-dimethoxy-2-[4-(5-ethoxy-carbonylamino-1,2,3-thiadiazole-4-car bonyl)-piperazin-1-yl]-quinazoline.
    Type: Grant
    Filed: May 17, 1978
    Date of Patent: October 16, 1979
    Assignee: Bristol-Myers Company
    Inventors: Ronnie R. Crenshaw, Richard A. Partyka
  • 6-Oxamorphinans
    Patent number: 4154932
    Abstract: N-substituted 6-oxamorphinans have been found to possess potent analgetic, narcotic antagonist, antitussive, and ADH inhibitory activity. A particularly preferred compound is (-)-17-cyclopropylmethyl-3-hydroxy-6-oxamorphinan. The compounds are prepared by total synthesis and are not derived from opium alkaloids.
    Type: Grant
    Filed: September 8, 1977
    Date of Patent: May 15, 1979
    Assignee: Bristol-Myers Company
    Inventors: Thomas A. Montzka, John D. Matiskella, Richard A. Partyka
  • Alkyl 5,6-dichloro-3,4-dihydro-2(1H)-iminoquinazoline-3-acetate hydrohalides
    Patent number: 4146718
    Abstract: The known blood platelet antiaggregative agent 6,7-dichloro-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-one is prepared in high yield via an improved process involving a novel intermediate of the Formula ##STR1## in which R.sup.1 is (lower)alkyl and X is bromo, chloro or iodo.
    Type: Grant
    Filed: April 10, 1978
    Date of Patent: March 27, 1979
    Assignee: Bristol-Myers Company
    Inventors: Thomas A. Jenks, Warren N. Beverung, Jr., Richard A. Partyka
  • Cyanocarboxamidines and quinazoline process
    Patent number: 4138561
    Abstract: Novel cyanocarboxamidines are disclosed. The new cyanocarboxamidines are particularly valuable as intermediates in the preparation of antihypertensive 4-amino-2-(4-substituted-piperazin-1-yl)-quinazolines.
    Type: Grant
    Filed: September 30, 1977
    Date of Patent: February 6, 1979
    Assignee: Bristol-Myers Company
    Inventors: Ronnie R. Crenshaw, George M. Luke, Richard A. Partyka
  • Pyrimido[2,1-a]isoquinoline derivatives having antiallergy activity
    Patent number: 4127720
    Abstract: A series of novel pyrimido[2,1-a]isoquinoline derivatives is provided for use as inhibitors of allergic reactions. The compounds exhibit antiallergy activity by both oral and parenteral routes of administration.
    Type: Grant
    Filed: September 21, 1977
    Date of Patent: November 28, 1978
    Assignee: Bristol-Myers Company
    Inventors: Peter F. Juby, Thomas W. Hudyma, Richard A. Partyka
  • 2-Amino-1-(2,5-dimethoxyphenyl)-butanes
    Patent number: 4105695
    Abstract: Compounds of the formula ##STR1## wherein R.sup.1 is Cl, Br, (lower)alkylthio or ##STR2## in which R.sup.3 is H or (lower)alkyl including the racemic mixtures and the dextrorotatory and levorotatory isomers, and the pharmaceutically acceptable non-toxic salts thereof have been found to enhance the learning capacity of mammals, including man, and to improve the mental alertness and attitudes of geriatrics without producing the undesirable stimulant side effects associated with the use of amphetamines.
    Type: Grant
    Filed: May 11, 1977
    Date of Patent: August 8, 1978
    Assignee: Bristol-Myers Company
    Inventors: Richard A. Partyka, Robert T. Standridge, Henry G. Howell, Alexander T. Shulgin
  • 1,2,3-Thiadiazole amides
    Patent number: 4101548
    Abstract: A series of novel 4-amino-2-(thiadiazole-carbonyl piperazinyl)-6,7-dimethoxyquinazolines is disclosed having antihypertensive properties. The thiadiazole substituent may be optionally substituted with alkyl or lower alkoxy carbonylamino groups. A representative embodiment of the invention is 4-amino-6,7-dimethoxy-2-[4-(5-ethoxy-carbonylamino-1,2,3-thiadiazole-4-car bonyl)-piperazin-1-yl]-quinazoline.
    Type: Grant
    Filed: February 22, 1977
    Date of Patent: July 18, 1978
    Assignee: Bristol-Myers Company
    Inventors: Ronnie R. Crenshaw, Richard A. Partyka