Abstract: The present invention provides novel imidazo[4,5-c]quinoline and imidazo[4,5-c][1,5]naphthyridine derivatives of Formula (I), and the pharmaceutically acceptable salts thereof wherein R1, R1a, R1b, R2, R4, R5, R6, X and Z are as defined in the specification. The invention is also directed to pharmaceutical compositions comprising the compounds of Formula (I) and to use of the compounds in the treatment of diseases associated with LRRK2, such as neurodegenerative diseases including Parkinson's disease or Alzheimer's disease, cancer, Crohn's disease or leprosy.

Abstract: The present invention provides novel imidazo[4,5-c]quinoline and imidazo[4,5-c][1,5]naphthyridine derivatives of Formula (I), and the pharmaceutically acceptable salts thereof wherein R1, R1a, R1b, R2, R4, R5, R6, X and Z are as defined in the specification. The invention is also directed to pharmaceutical compositions comprising the compounds of Formula (I) and to use of the compounds in the treatment of diseases associated with LRRK2, such as neurodegenerative diseases including Parkinson's disease or Alzheimer's disease, cancer, Crohn's disease or leprosy.

Abstract: An isotope production target may include an outer diameter wall and an inner diameter wall. An isotope source may be located between the inner diameter wall and the outer diameter wall, and the isotope source may comprise fissile material interspersed with one or more voided regions. A central region may be located within the inner diameter wall, and the central region may be configured to house a neutron thermalization volume.

Abstract: An isotope production target may include an outer diameter wall and an inner diameter wall. An isotope source may be located between the inner diameter wall and the outer diameter wall, and the isotope source may comprise fissile material interspersed with one or more voided regions. A central region may be located within the inner diameter wall, and the central region may be configured to house a neutron thermalization volume.

Abstract: A method, system, and computer program product for performing oilfield surveillance operations. The oilfield has a subterranean formation with geological structures and reservoirs therein. The oilfield is divided into a plurality of patterns, with each pattern comprising a plurality of wells. Historical production/injection data is obtained for the plurality of wells. Two independent statistical treatments are performed to achieve a common objective of production optimization. In the first process, wells and/or patterns are characterized based on Heterogeneity Index results and personalities with the ultimate goal of field production optimization. In the second process, the history of the flood is divided into even time increments. At least two domains for each of the plurality of wells are determined. Each of the at least two domains are centered around each of the plurality wells. A first domain of the at least two domains has a first orientation.

Abstract: A wheel assembly for a vehicle such as a tractor is disclosed. The assembly comprises a wheel rim (10) for supporting a tire, a nave plate (11) mounted to the rim, and a drive plate (21) mounted to an axle flange (26). A torque ring (18) has first key ways (16, 17) for cooperating with first keys (14, 15) on nave plate (11), and second key ways (19, 20) for cooperating with second keys (22, 23) on drive plate (21). In this way, torque and radial and axial forces are transferred between the drive plate (21) and nave plate (11), but radial or axial forces, tending to remove the assembly from the axle, and exceeding respective predetermined levels, are prevented from being transferred from the nave plate (11) to the axle.

Abstract: A method, system, and computer program product for performing oilfield surveillance operations. The oilfield has a subterranean formation with geological structures and reservoirs therein. The oilfield is divided into a plurality of patterns, with each pattern comprising a plurality of wells. Historical production/injection data is obtained for the plurality of wells. Two independent statistical treatments are performed to achieve a common objective of production optimization. In the first process, wells and/or patterns are characterized based on Heterogeneity Index results and personalities with the ultimate goal of field production optimization. In the second process, the history of the flood is divided into even time increments. At least two domains for each of the plurality of wells are determined. Each of the at least two domains are centered around each of the plurality wells. A first domain of the at least two domains has a first orientation.

Abstract: A compressor control module for use with a pressurization system having a strain gauge transducer and a compressor. The compressor control module includes variable voltage references associated with low and high pressure limits, comparator circuits configured to compare the voltage from the strain gauge pressure transducer to the variable voltage references, a control logic circuit configured to logically combine signals from the comparator circuits, and a relay circuit configured to apply power to the compressor.

Abstract: A compressor control module for use with a pressurization system having a strain gauge transducer and a compressor. The compressor control module includes variable voltage references associated with low and high pressure limits, comparator circuits configured to compare the voltage from the strain gauge pressure transducer to the variable voltage references, a control logic circuit configured to logically combine signals from the comparator circuits, and a relay circuit configured to apply power to the compressor.

Abstract: The present invention provides laspartomycin core peptides, laspartomycin core peptide derivatives, antimicrobial laspartomycin derivatives, methods for making laspartomycin core peptides, methods for making laspartomycin core peptide derivatives, methods for making antimicrobial laspartomycin derivatives, pharmaceutical compositions of antimicrobial laspartomycin derivatives, methods of inhibiting microbial growth and methods for treating and/or preventing microbial infections in a subject.